[1]杨艳,梁薇,苟小军.过敏性鼻炎肺虚感寒证和肾阳亏虚证患者血清游离脂肪酸谱变化研究[J].西部中医药,2020,33(06):1-6.[doi:10.12174/j.issn.1004-6852.2020.06.01]
　YANG Yan,LIANG Wei,GOU Xiaojun.Research on Serum Free Fatty Acid Spectrum in Allergic Rhinitis Patients of Lung Deficiency and Cold Pattern and Kidney-yang Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2020,33(06):1-6.[doi:10.12174/j.issn.1004-6852.2020.06.01]
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过敏性鼻炎肺虚感寒证和肾阳亏虚证患者血清游离脂肪酸谱变化研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年06期
页码:
1-6
栏目:
出版日期:
2020-06-15

文章信息/Info

Title:
Research on Serum Free Fatty Acid Spectrum in Allergic Rhinitis Patients of Lung Deficiency and Cold Pattern and Kidney-yang Deficiency Pattern
文章编号:
1004-6852(2020)06-0001-06
作者:
杨艳，梁薇，苟小军
1 上海中医药大学附属曙光医院宝山分院，上海 201999； 2 上海市宝山区中西医结合医院
Author(s):
YANG Yan1, LIANG Wei1, GOU Xiaojun2△
1 Baoshan Branch of Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 201999, China; 2 Baoshan District Hospital of Integrative Medicine of Shanghai
关键词:
过敏性鼻炎; 肺虚感寒证; 肾阳亏虚证; 游离脂肪酸
Keywords:
AR;  lung deficiency and cold pattern;  kidney-yang deficiency pattern;  FFA
分类号:
R765.21
DOI:
10.12174/j.issn.1004-6852.2020.06.01
文献标志码:
A
摘要:
目的：基于代谢组学方法，分析过敏性鼻炎(allergic rhinits，AR)肺虚感寒证和肾阳亏虚证患者血清游离脂肪酸(FFA)谱的变化，探讨脂肪酸与中医证候的关系，为两种中医证型的科学辨证提供依据。方法：采用GC/MS技术检测过敏性鼻炎肺虚感寒证和肾阳亏虚证患者血清游离脂肪酸，利用SIMCA-P软件进行主成分分析(principal component analysis，PCA)及偏最小二乘法判别(PLSA-DA)分析，研究血清游离脂肪酸在两组间的差异。结果：AR肺虚感寒证、肾阳亏虚证患者游离脂肪酸(FFA)谱分离趋势良好。AR肺虚感寒证和肾阳亏虚证患者筛选得到了花生酸(C20:0)、二十一酸(C21:0)、榆树酸(C22:0)3个差异有统计学意义的血清游离脂肪酸。并对3个显著差异的脂肪酸进行了ROC曲线绘制，计算ROC曲线下的面积，得出C20:0曲线下的面积为O.778，C21:0曲线下的面积为O.764，C22:0曲线下的面积为O.792.结论：血清游离脂肪酸(FFA)谱的变化与过敏性鼻炎证候有一定的关系，花生酸(C20:0)、二十一酸(C21:0)、榆树酸(C22:0)可用于区分过敏性鼻炎肺虚感寒证和肾阳亏虚证患者潜在生物标志物。
Abstract:
Objective: To analyze the changes of serum free fatty acid (FFA) spectrum in allergic rhinits (AR) of lung deficiency and cold pattern and kidney-yang deficiency pattern based on metabolomics, and explore the relationship between fatty acid and TCM syndrome in order to provide the reference for scientific syndrome differentiation for two patterns. Methods: GC/MS technology was used to detect FFA of AR patients of lung deficiency and cold pattern and kidney-yang deficiency pattern, SIMCA-P software was utilized to perform PCA and PLSA-DA, and study the difference of FFA among different groups. Results: FFA spectrum in AR patients of lung deficiency and cold pattern and kidney-yang deficiency pattern demonstrated good separation trends. After screening, three kinds of FFAs including arachidic acid (C20:0), heneicosoic acid (C21:0) and behenic acid (C22:0) which were significantly different have been obtained. ROC curves of three different FFAs haven been drawn, the area under ROC cure was calculated, the area under C20:0 curve was 0.778, under C21:0 curve 0.764 and under C22:0 curve 0.792. Conclusion: The changes of FFA spectrum are related to the patterns of AR certainly, arachidic acid (C20:0), heneicosoic acid (C21:0) and behenic acid (C22:0) could be used as the potential biomarkers for differentiating the patients of lung deficiency and cold pattern and kidney-yang deficiency pattern.

相似文献/References:

[1]王兰娣,潘文,黄芸.鼻康胶囊治疗过敏性鼻炎117例临床观察*[J].西部中医药,2012,25(11):70.
　WANG Lan-di,PAN Wen,HUANG Yun.Clinical Observation on BiKang Capsules in Treating 117 Cases of Allergic Rhinitis[J].Western Journal of Traditional Chinese Medicine,2012,25(06):70.
[2]田永萍,赵耀东,毕爱平,等.温通针法治疗肺虚感寒型过敏性鼻炎疗效观察[J].西部中医药,2012,25(05):82.
　TIAN Yong-ping,ZHAO Yao-dong,BI Ai-ping,et al.Observation on Effects of ″Warming-Promotion Acupuncture″ in Treating Allergic Rhinitis of Pulmonary Deficiency & Invasion of Cold type[J].Western Journal of Traditional Chinese Medicine,2012,25(06):82.

备注/Memo

备注/Memo:
收稿日期：2019-08-02*基金项目：宝山区卫生青年人才培养计划(bswsyq-2017-A8)；宝山区科技创新专项基金项目(18-E-13)。作者简介：杨艳(1985—)，女，硕士学位，主治医师。研究方向：临床常见病与多发病的诊疗研究。△通讯作者：苟小军(1975—)，男，博士学位，副主任药师。研究方向：临床药学及其体内代谢研究。
更新日期/Last Update: 2020-06-15