[1]王准.通脉舒络汤治疗老年冠心病的临床观察[J].西部中医药,2020,33(06):81-84.[doi:10.12174/j.issn.1004-6852.2020.06.21]
　WANG Zhun.Observation on Clinical Effects of Tongmai Shuluo Tang in Treating Coronary Atherosclerotic Heart Disease in the Elderly[J].Western Journal of Traditional Chinese Medicine,2020,33(06):81-84.[doi:10.12174/j.issn.1004-6852.2020.06.21]
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通脉舒络汤治疗老年冠心病的临床观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年06期
页码:
81-84
栏目:
出版日期:
2020-06-15

文章信息/Info

Title:
Observation on Clinical Effects of Tongmai Shuluo Tang in Treating Coronary Atherosclerotic Heart Disease in the Elderly
文章编号:
1004-6852(2020)06-0081-04
作者:
王准
应城市人民医院药事管理科，湖北 应城 432400
Author(s):
WANG Zhun
Pharmacy Administration Department, Yingcheng City People′s Hospital, Yingcheng 432400, China
关键词:
冠心病; 动脉粥样硬化; 通脉舒络汤; 颈动脉内-中膜厚度; 机制
Keywords:
coronary heart disease;  atherosclerosis;  Tongmai Shuluo Tang;  carotid intima-media thickness; the mechanism
分类号:
R541.4
DOI:
10.12174/j.issn.1004-6852.2020.06.21
文献标志码:
B
摘要:
目的：探讨通脉舒络汤治疗气虚血瘀兼夹痰瘀证老年冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart，CHD)的临床疗效及作用机制。方法：将88例患者随机分为对照组和观察组，每组44例。对照组给予常规治疗，观察组在对照组基础上给予通脉舒络汤治疗，两组均以治疗4周为1个疗程，治疗2个疗程后评估临床疗效，测定一氧化氮(nitric oxide，NO)、血浆内皮素1(endothelin-1，ET-1)、丙二醛(malonaldehyde,MDA)、过氧化物歧化酶(superoxide dismutase，SOD)，颈动脉超声检测颈动脉内-中膜厚度(intima-media thickness，IMT)及斑块面积。结果：总有效率观察组为86.36%（38/44），对照组为68.18%（30/44），两组比较差异有统计学意义(P＜0.05)。NO、ET-1、MDA、SOD、IMT及斑块面积治疗前后两组组内比较，差异有统计学意义(P＜0.05)。药物不良反应发生率观察组为11.36%（5/44），对照组为9.09%（4/44），两组比较差异无统计学意义(P＞0.05)。结论：通脉舒络汤治疗气虚血瘀兼夹痰瘀证老年CHD，可减小IMT和斑块面积，可能与减轻氧化应激损伤、改善内皮功能障碍有关。
Abstract:
Objective: To explore clinical effects of Tongmai Shuluo Tang in treating the elderly with CHD of Qi-deficiency blood-stasis phlegm-stagnation pattern and study its mechanism. Methods: All 88 patients were randomized into the control group and the observation group, 44 cases each group. The control group accepted conventional therapy, and the observation group Tongmai Shuluo Tang, four weeks were one course, after treating for two courses, to assess clinical effects, detect NO, ET-1, MDA and SOD, to measure IMT and plaque area using carotid ultrasound. Results: Total effective rate of the observation group was 86.36% (38/44), higher than 68.18% (30/44) of the control group, and the difference had statistical meaning between both groups (P＜0.05). The difference was statistically significant in NO, ET-1, MDA, SOD, IMT and plaque area before and after treating between both groups (P＜0.05). The incidence of adverse drug reaction of the observation group was 11.36% (5/44), higher than 9.09% (4/44) of the control group, and the difference had no statistical meaning between both groups (P＞0.05). Conclusion: Tongmai Shuluo Tang in treating the elderly with CHD of Qi-deficiency blood-stasis phlegm-stagnation pattern could reduce IMT plaquearea, and it might be related to oxidative stress injury reduction and improving endothelial dysfunction.

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备注/Memo

备注/Memo:
收稿日期：2019-07-08*基金项目：武汉市科技计划项目［2(10951999575)］。作者简介：王准(1980—)，男，主管药师。研究方向：药学。
更新日期/Last Update: 2020-06-15