[1]邢秀玲,赵海鹰,杜美容,等.化痰逐瘀降脂汤治疗高脂血症临床疗效观察[J].西部中医药,2020,33(08):79-82.[doi:10.12174/j.issn.1004-6852.2020.08.20]
 XING Xiuling,ZHAO Haiying,DU Meirong,et al.Clinical Observation on Huatan Zhuyu Jiangzhi Tang in the Treatment of Hyperlipidemia[J].Western Journal of Traditional Chinese Medicine,2020,33(08):79-82.[doi:10.12174/j.issn.1004-6852.2020.08.20]
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化痰逐瘀降脂汤治疗高脂血症临床疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
33
期数:
2020年08期
页码:
79-82
栏目:
报道·临证经验
出版日期:
2020-08-15

文章信息/Info

Title:
Clinical Observation on Huatan Zhuyu Jiangzhi Tang in the Treatment of Hyperlipidemia
文章编号:
1004-6852(2020)08-0079-04
作者:
邢秀玲1赵海鹰2杜美容1孙映雪1王巍1刘伟然1王明星1林大勇3△白剑3
1 唐山市妇幼保健院,河北 唐山 063000; 2 中国人民解放军联勤保障部队第九八二医院;3 辽宁中医药大学
Author(s):
XING Xiuling1 ZHAO Haiying2 DU Meirong1 SUN Yingxue1 WANG Wei1LIU Weiran1 WANG Mingxing1 LIN Dayong3△ BAI Jian3
1 Tangshan City Maternal and Child Healthcare Hospital, Tangshan 063000, China;2 China People′s Liberation Army No. 982 Hospital; 3 Liaoning University of Traditional Chinese Medicine
关键词:
高脂血症化痰逐瘀降脂汤临床疗效不良反应
Keywords:
hyperlipidemia Huatan Zhuyu Jiangzhi Tang clinical effects adverse reaction
分类号:
R714.252
DOI:
10.12174/j.issn.1004-6852.2020.08.20
文献标志码:
B
摘要:
目的:观察化痰逐瘀降脂汤治疗高脂血症的临床疗效。方法:将128例高脂血症患者随机分为两组,每组64例。两组均口服阿托伐他汀钙片,每次10 mg,每日1次,晚餐前口服。观察组同时服用化痰逐瘀降脂汤,每日1剂,水煎分服。两组均连续服用40天。观察两组临床疗效、不良反应、血脂指标水平及生活质量评分。结果:总有率为观察组为95.4%(61/64),对照组为81.3%(52/64),两组比较差异有统计学意义(P<0.05)。肝功能异常、横纹肌溶解、胃肠道反应及周围神经感觉障碍等不良反应发生率观察组低于对照组,差异有统计学意义(P<0.05)。治疗前,血脂水平两组比较,差异无统计学意义(P>0.05);治疗后,总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)两组均下降,且观察组降低更明显,治疗前后同组内及治疗后组间比较,差异均有统计学意义(P<0.05);治疗后,高密度脂蛋白胆固醇(high density lipoprotein cholesterol,HDL-C)两组均上升,且观察组上升更明显,治疗前后同组内及治疗后组间比较,差异均有统计学意义(P<0.05)。治疗前,两组社会功能、躯体功能、角色功能、认知功能评分比较,差异无统计学意义(P>0.05);治疗后上述评分两组均上升,且观察组上升更明显,治疗前后同组内及治疗后组间比较,差异均有统计学意义(P<0.05)。结论:应用化痰逐瘀降脂汤治疗高脂血症患者,具有良好的临床治疗效果,不仅可以改善患者的血脂水平,提高患者的生活质量,还可降低不良反应的发生率。
Abstract:
Objective: To observe clinical effects of Huatan Zhuyu Jiangzhi Tang in the treatment of hyperlipidemia. Methods: All 128 patients were randomized into two groups, 64 cases each group. Both groups took atorvastatin calcium tablets, 10 mg each time, once each day, taking before the supper. The observation group took Huatan Zhuyu Jiangzhi Tang simultaneously, one dose each day, water decocted and taking twice. Both groups took the medicine for 40 days consecutively. To observe clinical effects, adverse reaction, the levels of blood lipid and the scores of quality of life in both groups. Results: Total effective rate of the observation group was 95.4% (61/64), higher than 81.3%(52/64) of the control group, and the difference showed statistical meaning (P<0.05). The observation group was lower than the control group in the incidence of adverse reactions including abnormal liver function, rhabdomyolysis, gastrointestinal reactions, sensory disturbance of peripheral nerves, and the difference showed statistical meaning (P<0.05). Before treating, the difference had no statistical meaning in the levels of blood lipid between both groups (P>0.05); after treating, the levels of TC, TG and LDL-C of both groups lowered, and the decrease of the observation group was more notable, the difference showed statistical meaning within one group before and after treating, between both groups after treating (P<0.05); after treating, the levels of HDL-C rose in both groups, and the rise of the observation group was more remarkable, the difference had statistical meaning within one group before and after treating, between both groups after treating (P<0.05). Before treating, the difference showed no statistical meaning in social function, somatic function, role function, cognitive function between both groups (P>0.05); after treating, the above scores in both groups increased, and the increase of the observation group was more notable, and the difference had statistical meaning within one group before and after treating, between both groups after treating (P<0.05). Conclusion: Huatan Zhuyu Jiangzhi Tang in treating the patients with hyperlipidemia could obtain notable clinical effects, it could not only improve the levels of blood lipid, lift quality of life, but also reduce the incidence of adverse reaction.

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备注/Memo

备注/Memo:
收稿日期:2019-09-23*基金项目:辽宁省自然基金项目(201602506)。作者简介:邢秀玲(1980—),女,硕士学位,主治医师。研究方向:中医内科疾病的诊治。△通讯作者:林大勇(1979—),男,硕士学位。研究方向:伤寒理论。
更新日期/Last Update: 2020-08-15