[1]韩胜男,李喜香,闫治攀,等.原位凝胶剂的研究概况[J].西部中医药,2021,34(01):153-157.[doi:10.12174/j.issn.2096-9600.2021.01.40]
　HAN Shengnan,LI Xixiang,YAN Zhipan,et al.Research Overview of In-situ Gel[J].Western Journal of Traditional Chinese Medicine,2021,34(01):153-157.[doi:10.12174/j.issn.2096-9600.2021.01.40]
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原位凝胶剂的研究概况
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年01期
页码:
153-157
栏目:
研究进展
出版日期:
2021-01-15

文章信息/Info

Title:
Research Overview of In-situ Gel
作者:
韩胜男1, 李喜香2, 闫治攀2, 张志瑞2
1.甘肃中医药大学药学院，甘肃 兰州 730000
2.甘肃省中医院
Author(s):
HAN Shengnan1, LI Xixiang2, YAN Zhipan2, ZHANG Zhirui2
1.School of Pharmacy, Gansu University of Chinese Medicine, Lanzhou 730000, China
2.Gansu Provincial Hospital of Traditional Chinese Medicine
关键词:
原位凝胶; 制备工艺; 质量标准; 综述
Keywords:
in-situ gel; preparation technology; quality standard; review
分类号:
R944
DOI:
10.12174/j.issn.2096-9600.2021.01.40
摘要:
从不同类型原位凝胶的制备及质量标准进行概述，指出原位凝胶是一种具有给药方便、靶向性强、良好的药物缓控释性能等优点的新型给药方式，但基质的刺激性和毒性还未十分明确，其制备方法及质量控制缺乏严格、统一的标准，制备工艺多样化，质量不可控，所以国内外应加大研究力度，尽快达成原位凝胶质量标准共识，以期更多的原位凝胶剂能够成功研发上市并让广大患者受益。
Abstract:
In-situ gel is a new drug delivery method with the advantages of convenient delivery, strong targeting, good sustained and controlled drug release through surveying the preparations and quality standard of different types of in-situ gels. However, the irritation and toxicity of matrix were not clear, its preparation method and quality control lacked strict and unified standards, the preparation technology was diverse, the quality was uncontrollable, therefore, more efforts should be made at home and abroad to reach a consensus on the quality standard of in-situ gel as soon as possible, in the hope of making more successful researches, development of the product and benefiting from most of patients.

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备注/Memo

备注/Memo:
韩胜男（1994—），女，在读硕士研究生。研究方向：中药制药工艺研究。
更新日期/Last Update: 2021-01-15