[1]张冬梅,张雅明,夏泽华.清肠愈疡汤口服及中药灌肠对溃疡性结肠炎患者血清I-FABP、sRAGE和p-ANCA水平的影响[J].西部中医药,2021,34(03):14-18.[doi:10.12174/j.issn.2096-9600.2021.03.04]
　ZHANG Dongmei,ZHANG Yaming,XIA Zehua.Effects of Oral Administration of Qingchang Yuyang Decoction and Herbal Enema on the Levels of Serum I-FABP, sRAGE and p-ANCA in UC Patients[J].Western Journal of Traditional Chinese Medicine,2021,34(03):14-18.[doi:10.12174/j.issn.2096-9600.2021.03.04]
点击复制

清肠愈疡汤口服及中药灌肠对溃疡性结肠炎患者血清I-FABP、sRAGE和p-ANCA水平的影响
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年03期
页码:
14-18
栏目:
临床论著
出版日期:
2021-03-15

文章信息/Info

Title:
Effects of Oral Administration of Qingchang Yuyang Decoction and Herbal Enema on the Levels of Serum I-FABP, sRAGE and p-ANCA in UC Patients
作者:
张冬梅, 张雅明, 夏泽华
上海中医药大学附属曙光医院柏氏肛肠科，上海 200023
Author(s):
ZHANG Dongmei, ZHANG Yaming, XIA Zehua
Department of Bai's Anorectal Surgery, Shuguang Hospital Affiliated to Shanghai University of TCM, Shanghai 200023, China
关键词:
溃疡性结肠炎; 肠型脂肪酸结合蛋白; 可溶性晚期糖基化终末产物受体; 核周型抗中性粒细胞抗体; 清肠愈疡汤方
Keywords:
ulcerative colitis; I-FABP; sRAGE; p-ANCA; decoction
分类号:
R285
DOI:
10.12174/j.issn.2096-9600.2021.03.04
摘要:
目的观察清肠愈疡汤口服及中药灌肠联合美沙拉嗪治疗溃疡性结肠炎的临床疗效及其对血清肠型脂肪酸结合蛋白（intestinal fatty acid binding protein，I-FABP）、可溶性晚期糖基化终末产物受体（soluble receptor for advanced glycation endproducts，sRAGE）和核周型抗中性粒细胞抗体（perinuclear antineutrophil cytoplasmic antibody，p-ANCA）水平的影响。 方法将溃疡性结肠炎患者124例根据随机数字表法分为观察组和对照组各62例。对照组予美沙拉嗪治疗，观察组在对照组基础上予清肠愈疡汤口服和中药灌肠治疗。观察两组临床疗效及治疗前后临床症状评分、肠镜下黏膜评分、Sutherland DAI评分、组织病理评分，并观察全血黏度及I-FABP、sRAGE和p-ANCA水平变化情况。 结果总有效率观察组为95.2%（59/62），高于对照组的80.6%（50/62）（χ2=4.854，P＜0.05）。治疗后两组患者临床症状评分、肠镜下黏膜评分、Sutherland DAI评分、组织病理评分、全血黏度及I-FABP、sRAGE和p-ANCA水平均较治疗前降低（P＜0.01），观察组降低更明显（P＜0.01）。 结论清肠愈疡汤口服及中药灌肠联合美沙拉嗪能促进溃疡性结肠炎患者结肠黏膜损伤愈合，降低血液黏度，其机制可能与降低血清I-FABP、sRAGE和p-ANCA水平有关。
Abstract:
ObjectiveTo observe clinical effects of oral administration of Qingchang Yuyang decoction and herbal enema combined with mesalazine in treating ulcerative colitis (UC), and its influence on the levels of I-FABP, sRAGE and p-ANCA. MethodsAll 124 UC patients were allocated to the observation group and the control group according to random number table method, 62 cases each group. The control group were treated by mesalazine, the observation group by oral administration of Qingchang Yuyang decoction and herbal enema on the foundation of Western medicine. To observe clinical effects, clinical symptom integrals, endoscopic submucosal score, Sutherland DAI scores and histopathological score before and after treating between both groups, to observe the levels of whole blood viscosity, I-FABP, sRAGE and p-ANCA. ResultsTotal effective rate of the observation group was 95.2%(59/62), higher than 80.6%(50/62) of the control group (χ2=4.854, P<0.05). After treating, clinical symptom integrals, endoscopic submucosal score, Sutherland DAI scores and histopathological score, the levels of whole blood viscosity, I-FABP, sRAGE and p-ANCA of both groups lowered than before treating (P<0.01), the decrease of the observation group was more notable (P<0.01). ConclusionOral administration of Qingchang Yuyang decoction and herbal enema combined with mesalazine could promote the healing of colonic mucosal injury and lower blood viscosity in treating UC patients, and its mechanism might be related to lowering the levels of I-FABP, sRAGE and p-ANCA.

相似文献/References:

[1]李明彦,刘召.三黄汤口服并灌肠治疗溃疡性结肠炎临床观察[J].西部中医药,2014,27(11):127.
[2]崔童.肠安康胶囊联合美沙拉嗪治疗溃疡性结肠炎疗效观察[J].西部中医药,2015,28(01):78.
[3]孙军刚,刘琦,吴巧凤△.针刺对溃疡性结肠炎Th17/Treg免疫平衡的调节作用[J].西部中医药,2015,28(01):129.
[4]杨斌,王碧霞.美沙拉嗪栓联合穴位贴治疗溃疡性结肠炎中期效果探讨[J].西部中医药,2015,28(05):112.
[5]张军,叶玉伟.中医药治疗溃疡性结肠炎研究进展概况[J].西部中医药,2013,26(12):150.
　ZHANG Jun,YE Yuwei.A Survey of TCM in Treating Ulcerative Colitis[J].Western Journal of Traditional Chinese Medicine,2013,26(03):150.
[6]陈晨.中药保留灌肠治疗急性期溃疡性结肠炎的研究[J].西部中医药,2014,27(05):135.
　CHEN Chen.Research on Retention Enema with Herbs in Treating Ulcerative Colitis at Acute Exacerbation Stage[J].Western Journal of Traditional Chinese Medicine,2014,27(03):135.
[7]李有成,严文有,陈俊英,等.加味阳和四神汤/浸膏剂治疗慢性溃疡性结肠炎疗效观察[J].西部中医药,2014,27(05):104.
　LI Youcheng,YAN Wenyou,CHEN Junying,et al.Observation on Modified YangHe SiShen Decoction or Extract in Treating Chronic Ulcerative Colitis[J].Western Journal of Traditional Chinese Medicine,2014,27(03):104.
[8]王福亭.致康胶囊对溃疡性结肠炎患者血清TNF-α、IL-6及CRP的影响[J].西部中医药,2016,29(02):100.
　WANG Futing.Influence of ZhiKang Capsules on Serum TNF-α, IL-6 and CRP of the Patients with Ulcerative Colitis[J].Western Journal of Traditional Chinese Medicine,2016,29(03):100.
[9]张亮,王玮,邱连利△.温通针法治疗脾肾阳虚型溃疡性结肠炎35例[J].西部中医药,2017,30(12):100.
　ZHANG Liang,WANG Wei,QIU Lianli.Warming Needling Method in Treating 35 Cases of Ulcerative Colitis of Spleen-kidney Yang-deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2017,30(03):100.
[10]周春芳.强肝软坚汤加味治疗溃疡性结肠炎机制研究[J].西部中医药,2018,31(03):97.
　ZHOU Chunfang.Study on the Mechanism of Modified Liver-strengthening Mass-softening Decoction in Treating Ulcerative Colitis[J].Western Journal of Traditional Chinese Medicine,2018,31(03):97.

备注/Memo

备注/Memo:
张冬梅（1979—），女，硕士学位，主治医师。研究方向：中医肛肠病学。上海市进一步加快中医药事业发展三年行动计划（2018—2020年）项目［ZY（2018-2020）-CCCX-1004］。
更新日期/Last Update: 2021-03-05