[1]刘孟楠,罗钢,刘平,等.蛭龙活血通瘀胶囊对家兔颈动脉粥样硬化斑块组织p-NF-κB、NLRP3表达的影响[J].西部中医药,2021,34(03):25-29.[doi:10.12174/j.issn.2096-9600.2021.03.06]
　LIU Mengnan,LUO Gang,LIU Ping,et al.Influences of Zhilong Huoxue Tongyu Capsules on the Expressions of p-NF-κB and NLRP3 in Carotid Atherosclerotic Plaque in Rabbit[J].Western Journal of Traditional Chinese Medicine,2021,34(03):25-29.[doi:10.12174/j.issn.2096-9600.2021.03.06]
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蛭龙活血通瘀胶囊对家兔颈动脉粥样硬化斑块组织p-NF-κB、NLRP3表达的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年03期
页码:
25-29
栏目:
出版日期:
2021-03-15

文章信息/Info

Title:
Influences of Zhilong Huoxue Tongyu Capsules on the Expressions of p-NF-κB and NLRP3 in Carotid Atherosclerotic Plaque in Rabbit
作者:
刘孟楠1,2, 罗钢1, 刘平1, 刘佳利1, 刘颜1, 周华2, 杨思进1,2
1.西南医科大学附属中医医院心血管内科，四川 泸州 646000
2.澳门科技大学中医药学院
Author(s):
LIU Mengnan1,2, LUO Gang1, LIU Ping1, LIU Jiali1, LIU Yan1, ZHOU Hua2, YANG Sijin1,2
1.Department of Cardiovascular Disease, Affiliated TCM Hospital of Southwest Medical University, Luzhou 646000, China
2.School of Materia Medica, Macau University of Science and Technology
关键词:
动脉粥样硬化; 血脂; 核转录因子B; NLRP3; 蛭龙活血通瘀胶囊; 家兔
Keywords:
atherosclerosis; blood lipid; NF-B; NLRP3; capsules; rabbit
分类号:
R285.5
DOI:
10.12174/j.issn.2096-9600.2021.03.06
摘要:
目的探讨蛭龙活血通瘀胶囊对家兔颈动脉粥样硬化斑块组织p-NF-κB、NLRP3的影响。 方法将40只雌雄各半的清洁级新西兰大白兔随机分为正常组、模型组、蛭龙活血通瘀胶囊组、阿托伐他汀组、蛭龙活血通瘀胶囊+阿托伐他汀组，每组8只。各组经适应性普通饲料喂养1周后，除正常组外其余各组行右侧颈动脉内膜空气干燥术，术后继续高脂饲料喂养4周建立兔颈动脉粥样硬化模型，正常组普通饲料喂养。实验第5周末处死家兔，检查各组家兔血脂、颈动脉p-NF-κB、NLRP3蛋白表达，观察颈动脉病变情况。 结果与模型组比较，蛭龙活血通瘀胶囊和阿托伐他汀均可降低模型家兔血清总胆固醇(total cholesterol，TC)和甘油三酯(triglyceride，TG)（P＜0.01），降低p-NF-κB、NLRP3蛋白在颈动脉组织中的表达（P＜0.01），不同程度改善颈动脉病变情况，且蛭龙活血通瘀胶囊+阿托伐他汀组作用更明显。 结论蛭龙活血通瘀胶囊可降低p-NF-κB、NLRP3蛋白在高脂血症劲动脉粥样硬化家兔颈动脉组织中的表达，降低模型家兔血脂，改善颈动脉粥样硬化，且与阿托伐他汀联用效果更佳。
Abstract:
ObjectiveTo explore the effects of Zhilong Huoxue Tongyu capsules on the expressions of p-NF-κB and NLRP3 in carotid atherosclerotic plaque in rabbit. MethodsForty New Zealand white rabbits, half male and female were randomized into the normal group, the model group, Zhilong Huoxue Tongyu capsules group, atorvastatin group, Zhilong Huoxue Tongyu capsules+atorvastatin group, eight rabbits each group. After one week of adaptive common diet, all the groups received air drying of the right carotid artery intima except the normal group after the operation, the rabbits were fed with high-fat diet for four weeks to establish carotid atherosclerosis model, the normal group were fed with common diet. The rabbits were sacrificed by the end of the 5th week, to detect the levels of blood lipid, the expressions of p-NF-κB and NLRP3 in carotid artery in different groups, to observe pathological changes of carotid artery. ResultsCompared with the model group, Zhilong Huoxue Tongyu capsules and atorvastatin could lower the levels of TC and TG in rabbit models (P<0.01), lower the expressions of p-NF-κB and NLRP3 protein in carotid artery (P<0.01), improve carotid artery disease to different degrees, and the effects of Zhilong Huoxue Tongyu capsules+atorvastatin group the most notable. ConclusionZhilong Huoxue Tongyu capsules could lower the expressions of p-NF-κB and NLRP3 protein in carotid artery in atherosclerotic rabbits, decrease the levels of blood lipid in rabbit models, improve carotid atherosclerosis, and its effects the best in its combination with atorvastatin.

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备注/Memo

备注/Memo:
刘孟楠（1994—），男，在读博士研究生，医师。研究方向：心脑血管疾病的中西医结合防治。国家自然科学基金（82074378）；2018年西南医科大学-西南医科大学附属中医医院联合项目（2018XYLH-005）;2018年四川省科技计划—重点研发计划（重大科技专项）项目（2018SZ0060）；2019年泸州市科技计划项目（2019-RCM-95）。
更新日期/Last Update: 2021-03-05