[1]朱心怡,王琪,赵赟霄,等.三七抗血小板聚集及抗凝作用机制研究[J].西部中医药,2021,34(08):21-24.[doi:10.12174/j.issn.2096-9600.2021.08.05]
　ZHU Xinyi,WANG Qi,ZHAO Yunxiao,et al.Study on Antiplatelet and Anticoagulant Mechanism of Sanqi[J].Western Journal of Traditional Chinese Medicine,2021,34(08):21-24.[doi:10.12174/j.issn.2096-9600.2021.08.05]
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三七抗血小板聚集及抗凝作用机制研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年08期
页码:
21-24
栏目:
出版日期:
2021-08-15

文章信息/Info

Title:
Study on Antiplatelet and Anticoagulant Mechanism of Sanqi
作者:
朱心怡1,2,3,4, 王琪1, 赵赟霄1,2,3, 宋雅雅1,2,3, 张威1,2,3, 赵益明1,2,3
1.苏州大学附属第一医院，江苏 苏州 215006
2.江苏省血液研究所
3.卫生部血栓与止血重点实验室
4.盐城市第一人民医院
Author(s):
ZHU Xinyi1,2,3,4, WANG Qi1, ZHAO Yunxiao1,2,3, SONG Yaya1,2,3, ZHANG Wei1,2,3, ZHAO Yiming1,2,3
1.The First Affiliated Hospital of Soochow University, Suzhou 215006, China
2.Jiangsu Institute of Hematology
3.Key Laboratory of Thrombosis and Hemostasis, Ministry of health
4.Yancheng City First People's Hospital
关键词:
三七; 血小板; 活化; 聚集; 抗凝
Keywords:
platelet; activation; aggregation; anticoagulant
分类号:
R285
DOI:
10.12174/j.issn.2096-9600.2021.08.05
摘要:
目的探讨中药三七抗血小板聚集和抗凝的作用机制。 方法征集10例志愿者，每日口服三七3 g，连续服用5日。比较服药前后经由胶原（collgen，COL）、肾上腺素（epinephrine，EPI）、二磷酸腺苷（adenosine diphosphate，ADP）和花生四烯酸（arachidonic acid，AA）所诱导的血小板聚集率（maximum platelet aggregation rate，MAR），比较血浆中血管性血友病因子抗原（von willebrand factor antigen，VWF：Ag）、P-选择素（Pselectin）含量，凝血酶时间（thrombin time，TT），活化部分凝血活酶时间（activated partial thromboplastin time，APTT）及凝血酶原时间（prothrombin time，PT）。 结果与服药前相比，MAR在第3、6日均显著下降（P＜0.05），服药后第6日血浆VWF：Ag和P-选择素的含量显著下降（P＜0.05），服药后第6日，TT、APTT、PT均延长（P＜0.05）。 结论三七主要通过抑制血小板黏附、聚集和释放的作用起到抗血栓的作用，兼有抗凝作用。
Abstract:
ObjectiveTo discuss antiplatelet and anticoagulant mechanism of Sanqi (Panax notoginsengin). MethodsTen volunteers were recruited and took Sanqi orally each day, for five days consecutively, to compare MAR induced by COL,EPI,ADP,and AA before and after medication,to compare the contents of P selectin and VWF:Ag,TT,APTT and PT. ResultsCompared with before the medication, MAR lowered at the 3rd and 6th day after taking Sanqi notably (P<0.05). The contents of VWF:Ag and P selectin reduced notaly in the plasma at the 6th day after medication than these before the medication (P<0.05). TT, APTT and PT prolonged at the 6th day after medication (P<0.05). ConclusionSanqi could develop antithrombotic and anticoagulant effects through inhibiting platelet adhesion, aggregation and release.

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备注/Memo

备注/Memo:
朱心怡（1995—），女，硕士学位，初级检验师。研究方向：止血与血栓。
更新日期/Last Update: 2021-08-15