[1]梁新梅,龚胜男,黎军宏,等.基于阳虚理论论治失眠的临床疗效Meta分析[J].西部中医药,2021,34(08):66-71.[doi:10.12174/j.issn.2096-9600.2021.08.15]
　LIANG Xinmei,GONG Shengnan,LI Junhong,et al.Meta Analysis on Clinical Effects of Treating Insomnia from Yang Deficiency[J].Western Journal of Traditional Chinese Medicine,2021,34(08):66-71.[doi:10.12174/j.issn.2096-9600.2021.08.15]
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基于阳虚理论论治失眠的临床疗效Meta分析

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年08期
页码:
66-71
栏目:
出版日期:
2021-08-15

文章信息/Info

Title:
Meta Analysis on Clinical Effects of Treating Insomnia from Yang Deficiency
作者:
梁新梅1, 龚胜男1, 黎军宏2, 吴金桂1, 陈炜2, 苟尧1
1.广西中医药大学，广西 南宁 530001
2.广西中医药大学第一附属医院
Author(s):
LIANG Xinmei1, GONG Shengnan1, LI Junhong2, WU Jingui1, CHEN Wei2, GOU Yao1
1.Guangxi University of Chinese Medicine, Nanning 530001, China
2.The First Affiliated Hospital of Guangxi University of Chinese Medicine
关键词:
阳虚论治; 失眠; Meta分析; 随机对照试验
Keywords:
treating from deficiency; insomnia; Meta analysis; randomized controlled trials
分类号:
R256.23
DOI:
10.12174/j.issn.2096-9600.2021.08.15
摘要:
目的系统评价基于阳虚理论论治失眠的临床疗效和安全性。 方法检索知网、万方、维普、PubMed、Embase共5个数据库，检索时限从建库至2019年3月，纳入有关中药从阳虚论治失眠的随机对照试验。由两名研究者独立地对按纳入的文献进行严格筛选、提取数据和评价资料。用RevMan 5.3软件对纳入文献进行Meta分析。 结果最终纳入11项研究，共936名阳虚失眠患者。Meta分析显示中药从阳虚论治失眠的观察组临床疗效高于西药治疗的对照组［OR=1.63，95％CI（1.08，2.46），P=0.02］；匹兹堡睡眠质量指数评分（pittsburgh sleep quality index score，PSQI）显示，观察组与对照组评分比较，差异具有统计学意义［WMD=-1.24，95%CI（-1.89，-0.59），P=0.000 2］；在中医证候评分方面，观察组优于对照组［MDW=-3.48，95%CI（-5.40，-1.57，P=0.000 4］；并且观察组较对照组不良反应发生率较低［OR=0.06，95％CI（0.01，0.25），P=0.000 2］。 结论中医从阳虚理论论治失眠具有临床疗效显著、不良反应少的特点，但鉴于本研究纳入的文献数量少，质量相对低下，故未来需要更多的多中心、大样本、高质量的相关研究来进一步验证其有效性和安全性。
Abstract:
ObjectiveTo systematically assess clinical effects and the safety of treating insomnia from Yang deficiency. MethodsRandomized controlled trials (RCTs) on treating insomnia with herbs from Yang deficiency were searched in five databases including CNKI, Wanfang, VIP, PubMed and Embase from database building to March, 2019. Two researchers independently screened, extracted and evaluated the literatures according to the inclusion and exclusion criteria. Meta analysis was performed with Revman software 5.3. ResultsConsequently, 11 studies involving 936 insomnia patients of Yang deficiency pattern were included. Meta analysis showed that clinical effects of treating insomnia with herbs from Yang deficiency of the observation group were higher than these of the control group [OR=1.63,95%CI（1.08,2.46）,P=0.02], PSQI detection displayed that the scores of the observation group lowered compared with these of the control group, and the difference had statistical meaning[WMD=-1.24, 95%CI（-1.89,-0.59],P=0.000 2], The observation group was better than the control group in TCM syndrome integrals[MDW=-3.48, 95%CI（-5.40, -1.57,P=0.0004],the incidence of the observation group was lower than that of the control group[OR=0.06, 95% CI （0.01, 0.25）, P=0.000 2]. ConclusionTreating insomnia from Yang deficiency has the characteristics of significant clinical effect and less adverse reactions, However, in view of the small number and low quality of the included literatures, more multi center, large sample and high-quality researches on the treatment of insomnia from Yang deficiency are needed to further verify its effectiveness and safety.

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备注/Memo

备注/Memo:
梁新梅（1993—），女，硕士学位，医师。研究方向：老年病的中医药防治。广西科技计划项目重点研发计划（桂科AB16380324-02））；广西中医基础研究重点实验室系统课题（16-380-58-06）；广西中医药大学岐黄工程高层次人才团队培育项目（2018003）。
更新日期/Last Update: 2021-08-15