j.issn.2096-9600.2021.09.40]
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肝肾亏虚型退行性腰椎椎管狭窄症相关基因多态性的研究进展

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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

Title:: Research Progress of Related Gene Polymorphisms in Degenerative Lumbar Spinal Stenosis of Liver and Kidney Deficiency Pattern

作者:: 罗林钊¹, 邓强², 张彦军², 郭铁峰², 杜凯然¹, 魏美娟³, 刘晓雪¹, 李家明¹; 1.甘肃中医药大学，甘肃兰州 730030
2.甘肃省中医院
3.青海大学

Author(s):: LUO Linzhao¹, DENG Qiang², ZHANG Yanjun², GUO Tiefeng², DU Kairan¹, WEI Meijuan³, LIU Xiaoxue¹, LI Jiaming¹; 1.Gansu University of Traditional Chinese Medicine, Lanzhou 730030, China
2.Gansu Provincial Hospital of Traditional Chinese Medicine
3.Qinghai University

Keywords:: lumbar spinal stenosis; gene polymorphism; liver and kidney deficiency; review

摘要:: 从退行性腰椎椎管狭窄症（degenerative lumbar spinal stenosis，DLSS）相关中医证型的发病机制研究及DLSS与基因多态性的相关性研究入手探讨肝肾亏虚型DLSS的相关基因多态性，指出基于椎间盘退变机制的营养、生物力学、遗传学及分子生物学等致病原因，其中与其可能存在紧密关系的基因有HOX基因家族、胶原蛋白基因家族、上皮细胞膜蛋白（EMP-1）基因、Sox9基因、Pax1基因、TGF-β等，而肝肾亏虚型DLSS症状表现与其基因多态性可能存在关联性，可根据中医辨证论治理论，结合现代基因组学研究方法，进一步探讨肝肾亏虚型DLSS患者椎间盘、骨骼细胞、蛋白等变化，为DLSS早期辨体、辨证及施治提供科学依据。

Abstract:: The paper discusses the related gene polymorphism of degenerative lumbar spinal stenosis (DLSS) of liver and kidney deficiency pattern from the study on the pathogenesis of the related TCM patterns of DLSS and the correlation study between DLSS and gene polymorphism, it points out that, among them, the genes might be closely related to pathogenic causes of DLSS including nutrition, biomechanics, genetics and molecular biology of the mechanism of intervertebral disc degeneration, containing HOX gene family, collagen gene family, epithelial membrane protein (EMP-1) gene, Sox9 gene, Pax1 gene, TGF-βand others, while the symptoms and manifestations of DLSS of liver and kidney deficiency pattern may be associated with its gene polymorphism, according to TCM theory of syndrome differentiation and treatment, combined with modern genomics research methods, we can further study and explore the changes of intervertebral disc, skeletal cells and protein in patients with DLSS of liver and kidney deficiency pattern, so as to provide scientific basis for early identification, syndrome differentiation and treatment of DLSS.

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备注/Memo:: 罗林钊（1997—），男，在读硕士研究生。研究方向：脊柱疾病的中医药防治。甘肃省卫生行业科研计划项目（GSWSKY2016-01）。

更新日期/Last Update: 2021-09-15