[1]李姝蒙,刘忠瀚,殷晓辉,等.基于旷场实验探究二十味沉香丸对卒中后PTSD模型大鼠的调节作用[J].西部中医药,2021,34(10):16-19.[doi:10.12174/j.issn.2096-9600.2021.10.04]
　LI Shumeng,LIU Zhonghan,YIN Xiaohui,et al.Regulatory Effects of Ershiwei Chenxiang Pills on PTSD Rat Models Based on Open Field Experiment[J].Western Journal of Traditional Chinese Medicine,2021,34(10):16-19.[doi:10.12174/j.issn.2096-9600.2021.10.04]
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基于旷场实验探究二十味沉香丸对卒中后PTSD模型大鼠的调节作用
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年10期
页码:
16-19
栏目:
出版日期:
2021-10-15

文章信息/Info

Title:
Regulatory Effects of Ershiwei Chenxiang Pills on PTSD Rat Models Based on Open Field Experiment
作者:
李姝蒙1,2, 刘忠瀚1,2, 殷晓辉1,2, 俞邦1, 朱泠霏1,2, 武慧超1, 毛萌1
1.北京中医药大学，北京 100029
2.首都医科大学附属北京中医医院
Author(s):
LI Shumeng1,2, LIU Zhonghan1,2, YIN Xiaohui1,2, YU Bang1, ZHU Lingfei1,2, WU Huichao1, MAO Meng1
1.Beijing University of Chinese Medicine, Beijing 100029, China
2.Beijing Hospital of Traditional Chinese Medicine, Capital Medical University
关键词:
创伤后应激障碍; 二十味沉香丸; 旷场实验; 动物实验
Keywords:
PTSD; pills; open field experiment; zoopery
分类号:
R255.2
DOI:
10.12174/j.issn.2096-9600.2021.10.04
摘要:
目的观察二十味沉香丸对卒中后创伤后应激障碍（post traumatic stress disorder，PTSD）模型大鼠的调节作用。 方法将42只大鼠随机分为正常组、假手术组、模型组、二十味沉香丸组、帕罗西汀组。正常组及假手术组每组6只，模型组、二十味沉香丸组及帕罗西汀组每组10只。造模后2周，每天分别给予相对应的药物或生理盐水进行灌胃，静养1周后进行旷场实验，检测各组间大鼠行为学变化。 结果运动总距离、穿格次数，模型组与正常组比较差异有统计学意义（P＜0.05）；运动总距离、穿格次数、直立次数、直立时间、修饰次数及修饰时间，模型组与假手术组比较，差异有统计学意义（P＜0.05）；运动总距离、穿格次数、直立次数及直立时间，二十味沉香丸组与模型组比较差异有统计学意义（P＜0.05）；运动总距离、穿格次数及直立次数，帕罗西汀组与模型组比较，差异均有统计学意义（P＜0.05）。 结论二十味沉香丸对卒中后PTSD模型大鼠焦虑样行为具有一定的改善作用。
Abstract:
ObjectiveTo observe the regulatory effects of Ershiwei Chenxiang pills on rat model with PTSD. MethodsAll 42 rats were randomized into the normal group, sham operation group, the model group, Ershiwei Chenxiang pills group and paroxetine group, six rats in the normal group and sham operation group, ten rats in the model group, Ershiwei Chenxiang pills group and paroxetine group. Within two weeks after successfully modeling, the rats were drenched with the corresponding medicine or physiological saline respectively, after a week of rest, open field experiment was used to detect behavioral changes of rats in different groups. ResultsThe difference had statistical meaning between the model group and the normal group in the total distance and the times of crossing (P<0.05); the difference was statistically significant between the model group and sham operation group in the total distance, the times of crossing, standing times, standing time, modification times and modification time (P<0.05); the difference was significant between Ershiwei Chenxiang pills group and the model group in the total distance, the times of crossing, standing times, standing time (P<0.05); the difference had statistical meaning between paroxetine group and the model group in the total distance, the times of crossing, standing times (P<0.05). ConclusionErshiwei Chenxiang pills could improve anxiety like behavior in PTSD rat models to a certain degree.

相似文献/References:

[1]刘祥敏,张先庚△,薛秒.PTSD睡眠障碍流行病学及中医调护研究进展[J].西部中医药,2018,31(09):146.
　LIU Xiangmin,ZHANG Xiangeng,XUE Miao.Research Progress on TCM Nursing and Epidemiology of Sleep Disorder of PTSD Patients[J].Western Journal of Traditional Chinese Medicine,2018,31(10):146.
[2]彭晓明,唐珂,高丽波,等.金匮肾气丸治疗创伤后应激障碍的临床疗效观察[J].西部中医药,2021,34(06):95.[doi:10.12174/j.issn.2096-9600.2021.06.23]
　PENG Xiaoming,TANG Ke,GAO Libo,et al.Observation on Clinical Effects of Jingui Shenqi Pills in the Treatment of Post-traumatic Stress Disorder[J].Western Journal of Traditional Chinese Medicine,2021,34(10):95.[doi:10.12174/j.issn.2096-9600.2021.06.23]

备注/Memo

备注/Memo:
李姝蒙（1999—），女，在读硕士研究生。研究方向：神经精神疾病病证结合研究。国家自然科学基金青年科学基金（81403498）；青年教师项目基金课题（2019-Jyb-JS-001）；国家级大学生创新创业训练项目（201910026006）。
更新日期/Last Update: 2021-10-15