[1]苏金妹,卢秋玉,唐爱存.葫芦茶水提物镇咳祛痰平喘作用的实验研究[J].西部中医药,2021,34(10):44-47.[doi:10.12174/j.issn.2096-9600.2021.10.10]
　SU Jinmei,LU Qiuyu,TANG Aicun.Experimental Study on Antitussive, Expectorant and Antiasthmatic Actions of Aqueous Extract of Hulucha[J].Western Journal of Traditional Chinese Medicine,2021,34(10):44-47.[doi:10.12174/j.issn.2096-9600.2021.10.10]
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葫芦茶水提物镇咳祛痰平喘作用的实验研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年10期
页码:
44-47
栏目:
出版日期:
2021-10-15

文章信息/Info

Title:
Experimental Study on Antitussive, Expectorant and Antiasthmatic Actions of Aqueous Extract of Hulucha
作者:
苏金妹1, 卢秋玉2, 唐爱存3
1.广西国际壮医医院明秀分院，广西 南宁 530001
2.广西壮族自治区人民医院药学部
3.广西中医药大学第一附属医院药学部
Author(s):
SU Jinmei1, LU Qiuyu2, TANG Aicun3
1.Mingxiu Branch, Guangxi International Zhuang Medicine Hospital, Nanning 530001, China
2.Department of Pharmacy, The People′s Hospital of Guangxi Zhuang Autonomous Region
3.Department of Pharmacy, the First Affiliated Hospital of Guangxi Univers
关键词:
葫芦茶水提物; 镇咳; 祛痰; 平喘; 动物实验
Keywords:
aqueous extract of; antitussive action; expectorant action; antiasthmatic action; zoopery
分类号:
R441.5
DOI:
10.12174/j.issn.2096-9600.2021.10.10
摘要:
目的研究葫芦茶水提取物镇咳、祛痰、平喘的药效学作用。 方法分别以昆明种小鼠、Wistar大鼠和豚鼠为实验动物，采用小鼠氨水引咳法和豚鼠枸橼酸引咳法观察葫芦茶水提物的镇咳作用，采用小鼠酚红祛痰法和大鼠毛细管祛痰法观察其祛痰效果，采用豚鼠组胺引喘法观察其平喘作用。 结果与模型组比较，葫芦茶水提物高、中剂量组对浓氨水致小鼠咳嗽反应的咳嗽潜伏期显著延长，2 min内咳嗽次数显著减少（P＜0.05），而葫芦茶水提物低剂量组效果不明显（P＞0.05）；葫芦茶水提物高、中低剂量组对枸橼酸致豚鼠咳嗽反应的咳嗽潜伏期显著延长，5 min内咳嗽次数显著减少（P＜0.05）；葫芦茶水提物高、中低剂量组小鼠的气管段酚红排泄量显著增加（P＜0.05）；葫芦茶水提物高、中低剂量组大鼠的排痰量显著增加（P＜0.05）；葫芦茶水提物高、中低剂量组可延长组胺致豚鼠哮喘潜伏期（P＜0.05）。 结论葫芦茶水提物具有镇咳、祛痰、平喘的作用。
Abstract:
ObjectiveTo investigate the antitussive, expectorant and antiasthmatic effects of aqueous extract of Hulucha (tadehagi triquetrum). MethodsKunming mice, Wistar rats and guinea pigs were employed respectively, ammonia induced cough in mice and citric acid induced cough in guinea pigs were used to observe the antitussive effects of aqueous extract of Hulucha, phenol red expectorant method in mice and capillary expectorant method in rats to explore its expectorant effects, and histamine induced asthma in guinea pigs to observe its antiasthmatic effects. ResultsCompared with the model group, the latency of cough induced by concentrated ammonia water was significantly prolonged in the high and moderate dosages groups of Hulucha, cough times reduced notably within two minutes, while the effects of low dose group of Hulucha was insignificant (P<0.05); the latency of cough induced by citric acid in guinea pigs was notably prolonged in the high and moderate dosages groups of Hulucha, cough times reduced notably within five minutes, phenol red excretion in trachea of the mice increased signficantly in the high and moderate dosages groups of Hulucha; sputum output of the rats increased notably in the high and moderate dosages groups of Hulucha; the latency of asthma induced by histamine was significantly prolonged in the high and moderate dosages groups of Hulucha(P<0.05). ConclusionAqueous extract of Hulucha owns the antitussive, expectorant and antiasthmatic effects.

备注/Memo

备注/Memo:
苏金妹（1984—），女，主管药师。研究方向：医院药学。广西自然科学基金（2015GXNSFBA139126）；广西卫生计生委研究项目（Z2015481；Z20170303）。
更新日期/Last Update: 2021-10-15