[1]李丽梅,王永强.参苓白术散联合美沙拉嗪治疗溃疡性结肠炎临床观察[J].西部中医药,2021,34(10):124-126.[doi:10.12174/j.issn.2096-9600.2021.10.31]
　LI Limei,WANG Yongqiang.Clinical Observation on Shenling Baizhu Powder and Mesalazine in Treating Ulcerative Colitis[J].Western Journal of Traditional Chinese Medicine,2021,34(10):124-126.[doi:10.12174/j.issn.2096-9600.2021.10.31]
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参苓白术散联合美沙拉嗪治疗溃疡性结肠炎临床观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年10期
页码:
124-126
栏目:
衷中参西
出版日期:
2021-10-15

文章信息/Info

Title:
Clinical Observation on Shenling Baizhu Powder and Mesalazine in Treating Ulcerative Colitis
作者:
李丽梅, 王永强
江苏大学附属昆山医院,江苏 昆山 215300
Author(s):
LI Limei, WANG Yongqiang
Kunshan Hospital Affiliated to Jiangsu University, Kunshan 215300, China
关键词:
溃疡性结肠炎; 参苓白术散; 美沙拉嗪; 炎症因子; 血沉; 血小板; D-二聚体
Keywords:
ulcerative colitis; powder; mesalazine; inflammatory factor; ESR; PLT; D-dimer
分类号:
R574
DOI:
10.12174/j.issn.2096-9600.2021.10.31
摘要:
目的观察参苓白术散联合美沙拉嗪治疗溃疡性结肠炎（ulcerative colitis，UC）的临床疗效及对相关血清指标的影响。 方法选择UC患者90例，随机分为对照组和观察组，每组45例。对照组给予美沙拉嗪治疗，观察组给予参苓白术散联合美沙拉嗪治疗，两组均连续治疗8周后评价并比较两组临床疗效及血清白细胞介素17（interleukin-17，IL-17）、白细胞介素23（interleukin-23，IL-23）、肿瘤坏死因子α（tumor necrosis factor-α，TNF-α）、血沉（erythrocyte sedimentation rate，ESR）、血小板（blood platelet，PLT）及D-二聚体水平。 结果总有效率观察组［88.89%（40/45）］优于对照组［71.11%（32/45）］（P＜0.05）；治疗后，两组血清IL-17、IL-23、TNF-α、D-二聚体及ESR、PLT水平均明显低于治疗前（P＜0.05），且观察组降低程度大于对照组（P＜0.05）。 结论参苓白术散联合美沙拉嗪治疗UC临床疗效显著，且可降低血清炎症因子、ESR、PLT及D-二聚体水平。
Abstract:
ObjectiveTo observe clinical effects of Shenling Baizhu powder and mesalazine in the treatment of ulcerative colitis (UC) and its effects on the related serum indexes. MethodsAll 90 UC patients were chosen and randomized into the control group and the observation group, 45 cases in each group. The control group was treated by mesalazine, and the observation group was treated by Shenling Baizhu powder and mesalazine, both groups were treated for eight weeks consecutively. To assess and compare clinical effects, the levels of IL-17, IL-23, TNF-α, ESR, PLT and D-dimer between both groups. ResultsTotal effective rate of the observation group was 88.89% (40/45), superior to 71.11% (32/45) of the control group (P<0.05); after treating, the levels of IL-17, IL-23, TNF-α, D-dimer, ESR and PLT of both groups were lower than these before treating(P<0.05), and the decrease of the observation group was greater than that of the control group (P<0.05). ConclusionShenling Baizhu powder and mesalazine could gain notable effects in the treatment of UC, it could reduce the levels of serum inflammatory factor, the levels of ESR, PLT and D-dimer.

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备注/Memo

备注/Memo:
李丽梅（1984—），女，硕士学位，副主任医师。研究方向：肛肠疾病的诊治。
更新日期/Last Update: 2021-10-15