[1]朱梦佳,蔡萌强,杨慧萍,等.小柴胡汤联合恩替卡韦治疗慢性乙型病毒性肝炎的Meta分析[J].西部中医药,2021,34(12):62-66.[doi:10.12174/j.issn.2096-9600.2021.12.17]
 ZHU Mengjia,CAI Mengqiang,YANG Huiping,et al.Meta Analysis of Xiaochaihu Decoction and Entecavir in the Treatment of Chronic Hepatitis B[J].Western Journal of Traditional Chinese Medicine,2021,34(12):62-66.[doi:10.12174/j.issn.2096-9600.2021.12.17]
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小柴胡汤联合恩替卡韦治疗慢性乙型病毒性肝炎的Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年12期
页码:
62-66
栏目:
循证医学
出版日期:
2021-12-15

文章信息/Info

Title:
Meta Analysis of Xiaochaihu Decoction and Entecavir in the Treatment of Chronic Hepatitis B
作者:
朱梦佳 蔡萌强 杨慧萍 王淋 赵文霞
河南中医药大学第一附属医院,河南 郑州 450000
Author(s):
ZHU Mengjia CAI Mengqiang YANG Huiping WANG Lin ZHAO Wenxia
The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
关键词:
小柴胡汤恩替卡韦慢性乙型肝炎随机对照试验Meta分析
Keywords:
decoctionentecavirCHBRCTMeta analysis
分类号:
R512.6+2
DOI:
10.12174/j.issn.2096-9600.2021.12.17
文献标志码:
A
摘要:
目的系统评价小柴胡汤联合恩替卡韦治疗慢性乙型肝炎(chronic hepatitis B,CHB)的有效性,为临床治疗提供循证参考。 方法计算机检索7个中英文数据库,筛选小柴胡汤联合恩替卡韦治疗慢性乙型肝炎的随机对照研究(randomized controlled trial,RCT),对其进行质量评价及资料提取,并采用Review Manager 5.3进行Meta分析。 结果共纳入10项RCT,共875例,包括治疗组437例,对照组438例。治疗组血清ALT复常率(RR=1.29,95%CI[1.18,1.44],P<0.000 01),血清HBeAg转阴率(RR=2.27,95%CI[1.68,3.08],P<0.000 01),血清HBV-DNA转阴率(RR=2.40,95%CI[1.73,3.33],P<0.000 01),临床疗效(RR=5.88,95%CI[3.48,9.93],P<0.000 01),应答率(RR=2.08,95%CI[1.47,2.97],P<0.000 1),以上指标治疗组均优于对照组。 结论小柴胡汤联合恩替卡韦治疗CHB,能有效改善患者肝功生化复常率,提高血清HBeAg及HBV-DNA转阴率,其临床疗效及应答率明显提高。
Abstract:
ObjectiveTo systematically assess the efficacy of Xiaochaihu decoction combined with entec-avir in treating CHB, so as to provide the evidence-based reference for clinical therapy. MethodsRCT about Xiaochaihu decoction and entecavir in treating CHB was screened in seven Chinese and English databases using computer, to perform the qualty evaluation and data extraction, Review Manager 5.3 was used to perform Meta analysis. ResultsAll ten RCTs were included, involving 875 cases, including 437 cases of the treatment group and 438 cases of the control group. The results showed that the normalization rate of serum ALT of the treatment group was (RR=1.29, 95%CI[1.18, 1.44], P<0.000 01), serum HBeAg negative conversion rate (RR=2.27, 95%CI[1.68, 3.08], P<0.000 01), serum HBV-DNA negative conversion rate (RR=2.40, 95%CI[1.73, 3.33], P<0.000 01), clinical effects (RR=5.88, 95%CI[3.48, 9.93], P<0.000 01), response rate (RR=2.08, 95%CI[1.47, 2.97], P<0.00001), the treatment group was better than the control group in the indexes above. ConclusionXiaochaihu decoction combined with entecavir in treating CHB could effectively improve biochemical normalization rate of liver function, lift serum HBeAg negative conversion rate and HBV-DNA negative conversion rate, its clinical effects and response rate significantly.

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备注/Memo

备注/Memo:
朱梦佳(1994—),女,在读硕士研究生。研究方向:消化系统疾病的中医药诊治。河南省自然科学基金(162300410183)。
更新日期/Last Update: 2021-12-15