[1]林慧,敖雪,刘永利,等.当归拈痛汤对湿热痹阻型膝骨性关节炎临床疗效及TNF-α、IL-1、NO的影响[J].西部中医药,2021,34(12):81-84.[doi:10.12174/j.issn.2096-9600.2021.12.21]
 LIN Hui,AO Xue,LIU Yongli,et al.Clinical Effects of Danggui Niantong Decoction in the Treatment of Knee Osteoarthritis of Damp-heat Obstructing Pattern and Its Influence on the Levels of TNF-α, IL-1 and NO[J].Western Journal of Traditional Chinese Medicine,2021,34(12):81-84.[doi:10.12174/j.issn.2096-9600.2021.12.21]
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当归拈痛汤对湿热痹阻型膝骨性关节炎临床疗效及TNF-α、IL-1、NO的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年12期
页码:
81-84
栏目:
临证经验
出版日期:
2021-12-15

文章信息/Info

Title:
Clinical Effects of Danggui Niantong Decoction in the Treatment of Knee Osteoarthritis of Damp-heat Obstructing Pattern and Its Influence on the Levels of TNF-α, IL-1 and NO
作者:
林慧1 敖雪2 刘永利13 周宗波1
1.海口市中医医院,海南 海口 570216
2.海口市人民医院
3.湖南中医药大学
Author(s):
LIN Hui1 AO Xue2 LIU Yongli13 ZHOU Zongbo1
1.Haikou City Hospital of Traditional Chinese Medicine, Haikou 570216, China
2.Haikou City People?s Hospital
3.Hunan University of Chinese Medicine
关键词:
骨性关节炎湿热痹阻型当归拈痛汤关节液肿瘤坏死因子α白细胞介素1一氧化氮
Keywords:
osteoarthritis kneedamp-heat obstructing patterndecoctionarticular fluidTNF-αIL-1NO
分类号:
R684.3
DOI:
10.12174/j.issn.2096-9600.2021.12.21
文献标志码:
B
摘要:
目的观察与评估当归拈痛汤治疗湿热痹阻型膝骨性关节炎(knee osteoarthritis,KOA)的疗效及对关节液肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素1(interleukin-1,IL-1)及一氧化氮(nitric oxide,NO)的影响。 方法将106例湿热痹阻型KOA患者按随机、对照的原则分为观察组和对照组,每组53例。观察组给予当归拈痛汤治疗,对照组给予盐酸氨基葡萄糖片治疗,两组均持续治疗4周。比较两组临床疗效、视觉模拟疼痛评分(visual analogue scales,VAS)、西安大略和麦克马斯特大学(Western Ontario and McMaster universities,WOMAC)骨关节炎指数评分量表评分,ELISA法检测关节液中TNF-α、IL-1、NO的含量。 结果观察组总有效率[88.79%(46/52)]与对照组总有效率[88.70%(45/52)]比较,差异无统计学意义(P>0.05)。治疗后,两组VAS、WOMAC评分,TNF-α、IL-1、NO水平均较治疗前明显降低(P<0.05),且上述指标观察组低于照组(P<0.05)。 结论当归拈痛汤可缓解湿热痹阻型KOA患者疼痛症状,改善膝关节活动功能,且可干预炎症反应,下调关节液中TNF-α、IL-1、NO含量,从而提高综合疗效,可能是治疗KOA的潜在作用机制。
Abstract:
ObjectiveTo observe and evaluate clinical effects of Danggui Niantong decoction in the treatment of KOA of damp-heat arthralgia and obstructing pattern and its influence on the levels of TNF-α, IL-1 and NO in articular fluid. MethodsAll 106 patients were allocated into the observation group and the control group according to the principle of randomization and control, 53 cases in each group. The observation group was treated with Danggui Niantong decoction, and the control group with glucosamine hydrochloride tablets, both groups were treated for four weeks consecutively. To compare clinical effects, VAS, WOMAC scores between both groups, ELISA method was used to detect the contents of TNF-α, IL-1 and NO in articular fluid. ResultsThe difference had no statistical meaning in the comparisons of total effective rates between the observation group [88.79%(46/52)] and the control group [88.70%(45/52)] (P>0.05); after treating, VAS, WOMAC scores, the levels of TNF-α, IL-1 and NO of both groups lowered notably compared with these before treating (P<0.05). the observation group was lower than the control group in the above indexes (P<0.05). ConclusionDanggui Niantong decoction could relieve the pain of KOA patients, improve knee movement function, and down regulate the levels of TNF-α, IL-1 and NO in articular fluid, intervene inflammatory reaction, thus to raise comprehensive effects, and that might be the potential mechanism of treating KOA.

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备注/Memo

备注/Memo:
林慧(1986—),男,主治医师。研究方向:骨与关节损伤的推拿与中医药防治。国家自然科学基金(81874476);海南省自然科学基金面上项目(20168322);海南省卫生计生行业科研项目(15A200057)。
更新日期/Last Update: 2021-12-15