[1]李苗华,陈懿榕,葛冰景,等.十宝润肠方治疗泻药依赖性便秘的疗效及作用机制[J].西部中医药,2021,34(12):95-98.[doi:10.12174/j.issn.2096-9600.2021.12.25]
 LI Miaohua,CHEN Yirong,GE Bingjing,et al.Probe into Clinical Effects of Shibao Runchang Prescription in Treating Laxative-dependent Constipation and Its Mechanism[J].Western Journal of Traditional Chinese Medicine,2021,34(12):95-98.[doi:10.12174/j.issn.2096-9600.2021.12.25]
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十宝润肠方治疗泻药依赖性便秘的疗效及作用机制
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年12期
页码:
95-98
栏目:
临证经验
出版日期:
2021-12-15

文章信息/Info

Title:
Probe into Clinical Effects of Shibao Runchang Prescription in Treating Laxative-dependent Constipation and Its Mechanism
作者:
李苗华1 陈懿榕2 葛冰景1 傅志泉1 李勇2 阙任烨1
1.上海中医药大学附属上海市中西医结合医院,上海 200082
2.上海中医药大学附属市中医医院
Author(s):
LI Miaohua1 CHEN Yirong2 GE Bingjing1 FU Zhiquan1 LI Yong2 QUE Renye1
1.Shanghai TCM-integrated Hospital, Shanghai University of TCM, Shanghai 200082, China
2.Shanghai City Hospital of Traditional Chinese Medicine
关键词:
便秘泻药依赖性十宝润肠方PAC-SYM便秘自评量表PAC-QOL便秘生活量表5-羟色胺
Keywords:
constipation laxative-dependentprescriptionPAC-SYM constipation self rating scalePAC-QOL constipation life scale5-HT
分类号:
R256.35
DOI:
10.12174/j.issn.2096-9600.2021.12.25
文献标志码:
B
摘要:
目的观察十宝润肠方治疗泻药依赖性便秘患者的临床疗效及作用机制。 方法选择泻药依赖性便秘患者60例,采用随机数字表法分为观察组和对照组,每组30例。观察组予十宝润肠方治疗,对照组予杜密克治疗,两组疗程均为4周。观察两组PAC-SYM便秘自评量表评分、PAC-QOL便秘生活量表评分及血清5-羟色胺(5-hydroxytryptamine,5-HT)水平。 结果对照组治疗后PAC-SYM量表评分中粪便性状及直肠症状有显著改善(P<0.05),但腹部症状无明显改善(P>0.05);观察组各维度评分均较治疗前改善(P<0.05),且在改善直肠症状及腹部症状方面疗效优于对照组(P<0.05)。两组PAC-QOL量表各维度评分均较治疗前降低(P<0.05),观察组生理状态及满意度评分均较对照组改善显著(P<0.05);两组心理状态及担忧度评分比较,差异无统计学意义(P>0.05)。观察组治疗后血清5-HT水平显著升高(P<0.05),对照组治疗后血清5-HT水平无明显变化(P>0.05),且观察组5-HT水平改善优于对照组(P<0.05)。 结论十宝润肠方治疗泻药依赖性便秘可明显改善患者临床症状,其作用可能与调节血清5-HT含量有关。
Abstract:
ObjectiveTo observe clinical effects of Shibao Runchang prescription in the treatment of laxative-dependent constipation and the possible mechanism. MethodsSixty patients were chosen, allocated to the observation group and the control group using random number table method, 30 cases in each group. The observation group was treated by Shibao Runchang prescription, and the control group by lactulose oral liquid, the course was four weeks for both groups. To observe PAC-SYM constipation self rating scale score, PAC-QOL constipation life scale score and the levels of 5-HT in the two groups. ResultsFecal property and rectal symptoms of PAC-SYM constipation self rating scale score have improved significantly in the control group after treating (P<0.05), while abdominal symptoms showed no obvious improvements (P>0.05); different dimensional scores of the observation group improved than these before treating (P<0.05), the observation group was better than the control group in improving rectal symptom and abdominal symptoms (P<0.05). The scores of different dimensions of PAC-QOL scale in the two groups lowered than before treating (P<0.05), the improve-ments of physiological status and satisfaction in the two groups were more notable than these of the control group (P<0.05); the difference had no statistical meaning in the scores of psychological state and worry between both groups (P>0.05). The levels of serum 5-HT in the observation group rose notably after treating (P<0.05), and it unchanged in the control group after treating (P>0.05), and the improvement of 5-HT in the observation group was better than that of the control group (P<0.05). ConclusionShibao Runchang prescription in the treatment of laxative-dependent constipation could notably improve clinical symptoms of the patients, and its effects might be related to regulating the contents of serum 5-HT.

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备注/Memo

备注/Memo:
李苗华(1980—),女,主治医师。研究方向:消化系统疾病的临床与基础研究。上海市青年科技英才扬帆计划(19YF1445200);上海市科委引导类项目(18401904000);虹口区“国医强优”中医药科研基金(HGY-KY-2018-20)。
更新日期/Last Update: 2021-12-15