[1]何珏,华宇,徐妍,等.HR-HPV持续感染患者中医证候分析及清肝益肾方的干预效果[J].西部中医药,2022,35(01):12-16.[doi:10.12174/j.issn.2096-9600.2022.01.03]
 HE Jue,HUA Yu,XU Yan,et al.Analysis of TCM Syndromes of the Patients with HR-HPV Persistent Infection and Intervention Effects of Liver-clearing Kidney-benefiting Prescription[J].Western Journal of Traditional Chinese Medicine,2022,35(01):12-16.[doi:10.12174/j.issn.2096-9600.2022.01.03]
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HR-HPV持续感染患者中医证候分析及清肝益肾方的干预效果
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年01期
页码:
12-16
栏目:
临床论著
出版日期:
2022-01-15

文章信息/Info

Title:
Analysis of TCM Syndromes of the Patients with HR-HPV Persistent Infection and Intervention Effects of Liver-clearing Kidney-benefiting Prescription
作者:
何珏1 华宇1 徐妍1 顾颖1 谷灿灿2 胡国华2
1.上海中医药大学附属第七人民医院妇产科,上海 200137
2.上海中医药大学附属市中医医院妇科
Author(s):
HE Jue1 HUA Yu1 XU Yan1 GU Ying1 GU Cancan2 HU Guohua2
1.Gynecology and Obstetrics, Seventh People’s Hospital of Shanghai University of TCM, Shanghai 200137, China
2.Gynecology, Shanghai Hospital of Traditional Chinese Medicine Affiliated to Shanghai University of TCM
关键词:
人类乳头瘤病毒持续感染中医证候清肝益肾临床观察
Keywords:
HPVpersistent infectionTCM patternsliver-clearing kidney-benefitingclinical observation
分类号:
R273.733
DOI:
10.12174/j.issn.2096-9600.2022.01.03
摘要:
目的分析高危亚型HPV(high-risk human papilloma virus,HR-HPV)持续感染患者中医证候分布特点,观察清肝益肾方联合辛复宁干预的临床疗效。 方法1)运用频数分析和聚类分析方法研究104例HR-HPV持续感染患者的中医证候特点。2)将104例HR-HPV持续感染患者随机分为观察组和对照组各52例。对照组隔日予重组人干扰素α2b阴道泡腾胶囊(辛复宁)阴道给药。观察组在对照组基础上予清肝益肾汤。干预3个月后观察两组临床有效率、中医证候积分及随访6月后HPV转阴率和复发率。 结果1)持续性HR-HPV感染患者中医证候分布大致为肝经湿热、肾气不固、肾精不足3个证型。2)观察组、对照组总有效率分别为96.15%、84.62%,差异有统计学意义(P<0.05)。3)治疗前后组内比较,观察组带下量多、腥臭、色黄、阴部瘙痒评分比较差异有统计学意义(P<0.05),对照组带下量多、色黄评分比较差异有统计学意义(P<0.05);治疗后观察组带下量多、腥臭评分差值与治疗前比较差异有统计学意义(P<0.05)。4)两组治疗3、6个月后人类乳头瘤病毒(human papilloma virus,HPV)转阴率比较差异有统计学意义(P<0.05);观察组治疗6个月后HPV复发率低于对照组(P<0.05)。 结论HR-HPV持续性感染基本符合以虚为本,以湿热为标的病理机制;清肝益肾方联合辛复宁在提高宫颈HR-HPV持续性感染患者HPV转阴率、远期复发率及改善湿热带下证候方面优于单纯应用辛复宁。
Abstract:
ObjectiveTo analyze the distribution characteristics of TCM patterns in patients with HR-HPV persistent infection, and observe clinical effects of liver-clearing kidney-benefiting prescription and recombinant human interferon α2b vaginal effervescent capsules(Xinfuning) intervention. Methods1) Frequency analysis and cluster analysis were used to analyze the characteristics of TCM patterns in 104 patients with HR-HPV persistent infection. 2) All 104 patients with HR-HPV persistent infection were randomized into the observation group and the control group, with 52 cases in each group. The control group accepted vaginal administration of recombinant human interferon α2b vaginal effervescent capsules every other day, and the observation group took liver-clearing kidney-benefiting prescription orally based on Western medicine. To observe clinical effective rate and TCM syndrome scores after three months of intervention, HPV negative-conversion rate and relapse rate after six-month follow-up. Results1)TCM patterns of the patients with HR-HPV persistent infection were damp heat of liver meridian, unconsolidation of the kidney-Qi, the deficiency of renal essence. 2)Total effective rates of the observation group were 96.15% and the control group were 84.62%, and the difference had statistical meaning (P<0.05). 3) The difference was statistically significant in the scores of leukorrhagia, fishy smell, yellowish leukorrhea, pudendal pruritus within the observation group before and after the treatment (P<0.05), the difference showed statistical meaning in the scores of leukorrhagia and yellowish leukorrhea in the control group (P<0.05); the difference showed statistical meaning in the scores of leukorrhagia, fishy smell in the observation group before and after treatment (P<0.05). 4)The difference had statistical meaning in HPV negative-conversion rate after three-month and six-month of treatment between both groups (P<0.05); HPV relapse rate of the observation group was lower than that of the control group after six-month treatment (P<0.05). ConclusionHR-HPV persistent infection basically conforms to the pathological mechanism of deficiency as root cause and damp heat as superficial cause. Liver-clearing kidney-benefiting prescription and Xinfuning are better than simple application of Xinfuning in lifting HPV negative-conversion rate and long-term recurrence rate, improving the symptoms of damp-heat leukorrhagia.

备注/Memo

备注/Memo:
何珏(1984—),女,博士学位,主治医师。研究方向:中医妇科。全国名老中医药专家传承工作室建设项目(MLZJGZS-2017003);上海市中医药事业发展三年行动计划项目(ZYSNXD-CC-MZY050);上海中医药大学第四期名老中医药专家学术经验研究工作室建设项目(SZYMZYGZS4020);上海市中医专科联盟建设项目[ZY(2018-2020)-FWTX-4005)];上海中医药大学预算内项目(2020LK077)。
更新日期/Last Update: 2022-01-15