[1]王磊,屈红,郑君,等.聚焦超声联合参菊洗剂对外阴上皮内非瘤样病变患者VEGF、ET-1的影响[J].西部中医药,2022,35(01):32-35.[doi:10.12174/j.issn.2096-9600.2022.01.07]
　WANG Lei,QU Hong,ZHENG Jun,et al.Effects of Focused Ultrasound Combined with Shenju Lotion on VEGF and ET-1 in Patients with Vulva Nonneoplastic Epithelial Disorders[J].Western Journal of Traditional Chinese Medicine,2022,35(01):32-35.[doi:10.12174/j.issn.2096-9600.2022.01.07]
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聚焦超声联合参菊洗剂对外阴上皮内非瘤样病变患者VEGF、ET-1的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年01期
页码:
32-35
栏目:
出版日期:
2022-01-15

文章信息/Info

Title:
Effects of Focused Ultrasound Combined with Shenju Lotion on VEGF and ET-1 in Patients with Vulva Nonneoplastic Epithelial Disorders
作者:
王磊1, 屈红1, 郑君1, 顾立萍1,2
1.甘肃省中医院,甘肃 兰州 730050
2.甘肃省中医药研究院
Author(s):
WANG Lei1, QU Hong1, ZHENG Jun1, GU Liping1,2
1.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
2.Gansu Provincial Academy of Chinese Medicine
关键词:
外阴上皮内非瘤样病变; 血管内皮生长因子; 内皮素1; 聚焦超声; 参菊洗剂
Keywords:
vulva nonneplastic epithelial disorders; VEGF; ET-1; focused ultrasound; lotion
分类号:
R655
DOI:
10.12174/j.issn.2096-9600.2022.01.07
摘要:
目的观察聚焦超声联合参菊洗剂对外阴上皮内非瘤样病变组织中血管内皮生长因子（vascular endothelial growth factor，VEGF）、内皮素1（endotelin-1，ET-1）的影响。 方法将外阴上皮内非瘤样病变患者60例随机分为对照组与观察组各30例。对照组使用聚焦超声治疗；观察组在对照组的基础上联合参菊洗剂外洗。采用免疫组化SP法检测两组患者治疗前及治疗3月后VEGF、ET-1表达情况。 结果治疗3月后两组患者外阴皮肤组织中VEGF表达均较治疗前改善，观察组改善优于对照组（P＜0.05）；治疗3月后两组患者外阴皮肤中ET-1表达均较治疗前降低，观察组低于对照组（P＜0.05）；两组治疗后微血管数明显增多，观察组增加更明显（P＜0.05）。 结论聚焦超声联合参菊洗剂可能通过改善外阴上皮内非瘤样病变皮肤的微循环障碍及降低组织中的瘙痒介质水平而发挥治疗作用。
Abstract:
ObjectiveTo observe the effects of focused ultrasound jointed with Shenju lotion on VEGF and ET-1 in patients with vulva nonneplastic epithelial disorders (NNED). MethodsSixty patients suffering NNED were randomly allocated to the control group and the observation group, 30 cases in each group. The control group was treated with focused ultrasound, and the observation group accepted Shenju lotion for external application based on focused ultrasound. To detect the expressions of VEGF and ET-1 before treating and three months after treating using immunohistochemical SP method. ResultsThree months after treating, the expressions of VEGF in vulvar skin tissue in both groups improved than before treating, the improvements of the observation group were better than these of the control group (P<0.05); three months after treating, the expressions of ET-1 in vulvar skin tissue in both groups lowered than before treating, the observation group was lower than the control group (P<0.05); the number of microvessels increased in both groups after treating, the increase of the observation group was more notable (P<0.05). ConclusionFocused ultrasound jointed with Shenju lotion could develop therapeutic effects possibly through improving microcirculation disorder of nonneoplastic skin in vulvar epithelium and lowering the levels of itching mediators in tissuess.

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备注/Memo

备注/Memo:
王磊（1973—），女，硕士学位，主任医师。研究方向：妇科内分泌疾病的中西医结合诊治。兰州市指导性计划项目（2019-ZD-123）。
更新日期/Last Update: 2022-01-15