[1]王健全,侯昕玥,亢泽峰,等.中药干预病理性近视黄斑出血临床疗效Meta分析[J].西部中医药,2022,35(01):88-92.[doi:10.12174/j.issn.2096-9600.2022.01.21]
 WANG Jianquan,HOU Xinyue,KANG Zefeng,et al.Meta Analysis of Clinical Effects of TCM in the Intervention for Macular Hemorrhage in Patients with Pathological Myopia[J].Western Journal of Traditional Chinese Medicine,2022,35(01):88-92.[doi:10.12174/j.issn.2096-9600.2022.01.21]
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中药干预病理性近视黄斑出血临床疗效Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年01期
页码:
88-92
栏目:
循证医学
出版日期:
2022-01-15

文章信息/Info

Title:
Meta Analysis of Clinical Effects of TCM in the Intervention for Macular Hemorrhage in Patients with Pathological Myopia
作者:
王健全 侯昕玥 亢泽峰 袁慧艳
中国中医科学院眼科医院,北京 100040
Author(s):
WANG Jianquan HOU Xinyue KANG Zefeng YUAN Huiyan
Eye Hospital, China Academy of Chinese Medical Sciences, Beijing 100040, China
关键词:
病理性近视黄斑出血Meta分析系统评价中医药
Keywords:
macular hemorrhage in patients with pathological myopiaMeta analysissystematic evaluationTCM
分类号:
R774
DOI:
10.12174/j.issn.2096-9600.2022.01.21
摘要:
目的系统评价病理性近视黄斑出血中药干预的临床效果及安全性,为病理性近视黄斑出血的中药治疗提供循证依据。 方法计算机检索知网、万方、中国生物医学库(CBM)、维普(VIP)、Pubmed、Embase、Cochrane数据库和手工检索(时间从建库至2020年10月),筛选符合纳入标准的随机对照试验,对纳入研究进行质量评价,采用RevMan5进行Meta分析。 结果纳入的9篇文献共包括686只眼,全部为中文文献。Meta分析结果显示,与对照组相比,中药治疗病理性近视黄斑出血在提高总体疗效(OR=2.73,95%CI[1.77,4.20],P<0.05)、促进黄斑区出血吸收(OR=5.17,95%CI[2.26,11.84],P<0.05)、降低视网膜中心厚度(MD=-1.86,95%CI[-2.49,-1.24],P<0.05)方面差异均有统计学意义(P<0.05)。在提高矫正视力(OR=2.82,95%CI[0.91,8.76],P>0.05)方面差异无统计学意义。9个研究主要治法为养血补精,活血行气,其余以活血通络、补脾益气为主。9个研究均未提及有不良反应出现。 结论中药治疗病理性近视黄斑出血能加快吸收黄斑区出血,降低视网膜中心厚度,在治疗病理性近视黄斑出血总体疗效方面有优势,治法多为养血补精,活血行气。中药干预效果优于单纯西药或手术治疗,但需要通过更多高质量试验提高研究水平。
Abstract:
ObjectiveTo provide evidence-based basis for TCM therapy of macular hymorrhage in patients with pathological myopia by systematically assessing clinical effects and the safety of TCM intervention for the disease. MethodsBy searching CNKI, Wanfang, CBM, VIP, Pubmed, Embase, Cochrane databases via computer and manual retrieval (the time from the establishment of the database to October 2020), RCTs that met the inclusion standard were screened, and the quality of the included studies was assessed, software RevMan5 was used to conduct Meta analysis. ResultsNine articles included contained 686 eyes, and all were Chinese literature. Meta analysis results showed, compared with the control group, herbal therapy for macular hemorrhage in patients with pathological myopia had statistical meaning in improving overall clinical effects (OR=2.73, 95%CI[1.77,4.20], P<0.05), promoting the absorption of macular hemorrhage (OR=5.17, 95%CI [2.26,11.84], P<0.05) and reducing central retinal thickness (MD=-1.86, 95%CI[-2.49,-1.24], P<0.05). The difference had no statistical meaning in improving corrected vision (OR=2.82, 95%CI[0.91, 8.76], P>0.05). Main therapeutic approaches in nine studies were nourishing blood and tonifying essence, activating blood and moving Qi, activating blood and dredging collateralls, invigorating spleen and tonifying Qi in the rest. No adverse reaction has been mentioned in nine studies. ConclusionHerbal therapy for macular hemorrhage in patients with pathological myopia could promote the absorption of macular hemorrhage, reduce central retinal thickness, it shows its advantages in overall therapeutic effects of treating macular hemorrhage in patients with pathological myopia, therapeutic methods are nourishing blood and tonifying essence, activating blood and moving Qi. The effects of herbal intervention are superior to these of only Western medicine or surgery, while more high-quality experiments are needed to improve the research level.

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备注/Memo

备注/Memo:
王健全(1993—),男,博士学位。研究方向:眼科疾病的中西医结合诊治。国家中医药管理局中医眼科专病(儿童青少年近视防控)循证能力提升建设;中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者;北京市石景山区亢泽峰名医传承工作室项目;深圳市医疗卫生三名工程(SZSM201812090)。
更新日期/Last Update: 2022-01-15