[1]李晓梅,吴晓兵,于文姣.补虚活血通络方联合噻托溴铵治疗COPD迁延期临床疗效及其作用机制[J].西部中医药,2022,35(01):112-115.[doi:10.12174/j.issn.2096-9600.2022.01.27]
　LI Xiaomei,WU Xiaobing,YU Wenjiao.Clinical Effects of Deficiency-tonifying Blood-activating Collateral-dredging Prescription and Tiotropium Bromide in the Treatment of COPD at Middle Later Stage and Its Mechanism[J].Western Journal of Traditional Chinese Medicine,2022,35(01):112-115.[doi:10.12174/j.issn.2096-9600.2022.01.27]
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补虚活血通络方联合噻托溴铵治疗COPD迁延期临床疗效及其作用机制
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年01期
页码:
112-115
栏目:
衷中参西
出版日期:
2022-01-15

文章信息/Info

Title:
Clinical Effects of Deficiency-tonifying Blood-activating Collateral-dredging Prescription and Tiotropium Bromide in the Treatment of COPD at Middle Later Stage and Its Mechanism
作者:
李晓梅, 吴晓兵, 于文姣
辽宁中医药大学附属第二医院，辽宁 沈阳 110034
Author(s):
LI Xiaomei, WU Xiaobing, YU Wenjiao
The Second Affiliated Hospital to Liaoning University of Traditional Chinese Medicine, Shenyang 110034, China
关键词:
慢性阻塞性肺疾病; LTB4; IL-8; 补虚活血通络方; 噻托溴铵
Keywords:
COPD; LTB-4; IL-8; deficiency-tonifying blood-activating collateral-dredging prescription; tiotropium bromide
分类号:
R562.2
DOI:
10.12174/j.issn.2096-9600.2022.01.27
摘要:
目的探讨补虚活血通络方联合噻托溴铵治疗慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）迁延期的临床疗效及对血清白三烯B4（leukotriene B4，LTB4）、白细胞介素8（interleukin-8，IL-8）水平的影响。 方法将85例COPD迁延期患者随机分为两组，因随访失败，最终联合组和单一组各40例，单一组行噻托溴铵粉吸入剂治疗，必要时予机械通气，联合组在单一组基础上予补虚活血通络方，观察治疗前后两组患者血清LTB4与IL-8水平、肺功能检测、嗜酸性粒细胞（eosinophilic granulocyte，EOS）计数及圣乔治呼吸问卷（St George’s Respiratory Questionnaire，SGRQ）与6 min步行距离实验（6minute walking distance，6MWD）问卷评分，并观察疗效。 结果两组治疗后血清LTB4与IL-8水平、SGRQ与6MWD问卷评分、用力肺活量（forced expiratory volume，FEV）、1秒用力呼气容积（forced expiratory volume in one second，FEV1）、呼气峰流量（peak expiratory flow，PEF）及临床疗效联合组优于单一组（P＜0.05）。 结论补虚活血通络方联合噻托溴铵治疗COPD迁延期效果优于单纯噻托溴铵治疗，能减轻患者症状，改善相关指标。
Abstract:
ObjectiveTo investigate clinical effects of deficiency-tonifying blood-activating collateral-dredging prescription and tiotropium bromide in the treatment of COPD at middle later stage and its influence on the levels of serum LTB4 and IL-8. MethodsAll 85 patients were randmized into two groups, the combination group and the single group with 40 cases in each group consequently due to follow-up failure, the single group was treated by tiotropium bromide powder inhalant, mechanical ventiilation if necessary, the combination group took deficiency-tonifying blood-activating collateral-dredging prescription based on the therapy the single group accepted, to observe the levels of serum LTB4/IL-8, the detection of pulmonary function, EOS count and the scores of SGRQ， 6MWD questionaire before and after treating, to assess clinical effects. ResultsAfter treating, the levels of serum LTB-4/IL-8, the scores of SGRQ， 6MWD questionaire, FEV, FEV1, PEF and clinical effects of the combination group were superior to these of the single group (P<0.05). ConclusionDeficiency-tonifying blood-activating collateral-dredging prescription and tiotropium bromide in the treatment of COPD at middle later stage is superior to single Western medicine, it could relieve the symptoms and improve the related indexes.

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备注/Memo

备注/Memo:
李晓梅（1980—），女，副主任医师。研究方向：呼吸系统疾病的中医药防治。辽宁省科学技术计划项目（2015225015）。
更新日期/Last Update: 2022-01-15