[1]陈艳,孙连庆,胡粒山.六君子汤加减对晚期非小细胞肺癌GP方案肺脾气虚型患者的作用机制研究[J].西部中医药,2022,35(01):119-123.[doi:10.12174/j.issn.2096-9600.2022.01.29]
 CHEN Yan,SUN Lianqing,HU Lishan.Study on the Mechanism of Modified Liujunzi Decoction in the Treatment for Advanced Non-small Cell Lung Cancer Patients of Lung-spleen Qi Deficiency Pattern Undergoing GP Regimen[J].Western Journal of Traditional Chinese Medicine,2022,35(01):119-123.[doi:10.12174/j.issn.2096-9600.2022.01.29]
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六君子汤加减对晚期非小细胞肺癌GP方案肺脾气虚型患者的作用机制研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年01期
页码:
119-123
栏目:
衷中参西
出版日期:
2022-01-15

文章信息/Info

Title:
Study on the Mechanism of Modified Liujunzi Decoction in the Treatment for Advanced Non-small Cell Lung Cancer Patients of Lung-spleen Qi Deficiency Pattern Undergoing GP Regimen
作者:
陈艳1 孙连庆2 胡粒山1
1.新疆生产建设兵团第九师医院,新疆 额敏 834601
2.西安交通大学第一附属医院
Author(s):
CHEN Yan1 SUN Lianqing2 HU Lishan1
1.The Ninth Division Hospital of Xinjiang Production and Construction Corps, Emin 834601, China
2.The First Affiliated Hospital of Xi'an Jiaotong University
关键词:
晚期非小细胞肺癌肿瘤转移肺脾气虚内皮生长因子前列腺素E免疫功能六君子汤GP方案
Keywords:
advanced NSCLCtumor metastasislung-spleen deficiencyendothelial growth factorPGEimmunitydecoctionGP regimen
分类号:
R734.2
DOI:
10.12174/j.issn.2096-9600.2022.01.29
摘要:
目的探讨六君子汤加减对晚期非小细胞肺癌GP方案患者(肺脾气虚型)肿瘤指标、免疫功能的影响。 方法将肺脾气虚型晚期非小细胞肺癌并行GP方案化疗患者98例应用随机数字表法分为两组各49例。对照组采用GP方案,21天为1个化疗周期,观察组在对照组基础上予六君子汤加减治疗,2个化疗周期后比较疗效。 结果治疗后观察组血清细胞角蛋白19片段21-1(cell keratin 19 fragment 21-1,CYFRA21-1)、糖类抗原125(carbohydrate antigen 125,CA125)、神经元特异性烯醇化酶(Neuron-specific enolase,NSE)、血清血管内皮生长因子(Vascular endothelial growth factor,VEGF)、基质金属蛋白酶9(Matrix metalloproteinase-9,MMP-9)、血清碱性成纤维细胞生长因子(basic fibroblast growth factor,bFGF)、前列腺素E2(prostaglandin E2,PGE2)等均低于对照组(P<0.05),治疗后观察组血清CD4+/CD8+、CD4+细胞等T淋巴亚群水平高于对照组,差异有统计学意义(P<0.05);总有效率观察组为61.22%(30/49),对照组为40.82%(20/49),差异有统计学意义(P<0.05);观察组肝肾功能损伤、胃肠道反应、骨髓抑制等不良反应发生率低于对照组(P<0.05)。 结论GP方案联合六君子汤加减可抑制肺脾气虚型晚期非小细胞肺癌患者血管新生,改善免疫功能,预防肿瘤转移,降低化疗不良反应发生率。
Abstract:
ObjectiveTo explore the influence of modified Liujunzi decoction on tumor indexes and immunity in advanced NSCLC patients of lung-spleen Qi deficiency pattern undergoing GP regimen. MethodsAll 98 patients were allocated to two groups using random number table method, with 49 cases in each group. The control group adopted GP regimen, and 21 days were one course of chemotherapy, the observation group took modified Liujunzi decoction based on GP regimen, to compare clinical effects after two courses of chemotherapy. ResultsAfter treating, the levels of CYFRA21-1, CA125, NSE,VEGF, MMP-9, bFGF and PGE2 of the observation group were lower than these of the control group, and the difference had statistical meaning (P<0.05); after treating, the levels of T lymphocyte subsets including CD4+/CD8+, CD4+ cells of the observation group were higher than these of the control group, and the difference showed statistical meaning (P<0.05); total effective rate of the observation group was 61.22% (30/49), higher than 40.82% (20/49) of the control group, and there was a significant difference (P<0.05); the observation group was lower than the control group in the incidence of adverse reactions including liver and kidney function injury, gastrointestinal response and bone marrow suppression (P<0.05). ConclusionGP regimen combined with modified Liujunzi decoction could inhibit the angiogenesis, improve the immunity, prevent tumor metastasis and reduce the incidence of chemotherapy-related adverse reaction.

相似文献/References:

[1]安书芬,申艳方,张亚密△.健脾益肾汤联合NP方案治疗晚期非小细胞肺癌临床观察[J].西部中医药,2016,29(03):79.
 AN Shufeng,SHEN Yanfang,ZHANG Yami.Clinical Observation on JianPi YiShen Tang Combined with NP Regimen in Treating Advanced Non-small Cell Lung Cancer[J].Western Journal of Traditional Chinese Medicine,2016,29(01):79.

备注/Memo

备注/Memo:
陈艳(1980—),女,副主任医师。研究方向:肿瘤疾病的中医药防治。新疆生产建设兵团第九师医院科技项目。
更新日期/Last Update: 2022-01-15