[1]许建英,茅国琴,张萍,等.清心滋肾汤治疗绝经综合征心肾不交证的临床研究[J].西部中医药,2022,35(02):91-95.[doi:10.12174/j.issn.2096-9600.2022.02.22]
 XU Jianying,MAO Guoqin,ZHANG Ping,et al.Clinical Study on Heart-clearing Kidney-nourishing Decoction in Treating Menopausal Syndrome of Heart-kidney Imbalance Pattern[J].Western Journal of Traditional Chinese Medicine,2022,35(02):91-95.[doi:10.12174/j.issn.2096-9600.2022.02.22]
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清心滋肾汤治疗绝经综合征心肾不交证的临床研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年02期
页码:
91-95
栏目:
临证经验
出版日期:
2022-02-15

文章信息/Info

Title:
Clinical Study on Heart-clearing Kidney-nourishing Decoction in Treating Menopausal Syndrome of Heart-kidney Imbalance Pattern
作者:
许建英1 茅国琴1 张萍2 陈云3
1.张家港市第六人民医院,江苏 张家港 215600
2.苏州大学附属张家港医院
3.江苏省中医院
Author(s):
XU Jianying1 MAO Guoqin1 ZHANG Ping2 CHEN Yun3
1.Sixth People's Hospital of Zhangjiagang, Zhangjiagang 215600, China
2.Zhangjiagang Affiliated Hospital to Soochow University
3.Jiangsu Province Hospital of TCM
关键词:
绝经综合征清心滋肾汤心肾不交证神经-内分泌
Keywords:
menopausal syndromeheart-clearing kidney-nourishing decoctionheart-kidney imbalance patternneuro-endocrine
分类号:
R271.11+6
DOI:
10.12174/j.issn.2096-9600.2022.02.22
文献标志码:
B
摘要:
目的探讨清心滋肾汤治疗绝经综合征(menopausal syndrome,MPS)心肾不交证的临床疗效及对神经-内分泌的影响。 方法选取MPS患者104例,按随机数字表法分为对照组和观察组,每组52例。对照组给予中药安慰剂,观察组给予清心滋肾汤治疗。比较两组临床疗效,症状评分,Kupperman指数(Kupperman index,KI),生存质量量表(menopause-specific quality of life,MENQOL)评分,外周血中肿瘤转移抑制基因亲吻素1(kisspeptins-1,Kiss-1)、内源性受体G蛋白偶联受体54(G protein-coupled receptor 54,GPR54)、神经激肽B(neurokinin B,NKB)、强啡肽(dynorphin,DYN)mRNA水平,血清促性腺激素释放激素(gonadotropin releasing hormone,GnRH)、雌二醇(estradiol,E2)、卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)水平。 结果治疗后,观察组临床疗效总有效率[98.08%(51/52)]高于对照组[84.62%(44/52)](P<0.01)。观察组症状评分,KI、MENQOL总分均低于对照组(P<0.01)。观察组外周血中Kiss-1、GPR54、NKB、DYN mRNA及血清GnRH、FSH、LH水平低于对照组,E2高于对照组,差异有统计学意义(P<0.01)。 结论清心滋肾汤治疗MPS心肾不交证可改善患者临床症状和生活质量,提高疗效,调节神经-内分泌的作用可能是其疗效途径之一。
Abstract:
ObjectiveTo investigate curative efficacy of heart-clearing kidney-nourishing decoction in the treatment of MPS of heart-kidney imbalance pattern and its regulatory effect on neuro-endocrine. MethodsA total of 104 MPS cases were selected and divided into the control group and the observation group with 52 cases in each group in light of random number method. The control group was given herbal placebo and the observation group was treated with heart-clearing kidney-nourishing decoction. To compare curative effects, symptom scales, KI, MENQOL scores, the levels of Kiss-1, GPR54, NKB, DYN mRNA in peripheral blood, the levels of GnRH, E2, FSH and LH between both groups. ResultsAfter treating, total effective rate of the observation group was 98.08%(51/52), higher than 84.62% (44/52) of the control group (P<0.01). The observation group was lower than the control group in symptom scales, KI and MENQOL scores (P<0.01). The levels of Kiss-1, GPR54, NKB and DYNmRNA in peripheral blood, the levels of serum GnRH, FSH and LH of the observation group were lower than these of the control group, the levels of E2 higher than these of the control group, and the difference was statistically significant (P<0.01). ConclusionHeart-clearing kidney-nourishing decoction in the treatment of MPS of heart-kidney imbalance pattern could help improve the symptoms and quality of life, raise clinical effects, and the effects of regulating neuro-endocrine might be one of therapeutic approaches.

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[1]刘迎萍,柳树英△,张丽君.知柏地黄汤加味治疗绝经综合征46例[J].西部中医药,2012,25(11):95.
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[2]李江慧,曹保利.风引汤治疗肝阳上亢型绝经综合征47例[J].西部中医药,2014,27(12):68.
[3]刘海红,卢苏.清心滋肾汤联合辛伐他汀治疗绝经期综合征临床观察[J].西部中医药,2021,34(02):100.[doi:10.12174/j.issn.2096-9600.2021.02.27]
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备注/Memo

备注/Memo:
许建英(1988—),女,主任医师。研究方向:妇产科疾病的临床诊治。江苏省卫生计生委2016年度青年科研课题(Q201602)。
更新日期/Last Update: 2022-06-22