[1]潘丹萍,韩雪,孙凤平.补中助长颗粒联合生活方式干预脾虚型特发性矮身材疗效观察[J].西部中医药,2022,35(03):96-99.[doi:10.12174/j.issn.2096-9600.2022.03.21]
　PAN Danping,HAN Xue,SUN Fengping.Clinical Observation on Buzhong Zhuzhang Granules and Lifestyle Intervention for Idiopathic Short Stature of Spleen Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2022,35(03):96-99.[doi:10.12174/j.issn.2096-9600.2022.03.21]
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补中助长颗粒联合生活方式干预脾虚型特发性矮身材疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年03期
页码:
96-99
栏目:
出版日期:
2022-03-15

文章信息/Info

Title:
Clinical Observation on Buzhong Zhuzhang Granules and Lifestyle Intervention for Idiopathic Short Stature of Spleen Deficiency Pattern
作者:
潘丹萍, 韩雪, 孙凤平
郑州大学附属儿童医院/河南省儿童医院/郑州儿童医院，河南 郑州 450053
Author(s):
PAN Danping, HAN Xue, SUN Fengping
Children’s Hospital Affiliated to Zhengzhou University/Henan Children’s Hospital/ Zhengzhou Children’s Hospital,Zhengzhou 450053, China
关键词:
特发性矮身材; 生活方式; 补中助长颗粒; 临床疗效
Keywords:
ISS; lifestyle; granules; clinical effects
分类号:
R584.2
DOI:
10.12174/j.issn.2096-9600.2022.03.21
文献标志码:
B
摘要:
目的观察补中助长颗粒联合生活方式干预脾虚型特发性矮身材（idiopathic short stature，ISS）的临床疗效，探讨其对GH-IGF-1轴的影响。 方法将脾虚型ISS患儿63例随机分为空白组（n=20）、观察组（n=22）、对照组（n=21），空白组给予生活方式干预，观察组在空白组基础上口服补中助长颗粒，对照组在空白组基础上口服赖氨肌醇维生素B12口服溶液。比较3组患儿治疗前及治疗6、12个月身高、体质量、骨龄（bone age，BA）与血清生长激素峰值（growth hormone peak，GHP）、胰岛素样生长因子1（insulin-like growth factor-1，IGF-1）水平。 结果治疗6个月，观察组IGF-1高于空白组、对照组，差异有统计学意义（P＜0.05）；治疗12个月，观察组身高、IGF-1高于空白组、对照组，观察组体质量高于空白组，对照组IGF-1高于空白组，差异有统计学意义（P＜0.05）；治疗后3组BA、GHP比较差异无统计学意义（P＞0.05）。 结论补中助长颗粒联合生活方式干预可能通过调节GH-IGF-1轴实现改善ISS患儿脾虚症状，促进身高、体质量增长，刺激IGF-1表达。
Abstract:
ObjectiveTo observe clinical effects of Buzhong Zhuzhang granules combined with lifestyle intervention in treating idiopathic short stature (ISS) of spleen deficiency pattern, and explore its influence on GH-IGF-1 axis. MethodsAll 63 cases of spleen deficiency pattern ISS were randomized into the blank group (n=20), the observation group (n=22) and the control group (n=21), the blank group was intervened with lifestyle, the observation group took Buzhong Zhuzhang granules based on the therapy the blank group received, and the control group was given lysine inositol vitamin B12 oral solution orally. To compare the height, body mass, bone age, and the levels of GHP and IGF-1 between three groups before treating, after six and 12 months of treatment. ResultsThe level of IGF-1 of the observation group was higher than that of the blank group and the control group six months after treating, and the difference had statistical meaning (P<0.05); after 12 months of treatment, the height and the level of IGF-1 of the observation group were higher than these of the blank group and the control group, body mass of the observation group was higher than that of the blank group, the level of IGF-1 of the control group was higher than that of the blank group, and the difference showed statistical meaning (P<0.05); the difference had no statistical meaning in the comparisons of BA and GHP between three groups after treating (P>0.05). ConclusionBuzhong Zhuzhang granules combined with lifestyle intervention could improve the symptoms of spleen deficiency in ISS, boost the increase of height and body mass, stimulate the expressions of IGF-1, which is realized possibly through adjusting GH-IGF-1 axis.

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备注/Memo

备注/Memo:
潘丹萍（1992—），女，硕士学位，医师。研究方向：儿科疾病的中医药治疗。河南省科技攻关项目（182102310395）；河南省中医药科学研究专项课题（2019ZY3012）；韩雪名中医学术经验研究工作室建设项目（zsmzy201810）。
更新日期/Last Update: 2022-06-24