[1]哈华兰,黄新梅,高红梅,等.黄葵胶囊联合尿毒清颗粒对慢性肾功能不全患者临床疗效及炎症因子的影响[J].西部中医药,2022,35(06):111-114.[doi:10.12174/j.issn.2096-9600.2022.06.27]
 HA Hualan,HUANG Xinmei,GAO Hongmei,et al.Clinical Effects of Huangkui Capsules and Niaoduqing Granules in Treating Chronic Renal Failure and Its Influence on Inflammatory Factors[J].Western Journal of Traditional Chinese Medicine,2022,35(06):111-114.[doi:10.12174/j.issn.2096-9600.2022.06.27]
点击复制

黄葵胶囊联合尿毒清颗粒对慢性肾功能不全患者临床疗效及炎症因子的影响
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年06期
页码:
111-114
栏目:
临证经验
出版日期:
2022-06-15

文章信息/Info

Title:
Clinical Effects of Huangkui Capsules and Niaoduqing Granules in Treating Chronic Renal Failure and Its Influence on Inflammatory Factors
作者:
哈华兰 黄新梅 高红梅 曹文琼
兰州市第一人民医院,甘肃 兰州 730050
Author(s):
HA Hualan HUANG Xinmei GAO Hongmei CAO Wenqiong
The First People′s Hospital of Lanzhou City, Lanzhou 730050, China
关键词:
肾功能衰竭慢性黄葵胶囊尿毒清颗粒肾功能生存质量临床疗效
Keywords:
renal failure chroniccapsulesgranulesrenal functionquality of lifeclinical effects
分类号:
R692.5
DOI:
10.12174/j.issn.2096-9600.2022.06.27
文献标志码:
B
摘要:
目的探讨黄葵胶囊联合尿毒清颗粒治疗慢性肾功能衰竭患者的临床疗效及对微炎症状态的影响。 方法将135例慢性肾功能衰竭患者随机分为黄葵胶囊治疗组(口服黄葵胶囊)、尿毒清颗粒(口服尿毒清颗粒)组和联合治疗组(口服黄葵胶囊加尿毒清颗粒),每组45例,连续治疗8个月。比较各组临床疗效、不良反应发生情况及肾功能指标[血尿素氮(blood urea nitrogen,BUN)、血肌酐(serum creatinine,Scr)]、24 h尿蛋白定量、超敏C反应蛋白(high-sensitivity C-reactive protein,hs-CRP)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)水平。 结果联合治疗组总有效率[93.33%(42/45)]高于黄葵胶囊组[73.33%(33/45)]及尿毒清颗粒组[84.44%(38/45)](P<0.05)。治疗后,黄葵胶囊组与尿毒清颗粒组比较,血清Scr、BUN、hs-CRP、TNF-α水平,差异无统计学意义(P>0.05);24 h尿蛋白定量水平明显下降(P<0.05)。治疗后,联合治疗组与其他两组比较,血清Scr、BUN、hs-CRP、TNF-α水平及24 h尿蛋白定量均明显下降(P<0.05)。各组在研究中均未发生明显不良反应。 结论黄葵胶囊联合尿毒清颗粒治疗慢性肾功能衰竭患者,能明显改善慢性肾功能不全患者体内微炎症状态,可促进肾功能的恢复,提高患者生存质量,临床疗效好,安全性高。
Abstract:
ObjectiveTo discuss clinical effects of Niaoduqing granules and Huangkui capsules in the treatment of chronic renal failure (CRF) and its influence on microinflammatory state. MethodsAll 135 CRF patients were randomized into Huangkui capsules group, Niaoduqing granules group and the combined treatment group, with 45 cases in each group. To compare clinical effects, the indexes of renal function [BUN, Scr], 24h quantitative urinary protein, hs-CRP, the levels of TNF-α and adverse reaction between three groups. ResultsTotal effective rate of the combined treatment group was [93.33%(42/45)], higher than [73.33%(33/45)] of Huangkui capsules group and [84.44%(38/45)] of Niaoduqing granules group (P<0.05). After treatment, the difference had no statistical meaning in the levels of Scr, BUN, hs-CRP and TNF-α between Huangkui capsules group and Niaoduqing granules group (P>0.05); the levels of 24h quantitative urinary protein lowered notably (P<0.05). After treatment, when the combined treatment group was compared with the other groups, the levels of Scr, BUN, hs-CRP, TNF-α and 24h quantitative urinary protein were significantly decreased (P<0.05). No adverse reaction occurred in three groups in the process of the study. ConclusionHuangkui capsules in combination with Niao-duqing granules in treating CRF patients could notably improve microinflammatory state in the patients with chronic renal insufficiency, promote the recovery of renal function, improve the quality of life with high clinical effects and safety.

相似文献/References:

[1]马军,郑月萍,严兴海,等.加味薏苡附子败酱散治疗寒湿血瘀型慢性前列腺炎38例临床研究[J].西部中医药,2012,25(12):7.
 MA Jun,ZHENG Yue-ping,YAN Xing-hai,et al.On Modified YiYi FuZi BaiJiangSan for 38 Cases of Chronic Prostatitis of Cold-dampness Blood Stasis Pattern[J].Western Journal of Traditional Chinese Medicine,2012,25(06):7.
[2]孙安兵,王三吉,金芃.麻杏甘石汤合瓜蒌薤白桂枝汤治疗老年慢性喘证122例临床观察[J].西部中医药,2012,25(12):71.
 SUN An-bing,WANG San-ji,JIN Peng.Clinical Observation on MaXing GanShiTang and GuaLou XieBai GuiZhiTang for 122 Cases of Senile Chronic Asthma[J].Western Journal of Traditional Chinese Medicine,2012,25(06):71.
[3]崔毅.益气活血汤治疗慢性盆腔炎64例临床观察[J].西部中医药,2012,25(12):75.
 CUI Yi.Clinical Observation on YiQi HuoXueTang and Activating Blood Decoction in Treating 64 Cases of Chronic Pelvic Inflammatory Disease[J].Western Journal of Traditional Chinese Medicine,2012,25(06):75.
[4]应语,姚昶△,卞卫和,等.生肌玉红膏干预下肢慢性溃疡创面炎症反应的临床研究*[J].西部中医药,2013,26(02):7.
 YING Yu,YAO Chang,BIAN Weihe,et al.Clinical Study on Intervention of ShengJi YuHongGao to Wound Inflammatory Reaction of Leg with Chronic Ulcer[J].Western Journal of Traditional Chinese Medicine,2013,26(06):7.
[5]樊斗霜.枳实消痞丸(汤)合丹参饮加减治疗慢性萎缩性胃炎32例[J].西部中医药,2013,26(02):72.
 FAN Doushuang.Modified ZhiShi XiaoPiWan(Prescription) and DanShenYin in Treating 32 Cases of Chronic Atrophic Gastritis[J].Western Journal of Traditional Chinese Medicine,2013,26(06):72.
[6]关亚珍,指导:张洪涛.矩阵针灸治疗脾虚型慢性腹泻 30 例临床观察[J].西部中医药,2013,26(03):62.
 GUAN Yazhen Director: ZHANG Hongtao.Matrix Acupuncture in Treating 30 Cases of Chronic Diarrhea of Spleen Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2013,26(06):62.
[7]尤海鹰.制萎煎治疗脾胃虚弱型慢性萎缩性胃炎40例[J].西部中医药,2013,26(03):84.
 YOU Haiying.ZhiWeiJian in Treating 40 Cases of Chronic Atrophic Gastritis of Spleen-stomach Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2013,26(06):84.
[8]张建平,刘洁,赵志亮.针灸治疗慢性前列腺炎25例疗效观察[J].西部中医药,2013,26(03):111.
 ZHANG Jianping,LIU Jie,ZHAO Zhiliang.Observation on Acupuncture in Treating 25 Cases of Chronic Prostatitis[J].Western Journal of Traditional Chinese Medicine,2013,26(06):111.
[9]孙国荣,景克荣,权亚喜.生脉注射液对慢性心衰患者心功能及其心率变异性的影响[J].西部中医药,2013,26(04):68.
 SUN Guorong,JING Kerong,QUAN Yaxi.The Influence of ShengMai Injection on Heart Function and Heart Rate Variability of Patients with Chronic Heart Failure[J].Western Journal of Traditional Chinese Medicine,2013,26(06):68.
[10]陈强,王进吉,王亨飞,等.小针刀治疗慢性扁桃体炎43例[J].西部中医药,2013,26(04):71.
 CHEN Qiang,WANG Jingji,WANG Hengfei,et al.Treating 43 Cases of Chronic Tonsillitis with Small Needle-knife[J].Western Journal of Traditional Chinese Medicine,2013,26(06):71.
[11]杜雪飞,李桂珍,黄志霞.护理干预对瘙痒型慢性肾脏疾病中药皮肤透析患者的效果评价[J].西部中医药,2012,25(08):101.
 DU Xue-fei,LI Gui-zhen,HUANG Zhi-xia.Evaluation of Nursing Intervention for Patients with Pruritic Chronic Kidney Disease Undergoing Herbal Skin Dialysis[J].Western Journal of Traditional Chinese Medicine,2012,25(06):101.
[12]张宏,王旭昀,刘美奇,等.国医大师吕仁和教授治疗慢性肾功能衰竭经验总结[J].西部中医药,2020,33(02):37.[doi:10.12174/j.issn.1004-6852.2020.02.10]
 ZHANG Hong,WANG Xuyun,LIU Meiqi,et al.National Medicine Master Professor Lyu Renhe′s Experience in Treating Chronic Renal Failure[J].Western Journal of Traditional Chinese Medicine,2020,33(06):37.[doi:10.12174/j.issn.1004-6852.2020.02.10]

备注/Memo

备注/Memo:
哈华兰(1978—),女,硕士学位,副主任医师。研究方向:肾脏常见病的诊治。
更新日期/Last Update: 2022-06-24