[1]曹知勇,张青槐,庞宇舟.壮药青风藤总生物碱对类风湿性关节炎模型大鼠血清P-选择素、PECAM-1表达的影响[J].西部中医药,2022,35(08):23-25.[doi:10.12174/j.issn.2096-9600.2022.08.06]
 CAO Zhiyong,ZHANG Qinghuai,PANG Yuzhou.Influence of Zhuang Medicine Total Alkaloids of Qingfengteng on the Expressions of Serum P-selectin, PECAM-1 in Rat Models Suffering from Rheumatoid Arthritis[J].Western Journal of Traditional Chinese Medicine,2022,35(08):23-25.[doi:10.12174/j.issn.2096-9600.2022.08.06]
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壮药青风藤总生物碱对类风湿性关节炎模型大鼠血清P-选择素、PECAM-1表达的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年08期
页码:
23-25
栏目:
药理研究
出版日期:
2022-08-15

文章信息/Info

Title:
Influence of Zhuang Medicine Total Alkaloids of Qingfengteng on the Expressions of Serum P-selectin, PECAM-1 in Rat Models Suffering from Rheumatoid Arthritis
作者:
曹知勇12 张青槐1 庞宇舟1
1.广西壮瑶药工程技术研究中心,广西 南宁 530200
2.湖北民族大学医学部
Author(s):
CAO Zhiyong12 ZHANG Qinghuai1 PANG Yuzhou1
1.Guangxi Zhuang Yao Medicine Engineering Technology Research Center, Nanning 530200, China
2.Medical School, Hubei Minzu University
关键词:
关节炎类风湿性壮药青风藤P-选择素PECAM-1动物实验SD大鼠
Keywords:
arthritis rheumatoidmedicineP-selectinPECAM-1animal experimentSD rats
分类号:
R593.22
DOI:
10.12174/j.issn.2096-9600.2022.08.06
摘要:
目的探究壮药青风藤总生物碱对类风湿关节炎模型大鼠血清P-选择素(P-selectin,CD62P)、血小板内皮细胞黏附因子(platelet endothelial cell adhesion molecule 1,PECAM-1)表达的影响。 方法选用40只SD大鼠,分为空白组,模型组,青风藤低、中、高剂量组,每组8只。除空白组外,其余各组均使用Ⅱ型胶原酶诱导关节炎模型。各给药组给予对应药物灌胃,给药4周后收集大鼠血清,采用ELISA法检测血清中P-选择素、PECAM-1的表达。 结果造模后,造模组大鼠关节肿胀明显,血清中P-选择素、PECAM-1表达明显高于空白组(P<0.05)。给药后,与模型组比较,青风藤各剂量组大鼠血清中P-选择素、PECAM-1表达均明显降低(P<0.05),且青风藤高剂量组明显低于青风藤低剂量组(P<0.05)。 结论壮药青风藤总生物碱能降低模型大鼠血清中P-选择素及PECAM-1的表达,从而减轻类风湿关节炎症状。
Abstract:
ObjectiveTo survey the effects of Zhuang medicine total alkaloids of Qingfengteng (sinomenii caulis) on the expressions of serum P-selectin (CD62P) and PECAM-1 in rats with rheumatoid arthritis (RA). MethodsForty SD rats were chosen and randomized into the blank group, the model group, low, moderate and high doses groups of Qingfengteng, eight rats in each group. Except the blank group, the rats in other groups were prepared into arthritis models by using type Ⅱ collagenase. All the medication administration groups were drenched with the corresponding medicine, after medicating for four weeks and collecting the serum of the rats, ELISA method was used to detect the expressions of CD62P and PECAM-1 in the serum. ResultsAfter modeling, joint swelling of the rats in the modeling group was remarkable, and the expressions of P-selectin and PECAM-1 in the serum were more apparent than these of the blank group (P<0.05). After medication, compared with the model group, the expressions of P-selectin and PECAM-1 in different doses groups of Qingfengteng were decreased notably (P<0.05), and high dose group of Qingfengteng was obviously lower than low dose group of Qingfengteng (P<0.05). ConclusionZhuang medicine total alkaloids of Qingfengteng could lower the expressions of P-selectin and PECAM-1 in the serum of rat models, consequently to relieve the symptoms of rheumatoid arthritis.

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备注/Memo

备注/Memo:
曹知勇(1994—),男,硕士学位,在读博士研究生。研究方向:内科疾病的研究。国家自然科学基金(81973976);广西一流学科建设项目(桂教科研[2018]12)。
更新日期/Last Update: 2022-08-15