[1]朱喜春,徐继军,朱旭江,等.阿胶益寿口服液中陈皮的质量控制方法研究[J].西部中医药,2022,35(08):35-39.[doi:10.12174/j.issn.2096-9600.2022.08.09]
 ZHU Xichun,XU Jijun,ZHU Xujiang,et al.Study on Quality Control Method of Chenpi in Ejiao Yishou Oral Liquid[J].Western Journal of Traditional Chinese Medicine,2022,35(08):35-39.[doi:10.12174/j.issn.2096-9600.2022.08.09]
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阿胶益寿口服液中陈皮的质量控制方法研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年08期
页码:
35-39
栏目:
质量分析
出版日期:
2022-08-15

文章信息/Info

Title:
Study on Quality Control Method of Chenpi in Ejiao Yishou Oral Liquid
作者:
朱喜春12 徐继军12 朱旭江12 陈乾兑3 姚世霞12 张明童12 李成明4 李子彬12
1.甘肃省药品检验研究院,甘肃 兰州 730070
2.国家药品监督管理局中药材 及饮片质量控制重点实验室
3.长春中医药大学
4.甘肃省中医院
Author(s):
ZHU Xichun12 XU Jijun12 ZHU Xujiang12 CHEN Qiandui3 YAO Shixia12 ZHANG Mingtong12 LI Chengming4 LI Zibin12
1.Gansu Provincial Drug Inspection Institute, Lanzhou 730070, China
2.State Drug Administration-Key Laboratory of Quality Control of Chinese Medicinal Materials and Decoction Pieces
3.Changchun University of Chinese Medicine
4.Gansu Provincial Hospital of Traditional Chinese Medicine
关键词:
阿胶益寿口服液薄层色谱法高效液相色谱法陈皮橙皮苷
Keywords:
oral liquidTLCHPLChesperidin
分类号:
R283
DOI:
10.12174/j.issn.2096-9600.2022.08.09
摘要:
目的建立阿胶益寿口服液中陈皮的质量控制方法。 方法采用薄层色谱法对制剂中陈皮进行薄层色谱鉴别;利用高效液相色谱法研究阿胶益寿口服液中橙皮苷的含量,用Agilent-C18(250 mm×4.6 mm,5 μm) 色谱柱,以甲醇-0.2%磷酸(含0.1%的三乙胺)(35∶65)为流动相,流速1.0 mL/min,测量波长283 nm,进样量为10 μL。 结果陈皮薄层色谱斑点清晰,分离效果好,阴性无干扰,操作简便。回归方程为y=2028574.4357x+36488.8934,r2=0.9996,表明橙皮苷在0.0255~1.629 μg范围内线性良好,平均加样回收率为100.25%,RSD值为0.80%。 结论本研究建立的方法简便、可靠、重现性好,可作为阿胶益寿口服液中陈皮的质量控制方法。
Abstract:
ObjectiveTo establish the quality control method of Chenpi (Citri Reticulatae pericarpium) in Ejiao Yishou oral liquid. MethodsTLC was used to identify Chenpi in the preparation; HPLC was utilized to investigate the contents of hesperidin in Ejiao Yishou oral liquid, Agilent-C18 (250 mm×4.6 mm, 5 μm) chromatographic column was used, methanol-0.2% phosphoric acid (containing 0.1% triethylamine) (35:65) were chosen as mobile phase, flow rate 1.0 mL/min, detection wavelength was 283nm, and sample size was 10 μL. ResultsTLC of Chenpi has clear spots, good separation effects, no interference and simple operation. The regression equation is y=2028574.4357x+36488.8934, r2=0.9996, which indicated that hesperidin has the good linearity between 0.0255 and 1.629 μg, average recovery rate was 100.25%, RSD value was 0.80%. ConclusionThe approach established in the study, simple and convenient, reliable and reproducible, could be taken as the quality control method of Chenpi in Ejiao Yishou oral liquid.

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备注/Memo

备注/Memo:
朱喜春(1963—),男,副主任药师。研究方向:药品药效学、毒理学及实验动物模型研究。国家药典委员会2018年度国家药品标准提高工作项目(2018Z031);兰州市中药配方颗粒研究推广实训基地项目(2019-1-127);甘肃省药品产业技术扶持项目(2019KF004)。
更新日期/Last Update: 2022-08-15