[1]朱喜春,徐继军,朱旭江,等.阿胶益寿口服液中陈皮的质量控制方法研究[J].西部中医药,2022,35(08):35-39.[doi:10.12174/j.issn.2096-9600.2022.08.09]
　ZHU Xichun,XU Jijun,ZHU Xujiang,et al.Study on Quality Control Method of Chenpi in Ejiao Yishou Oral Liquid[J].Western Journal of Traditional Chinese Medicine,2022,35(08):35-39.[doi:10.12174/j.issn.2096-9600.2022.08.09]
点击复制

阿胶益寿口服液中陈皮的质量控制方法研究
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年08期
页码:
35-39
栏目:
质量分析
出版日期:
2022-08-15

文章信息/Info

Title:
Study on Quality Control Method of Chenpi in Ejiao Yishou Oral Liquid
作者:
朱喜春1,2, 徐继军1,2, 朱旭江1,2, 陈乾兑3, 姚世霞1,2, 张明童1,2, 李成明4, 李子彬1,2
1.甘肃省药品检验研究院，甘肃 兰州 730070
2.国家药品监督管理局中药材 及饮片质量控制重点实验室
3.长春中医药大学
4.甘肃省中医院
Author(s):
ZHU Xichun1,2, XU Jijun1,2, ZHU Xujiang1,2, CHEN Qiandui3, YAO Shixia1,2, ZHANG Mingtong1,2, LI Chengming4, LI Zibin1,2
1.Gansu Provincial Drug Inspection Institute, Lanzhou 730070, China
2.State Drug Administration-Key Laboratory of Quality Control of Chinese Medicinal Materials and Decoction Pieces
3.Changchun University of Chinese Medicine
4.Gansu Provincial Hospital of Traditional Chinese Medicine
关键词:
阿胶益寿口服液; 薄层色谱法; 高效液相色谱法; 陈皮; 橙皮苷
Keywords:
oral liquid; TLC; HPLC; hesperidin
分类号:
R283
DOI:
10.12174/j.issn.2096-9600.2022.08.09
摘要:
目的建立阿胶益寿口服液中陈皮的质量控制方法。 方法采用薄层色谱法对制剂中陈皮进行薄层色谱鉴别；利用高效液相色谱法研究阿胶益寿口服液中橙皮苷的含量，用Agilent-C18（250 mm×4.6 mm，5 μm） 色谱柱，以甲醇-0.2%磷酸（含0.1%的三乙胺）（35∶65）为流动相，流速1.0 mL/min，测量波长283 nm，进样量为10 μL。 结果陈皮薄层色谱斑点清晰，分离效果好，阴性无干扰，操作简便。回归方程为y=2028574.4357x+36488.8934，r2=0.9996，表明橙皮苷在0.0255～1.629 μg范围内线性良好，平均加样回收率为100.25%，RSD值为0.80%。 结论本研究建立的方法简便、可靠、重现性好，可作为阿胶益寿口服液中陈皮的质量控制方法。
Abstract:
ObjectiveTo establish the quality control method of Chenpi (Citri Reticulatae pericarpium) in Ejiao Yishou oral liquid. MethodsTLC was used to identify Chenpi in the preparation; HPLC was utilized to investigate the contents of hesperidin in Ejiao Yishou oral liquid, Agilent-C18 (250 mm×4.6 mm, 5 μm) chromatographic column was used, methanol-0.2% phosphoric acid (containing 0.1% triethylamine) (35:65) were chosen as mobile phase, flow rate 1.0 mL/min, detection wavelength was 283nm, and sample size was 10 μL. ResultsTLC of Chenpi has clear spots, good separation effects, no interference and simple operation. The regression equation is y=2028574.4357x+36488.8934, r2=0.9996, which indicated that hesperidin has the good linearity between 0.0255 and 1.629 μg, average recovery rate was 100.25%, RSD value was 0.80%. ConclusionThe approach established in the study, simple and convenient, reliable and reproducible, could be taken as the quality control method of Chenpi in Ejiao Yishou oral liquid.

相似文献/References:

[1]张涛,景明△.归芪通便颗粒的质量标准研究*[J].西部中医药,2013,26(03):31.
　ZHANG Tao,JING Ming,Study on Quality Standard of GuiQi TongBian Granules[J].Western Journal of Traditional Chinese Medicine,2013,26(08):31.
[2]戴晓雁,王玉洁,魏学兵.升血颗粒质量标准的研究[J].西部中医药,2013,26(09):31.
　DAI Xiaoyan,WANG Yujie,WEI Xuebing.Study on Quality Standard of ShengXue Granules[J].Western Journal of Traditional Chinese Medicine,2013,26(08):31.
[3]何静,高军,安晔.地补更年安颗粒质量标准研究[J].西部中医药,2014,27(09):24.
[4]戴晓雁,王玉洁,魏学兵.升血颗粒质量标准研究[J].西部中医药,2014,27(01):31.
　DAI Xiaoyan,WANG Yujie,WEI Xuebing.Study on Quality Standard of ShengXue Granules[J].Western Journal of Traditional Chinese Medicine,2014,27(08):31.
[5]黄以蓉.消炎止痛膏质量标准新研究[J].西部中医药,2014,27(11):34.
[6]李军山,陈钟,张肖建,等.木贼配方颗粒质量标准研究[J].西部中医药,2017,30(03):25.
　LI Junshan,CHEN Zhong,ZHANG Xiaojian,et al.Study on Quality Standard of MuZei Dispensing Granules[J].Western Journal of Traditional Chinese Medicine,2017,30(08):25.
[7]韩忠耀,陆廷祥,张秋瑾,等.苗药水冬瓜根皮药材质量标准提升研究[J].西部中医药,2019,32(03):41.
　HAN Zhongyao,LU Tingxiang,ZHANG Qiujin,et al.Improvement of Quality Standard for Miao Medicine ShuiDongGua GenPi[J].Western Journal of Traditional Chinese Medicine,2019,32(08):41.
[8]邱泉,覃聪慧,黄秋燕,等.神农蛇药酒的质量标准研究[J].西部中医药,2019,32(06):21.
　QIU Quan,QIN Conghui,HUANG Qiuyan,et al.Quality Standard of ShenNong Snake Liquor[J].Western Journal of Traditional Chinese Medicine,2019,32(08):21.
[9]梁欣健,姜倩娥,王叶茗.乳疾清合剂的质量标准提高研究[J].西部中医药,2022,35(05):25.[doi:10.12174/j.issn.2096-9600.2022.05.06]
　LIANG Xinjian,JIANG Qian'e,WANG Yeming.Study on the Quality Standard Improvement of Rujiqing Mixture[J].Western Journal of Traditional Chinese Medicine,2022,35(08):25.[doi:10.12174/j.issn.2096-9600.2022.05.06]
[10]孙宇,贾智超,张娟,等.甘草查尔酮胶囊质量标准研究[J].西部中医药,2023,36(01):30.[doi:10.12174/j.issn.2096-9600.2023.01.07]
　SUN Yu,JIA Zhichao,ZHANG Juan,et al.Study on Quality Standard of Licorice Chalcone Capsules[J].Western Journal of Traditional Chinese Medicine,2023,36(08):30.[doi:10.12174/j.issn.2096-9600.2023.01.07]

备注/Memo

备注/Memo:
朱喜春（1963—），男，副主任药师。研究方向：药品药效学、毒理学及实验动物模型研究。国家药典委员会2018年度国家药品标准提高工作项目（2018Z031）；兰州市中药配方颗粒研究推广实训基地项目（2019-1-127）；甘肃省药品产业技术扶持项目（2019KF004）。
更新日期/Last Update: 2022-08-15