[1]程艳彬,朱清广,孔令军,等.p38MAPK信号通路与神经病理性疼痛的脊髓中枢敏化关系研究进展[J].西部中医药,2022,35(11):149-152.[doi:10.12174/j.issn.2096-9600.2022.11.31]
　CHENG Yanbin,ZHU Qingguang,KONG Lingjun,et al.Advances in the Relationship between p38MAPK Signaling Pathway and Central Sensitization Spinal Cord in Neuropathic Pain[J].Western Journal of Traditional Chinese Medicine,2022,35(11):149-152.[doi:10.12174/j.issn.2096-9600.2022.11.31]
点击复制

p38MAPK信号通路与神经病理性疼痛的脊髓中枢敏化关系研究进展
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年11期
页码:
149-152
栏目:
出版日期:
2022-11-15

文章信息/Info

Title:
Advances in the Relationship between p38MAPK Signaling Pathway and Central Sensitization Spinal Cord in Neuropathic Pain
作者:
程艳彬1,2, 朱清广1,2, 孔令军1,2, 房敏1,2,3
1.上海中医药大学附属岳阳中西医结合医院，上海 200437
2.上海市中医药研究院推拿研究所
3.上海中医药大学针灸推拿学院
Author(s):
CHENG Yanbin1,2, ZHU Qingguang1,2, KONG Lingjun1,2, FANG Min1,2,3
1.Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China
2.Institute of Massage, Shanghai Institute of Traditional Chinese Medicine
3.School of Acupuncture and Massage, Shanghai University of Traditional Chinese Medicine
关键词:
神经病理性疼痛; 脊髓中枢敏化; p38MAPK; 推拿
Keywords:
neuropathic pain; central sensitization of spinal cord; p38MAPK; massage
分类号:
R826
DOI:
10.12174/j.issn.2096-9600.2022.11.31
文献标志码:
A
摘要:
对P38丝裂原活化蛋白激酶（p38 mitogen activated protein kinase，p38MAPK）信号通路与神经病理性疼痛（neuropathic pain，NP）脊髓中枢敏化关系的研究进展进行综述，指出NP是一种外周或中枢神经系统受到损伤或发生病变引发的疼痛，其发生机制复杂，脊髓中枢敏化在此过程中的作用尤为重要；p38MAPK信号通路通过多种机制参与NP的脊髓中枢敏化的发生和维持；而推拿能够抑制因模型大鼠背根神经节（dorsal root ganglion，DRG）持续受压（chronic compression of DRG，CCD）导致的脊髓背角中枢敏化，因此推测p38/MAPK通路可能参与推拿对脊髓背角中枢敏化的抑制。
Abstract:
Neuropathic pain is a kind of pain induced by the injury or pathological changes of peripheral or central nervous system by summarizing the advances in the research on the relationship between p38MAPK and central sensitization of spinal cord in neuropathic pain, its pathogenic mechanism is complex, and central sensitization of spinal cord plays an important role in the process; p38MAPK signaling pathway participates in the occurrence and maintainance of central sensitization of spinal cord in neuropathic pain by many mechanisms; while massage inhibits central sensitization of spinal cord dorsal horn induced by sustained compression of rat dorsal root ganglion, therefore, we speculate that p38MAPK signaling pathway might participate in the inhibition of spinal cord dorsal horn central sensitization by massage.

相似文献/References:

[1]谢朝晖,李艳萍,安琪.曲马多联合电针对神经病理性疼痛大鼠行为学及脊髓相关细胞因子的影响*[J].西部中医药,2013,26(12):8.
　XIE Zhaohui,LI Yanping,AN Qi.Effects of Tramadol and Electronic Acupuncture on Behavioral Science and Spinal Cord Related Cytokines of Rats with Neuropathic Pain[J].Western Journal of Traditional Chinese Medicine,2013,26(11):8.
[2]王春爱,王迎斌,贾国龙,等.豆腐果苷对大鼠坐骨神经压迫性模型机械痛敏和热痛敏的影响[J].西部中医药,2012,25(07):20.
　WANG Chun-ai,WANG Ying-Bin,JIA Guo-long,et al.The Effect of Helicid on MWT and TWL in Rat Model with Chronic Compression Injury of Sciatic Nerve[J].Western Journal of Traditional Chinese Medicine,2012,25(11):20.
[3]林元杰,吴耀持△,郭晟.针灸治疗神经病理性疼痛的实验研究进展[J].西部中医药,2018,31(01):138.
　LIN Yuanjie,WU Yaochi,GUO Sheng.Research Progress of the Experiments of Acupuncture in Treating Neuropathic Pain[J].Western Journal of Traditional Chinese Medicine,2018,31(11):138.
[4]谢圆,谭萍.时间护理在慢性神经病理性疼痛中的应用价值[J].西部中医药,2018,31(07):116.
　XIE Yuan,TAN Ping.The Values of Time Nursing Applied to Chronic Neuropathic Pain[J].Western Journal of Traditional Chinese Medicine,2018,31(11):116.

备注/Memo

备注/Memo:
程艳彬（1986—），男，博士学位，主治医师。研究方向：推拿镇痛机制的研究。国家重大疑难疾病中西医临床协作试点建设项目［ZY（2018-2020）-FWTX-2005］；国家自然科学基金（81973973，82004493）；中医药传承与创新“百千万”人才工程（岐黄工程）岐黄学者，上海市进一步加快中医药事业发展三年行动计划（ZY（2018-2020）-CCCX-2004-02）；中华中医药学会青年托举人才项目（QNRC2-A01）；中医学“高峰高原学科”高水平创新团队（30304114316）；上海市卫生
更新日期/Last Update: 2022-11-15