[1]陈静,陈炜,唐秀松,等.基于网络药理学探讨人参治疗痴呆的作用机制[J].西部中医药,2022,35(12):50-55.[doi:10.12174/j.issn.2096-9600.2022.12.11]
　CHEN Jing,CHEN Wei,TANG Xiusong,et al.The Mechanism of Ginseng in the Treatment of Dementia by Using Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2022,35(12):50-55.[doi:10.12174/j.issn.2096-9600.2022.12.11]
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基于网络药理学探讨人参治疗痴呆的作用机制
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年12期
页码:
50-55
栏目:
出版日期:
2022-12-15

文章信息/Info

Title:
The Mechanism of Ginseng in the Treatment of Dementia by Using Network Pharmacology
作者:
陈静1, 陈炜2, 唐秀松1, 劳祎林1, 伍媛1, 吴林1
1.广西中医药大学，广西 南宁 530001
2.广西中医药大学第一附属医院
Author(s):
CHEN Jing1, CHEN Wei2, TANG Xiusong1, LAO Yilin1, WU Yuan1, WU Lin1
1.Guangxi University of Chinese Medicine, Nanning 530001, China
2.The First Affiliated Hospital of Guangxi University of Chinese Medicine
关键词:
痴呆; 人参; 网络药理学; 作用机制; 靶点; 通路
Keywords:
dementia; ginseng; network pharmacology; mechanism; targets; pathway
分类号:
R285
DOI:
10.12174/j.issn.2096-9600.2022.12.11
文献标志码:
A
摘要:
目的基于网络药理学探讨人参抗痴呆的作用机制。 方法采用中药系统药理学数据库与分析平台（traditional Chinese medicine systems pharmacology database and analysis platform，TCMSP）检索中药有效成分和相关靶点，利用GeneCards和OMIM数据库检索痴呆的基因靶点，构建蛋白互作网络（protein-protein interaction networks，PPI），进行GO功能富集分析及KEGG通路富集分析，构建可视化的信号通路。 结果从人参中筛选出22个有效成分，76个痴呆疾病作用靶点，112条GO生物学过程，127条KEGG通路。人参抗痴呆的核心基因主要有AKT1、CASP3、JUN、MAPK8、PTGS2、IL1B、PPARG等，这些基因可通过影响肽结合、酰胺结合、G蛋白偶联胺受体活性等来调控痴呆的发生。KEGG通路主要包括刺激神经组织的中的交互通路、流体剪切应力与动脉粥样硬化通路、肿瘤坏死因子信号通路等。 结论人参可通过多成分、多靶点、多途径抗痴呆，为将来提取人参有效成分治疗痴呆病提供了理论基础。
Abstract:
ObjectiveTo discuss the mechanism of ginseng in the treatment of dementia on the foundation of network pharmacology. MethodsThe effective constituents and the relevant targets of herbs were searched by using TCMSP, the gene targets of dementia were retrieved by using GeneCards and OMIM databases, to build PPI, conduct GO function enrichment analysis and KEGG pathway enrichment analysis, and construct visual signaling pathway. ResultsAll 22 active ingredients were screened out from ginseng, involving 76 targets of dementia, 112 biological processes of GO, 127 KEGG pathways. Core genes of ginseng in improving dementia contained AKT1, CASP3, JUN, MAPK8, PTGS2, IL1B, and PPARG, and these genes adjusted the occurrence of dementia by affecting the activity of peptide binding, amide binding, G protein-coupled amine receptors. KEGG pathways mainly covered interaction pathway stimulating nervous tissue, fluid shear stress and atherosclerosis pathway, and tumor necrosis factor signaling pathway. ConclusionGinseng could improve dementia by many ingredients, targets and ways, and it could provide theoretical foundation for the extraction of the active ingredients from ginseng for dementia in the future.

相似文献/References:

[1]李纬才.人参大补元气系讹传[J].西部中医药,2013,26(07):34.
　LI Weicai.Misrepresentation of Ginseng Greatly Tonifying the Original Qi[J].Western Journal of Traditional Chinese Medicine,2013,26(12):34.
[2]张雷鸣,任伟超,刘秀波,等.药用植物人参内生菌研究*[J].西部中医药,2014,27(05):129.
　ZHANG Leiming,REN Weichao,LIU Xiubo,et al.Research on Endophytes of Medicinal Plant Ginseng[J].Western Journal of Traditional Chinese Medicine,2014,27(12):129.
[3]丁玉梅,金建宁,张小静.血管性痴呆的中医证候特点研究[J].西部中医药,2019,32(06):54.
　DING Yumei,JIN Jianning,ZHANG Xiaojing.The Characteristics of TCM Syndromes of Vascular Dementia[J].Western Journal of Traditional Chinese Medicine,2019,32(12):54.

备注/Memo

备注/Memo:
陈静（1993—），女，在读硕士研究生。研究方向：脑血管病、帕金森病的研究及中医药防治。国家自然科学基金（81760846）；广西自然科学基金重点项目（2018GXNSFDA050018）；广西中医药大学一流学科开放课题（2019XK018）；广西中医药大学岐黄工程高层次人才团队培育项目（030030001-04B1804803-500101）；广西中医药大学第一附属医院学术团队（院字2018（146）号）。
更新日期/Last Update: 2022-12-15