[1]臧静愉,金艳涛,李鹏宇,等.基于文献计量学分析基因组学在中医证候领域的研究现状[J].西部中医药,2023,36(04):58-62.[doi:10.12174/j.issn.2096-9600.2023.04.14]
　ZANG Jingyu,JIN Yantao,LI Pengyu,et al.Research Status of Genomics in the Field of TCM Syndromes Based on Bibliometric Analysis[J].Western Journal of Traditional Chinese Medicine,2023,36(04):58-62.[doi:10.12174/j.issn.2096-9600.2023.04.14]
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基于文献计量学分析基因组学在中医证候领域的研究现状
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年04期
页码:
58-62
栏目:
出版日期:
2023-04-15

文章信息/Info

Title:
Research Status of Genomics in the Field of TCM Syndromes Based on Bibliometric Analysis
作者:
臧静愉1, 金艳涛2, 李鹏宇2, 杨俊1, 裴金燕1, 郭会军2
1.河南中医药大学，河南 郑州 450003
2.河南中医药大学第一附属医院艾研中心,河南 郑州 450003
Author(s):
ZANG Jingyu1, JIN Yantao2, LI Pengyu2, YANG Jun1, PEI Jinyan1, GUO Huijun2
1.Henan University of Chinese Medicine, Zhengzhou 450003, China
2.AIDS Research Center, The First Affiliated Hospital of Henan University of CM, Zhengzhou 450003, China
关键词:
基因组学; 中医; 证候; 文献计量学; 评价研究
Keywords:
genomics; traditional Chinese medicine; syndromes; bibliometrics; evaluation research
分类号:
R255
DOI:
10.12174/j.issn.2096-9600.2023.04.14
文献标志码:
A
摘要:
目的分析基因组学在中医领域的研究现状，以期为科研人员的研究提供借鉴。 方法以中国知网、万方数据库、维普、中国生物医学文献数据库为资料来源，检索从建库至2019年12月底关于基因组学在中医证候研究中的应用文献，建立文献数据库，采用文献计量学及数据挖掘的方法，对其文献特征及研究趋势进行统计分析。 结果最终纳入333篇文献，共分布在118种期刊上，其中中文核心期刊16种，共115篇，约占总文献量的34.5%；基因组学技术共应用于9类病种系统（以消化系统、循环系统为主）；其中研究最多的证型为：肝肾阴虚证、气虚证、气阴两虚证、痰湿证及阴阳两虚证；检测样本以血液制品为主，其次是组织；基因检测技术主要为荧光定量PCR技术、聚合酶链反应-限制性片段长度多态性方法、基因芯片技术。 结论国内应用基因组学技术进行中医证候分型的研究还有所欠缺，未达到统一化、客观化及标准化，同时文献的质量也有待提高，缺乏创新性。应扩大研究范围、增加样本量，加强提高临床实验研究的质量，为今后该领域的研究提供有价值的文献信息。
Abstract:
ObjectiveTo analyze the current status of genomics research in the field of TCM, in order to provide the reference for scientific researchers' research. MethodsUsing CNKI, Wanfang, VIP and SinoMed as sources, the literature on the application of genomics in the study of TCM syndrome were searched from the establishment of the database to the end of December, 2019, to establish the literature database, bibliometrics and data mining were used to perform statistical analysis of literature characteristics and research trends. ResultsConsequently, 333 papers were included, and jointly distributed in 118 journals, among them, there were 16 Chinese core journals, aggregating 115 papers and approximately occupying 34.5% of all the literature; genomics was applied to nine types of disease systems (principally to the digestive system and the circulation system); among them, the patterns studied the most were: Yin deficiency of liver and kidney pattern, Qi deficiency pattern, Qi and Yin deficiency pattern, phlegm dampness pattern and Yin-Yang deficiency pattern; the samples basically were blood products, tissue the next; the technologies of genomics were fluorescence-based quantitative PCR technique, polymerase chain reaction-restriction fragment length polymorphism method, and Gene chip technology. ConclusionThere are still some deficiencies in domestic research on the application of genomics in the classifica-tion of TCM patterns, which has not reached the unification, objectification and standardization, meanwhile, the quality of the literature needs to be improved, lacking innovation. We should expand the score of research, increase the sample size, enhance the quality of clinical experimental research, so as to provide the valuable literature and information for future research in this field.

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备注/Memo

备注/Memo:
臧静愉（1993—），女，硕士学位，住院医师。研究方向：中医内科学及传染病学。黄贵华广西名中医传承工作室项目［桂卫中医发（2017）2号］；广西中医药大学2019年校级硕士研究生科研创新项目（xjyb088）。 国家“十三五”科技重大专项（2017ZX10205501，2017ZX10205502-003）；国家自然科学基金（81803953，81873187）。
更新日期/Last Update: 2023-04-15