[1]阿地力江·阿力甫,卡哈尔·吐尔逊,克力比努尔·阿布力米提,等.环丙沙星联合茯苓皮汤加减治疗结直肠癌术后感染临床观察[J].西部中医药,2023,36(04):101-104.[doi:10.12174/j.issn.2096-9600.2023.04.23]
 Adilijiang·alifu,Kahaer·Tuerxun,Kelibinuer·Abulimiti,et al.Clinical Observation on Ciprofloxacin Combined with Modified Fulingpi Decoction in the Treatment of Postoperative Infection for Colorectal Cancer[J].Western Journal of Traditional Chinese Medicine,2023,36(04):101-104.[doi:10.12174/j.issn.2096-9600.2023.04.23]
点击复制

环丙沙星联合茯苓皮汤加减治疗结直肠癌术后感染临床观察
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年04期
页码:
101-104
栏目:
出版日期:
2023-04-15

文章信息/Info

Title:
Clinical Observation on Ciprofloxacin Combined with Modified Fulingpi Decoction in the Treatment of Postoperative Infection for Colorectal Cancer
作者:
阿地力江·阿力甫, 卡哈尔·吐尔逊, 克力比努尔·阿布力米提, 阿布都艾尼·阿布都瓦依提
喀什地区第一人民医院,新疆 喀什 844000
Author(s):
Adilijiang·alifu , Kahaer·Tuerxun , Kelibinuer·Abulimiti , Abuduaini·Abuduwayiti
The First People's Hospital of Kashgar Prefecture, Kashgar 844000, China
关键词:
结直肠癌环丙沙星茯苓皮汤术后感染胃肠功能Th1/Th2C反应蛋白
Keywords:
colorectal cancerciprofloxacindecoctionpostoperative infectiongastrointestinal functionTh1/Th2CRP
分类号:
R735.3+5
DOI:
10.12174/j.issn.2096-9600.2023.04.23
文献标志码:
B
摘要:
目的观察环丙沙星联合茯苓皮汤加减治疗结直肠癌术后感染的临床疗效及对胃肠功能、Th1/Th2、C反应蛋白(c reactive protein ,CRP)水平的影响。 方法选取结直肠癌术后感染患者92例,依据简单随机数字表法分为观察组与对照组,每组46例。对照组以环丙沙星治疗,观察组在此基础上服用茯苓皮汤加减方,两组均治疗1周。统计两组治疗效果,胃肠功能恢复时间及住院时间,治疗前后Th1/Th2水平,血清炎性因子[降钙素原(procalcitonin,PCT)、CRP、肿瘤坏死因子α(tumor necrosis factor α,TNF-α)、白细胞介素6(interleukin-6,IL-6)]水平,免疫功能指标(CD3+、CD4+、CD4+/CD8+)水平,不良反应发生率。 结果观察组总有效率[97.83%(45/46)]、不良反应发生率[10.87%(5/46)]与对照组总有效率[93.47%(43/46)]及不良反应发生率[8.70%(4/46)]比较,差异均无统计学意义(P>0.05)。观察组肠鸣音恢复时间、肛门排气时间、首次排便时间、恢复全流饮食时间及住院时间短于对照组(P<0.05)。治疗后两组血清Th1、Th1/Th2、CD3+、CD4+、CD4+/CD8+水平较治疗前增高,血清Th2、PCT、CRP、TNF-α、IL-6水平较治疗前降低(P<0.05),且观察组上述指标改善程度优于对照组(P<0.05)。 结论以环丙沙星联合茯苓皮汤加减治疗结直肠癌术后感染效果显著,可促使胃肠功能恢复,提高整体疗效,可能与其能有效调节Th1/Th2、免疫功能及体内炎性反应程度具有一定关联性,且该联合治疗方案安全性具有保证。
Abstract:
ObjectiveTo observe clinical effects of ciprofloxacin and modified Fulingpi decoction in the treatment of postoperative infection for colorectal cancer, and its influence on gastrointestinal function, the levels of Th1/Th2 and CRP. MethodsAll 92 patients with postoperative infection for colorectal cancer were chosen, allocated to the observation group and the control group according to simple random number table method, with 46 cases in each group. The control group was treated by ciprofloxacin, and the observation group took modified Fulingpi decoction based on ciprofloxacin, both groups were treated for one week. To count therapeutic effects, the recovery time of gastrointestinal function, hospitalization time, the levels of Th1/Th2 before and after treatment, serum inflammatory factors [PCT, CRP, TNF-α, IL-6], the changes of immune function index (CD3+, CD4+, CD4+/CD8+), and the incidence of adverse reaction between both groups. ResultsThe difference had no statistical meaning when total effective rate [97.83%(45/46)] and the incidences of adverse reaction [10.87%(5/46)] of the observation group were compared with these [93.47%(43/46)] and [8.70%(4/46)] of the control group (P>0.05). The observation group was shorter than the control group in the recovery time of intestinal gurgling sound, anal exhaust time, first defecation time, the recovery time of liquid diet and length of stay (P<0.05). After the treatment, the levels of Th1, Th1/Th2, CD3+,CD4+, CD4+/CD8+ of both groups increased than before the treatment, the levels of Th2, PCT, CRP, TNF-α and IL-6 reduced than before the treatment (P<0.05), and the improvements of the indexes above of the observation group were superior to these of the control group (P<0.05). ConclusionCiprofloxacin and modified Fulingpi decoction are effective in the treatment of postoperative infection for colorectal cancer, which could promote the recovery of gastrointestinal function, raise overall clinical effects, possibly related to effectively regulating Th1/Th2, immune function and degree of inflammatory response in vivo, with guaranteed safety of the combined treatment.

相似文献/References:

[1]雷琛,杨婕,蒋理立,等.结直肠癌患者术前疾病不确定感的影响因素及治疗性沟通护理的意义[J].西部中医药,2018,31(05):121.
 LEI Chen,YANG Jie,JIANG Lili,et al.On Influencing Factors of Illness Uncertainty of the Patients before the Surgery of Colorectal Cancer and the Meaning of Therapeutic Communication Nursing[J].Western Journal of Traditional Chinese Medicine,2018,31(04):121.
[2]宫姣,李艳,郝庆.泽泻醇-B-乙酸酯对结直肠癌HCT116细胞增殖和周期的影响[J].西部中医药,2017,30(03):22.
 GONG Jiao,LI Yan,HAO Qing.Effect of Alisol-B-acetate on Proliferation and Cycle of Colorectal Cancer Cell Line HCT116[J].Western Journal of Traditional Chinese Medicine,2017,30(04):22.
[3]胡春娜.老年晚期结直肠癌患者术后早期中医辨证分型及预后标志物表达情况分析[J].西部中医药,2017,30(10):61.
 HU Chunna.The Investigation into Syndrome Differentiation and Classfication of the Elderly Patients after the Surgery of Terminal Rectal Cancer at Early Stage and the Analysis on the Expressions of Prognostic Markers[J].Western Journal of Traditional Chinese Medicine,2017,30(04):61.
[4]苗翠影,冉光辉,王雪雁,等.结直肠癌的土家族医诊疗技法[J].西部中医药,2019,32(05):38.
 MIAO Cuiying,RAN Guanghui,WANG Xueyan,et al.Diagnostic and Therapeutic Techniques of the Tujia Ethnic Group Medicine for Colorectal Cancer[J].Western Journal of Traditional Chinese Medicine,2019,32(04):38.
[5]葛韵芝,许寅,丁超.基于网络药理学分析四君子汤治疗结直肠癌的作用机制[J].西部中医药,2021,34(08):84.[doi:10.12174/j.issn.2096-9600.2021.08.18]
 GE Yunzhi,XU Yin,DING Chao.Research on the Mechanism of Sijunzi Decoction in the Treatment of Colorectal Cancer Based on Network Pharmacology[J].Western Journal of Traditional Chinese Medicine,2021,34(04):84.[doi:10.12174/j.issn.2096-9600.2021.08.18]
[6]李萌,黄学武.参芪归脾汤加味内服和保留灌肠对结直肠癌化疗患者的影响[J].西部中医药,2021,34(01):106.[doi:10.12174/j.issn.2096-9600.2021.01.28]
 LI Meng,HUANG Xuewu.Effects of Oral Administration and Retention Enema of Modified Shenqi Guipi Decoction on the Patients with Colorectal Cancer after Chemotherapy[J].Western Journal of Traditional Chinese Medicine,2021,34(04):106.[doi:10.12174/j.issn.2096-9600.2021.01.28]
[7]王奇钰,吴晗,唐立垚,等.黄芪多糖对VEGF-C表达的抑制与结直肠癌细胞内淋巴管生成的相关性研究[J].西部中医药,2023,36(03):47.[doi:10.12174/j.issn.2096-9600.2023.03.09]
 WANG Qiyu,WU Han,TANG Liyao,et al.Correlation Study on the Inhibition of VEGF-C Expression by Astragalus Polysaccharides and Lymphangiogenesis in Colorectal Cancer Cells[J].Western Journal of Traditional Chinese Medicine,2023,36(04):47.[doi:10.12174/j.issn.2096-9600.2023.03.09]
[8]张钟玥,吴煜.基于气机升降理论探讨健脾化痰法在结直肠癌治疗中的应用[J].西部中医药,2023,36(07):95.[doi:10.12174/j.issn.2096-9600.2023.07.23]
 ZHANG Zhongyue,WU Yu.Application of Invigorating-spleen and Resolving-phlegm Method in the Treatment of Colorectal Cancer Based on Qi Movement Theory[J].Western Journal of Traditional Chinese Medicine,2023,36(04):95.[doi:10.12174/j.issn.2096-9600.2023.07.23]
[9]牛海珍,尹志朋,潘瑞,等.复合保温策略对老年结直肠癌手术患者术中非计划性低体温的影响[J].西部中医药,2023,36(08):78.[doi:10.12174/j.issn.2096-9600.2023.08.19]
 NIU Haizhen,YIN Zhipeng,PAN Rui,et al.Effects of Composite Insulation Strategy on Intraoperative Unplanned Hypothermia in Elderly Patients undergoing Colorectal Cancer Surgery[J].Western Journal of Traditional Chinese Medicine,2023,36(04):78.[doi:10.12174/j.issn.2096-9600.2023.08.19]
[10]李威,林珠,刘晓燕,等.穴位按压对老年转移性结直肠癌维持治疗患者癌因性疲乏的干预效果[J].西部中医药,2024,37(07):143.[doi:10.12174/j.issn.2096-9600.2024.07.34]
 LI Wei,LIN Zhu,LIU Xiaoyan,et al.Intervention Effect of Acupressure on Cancer-related Fatigue in Elderly Patients with Metastatic Colorectal Cancer Undergoing Maintenance Treatment[J].Western Journal of Traditional Chinese Medicine,2024,37(04):143.[doi:10.12174/j.issn.2096-9600.2024.07.34]

备注/Memo

备注/Memo:
阿地力江·阿力甫(1985—),男,主管药师。研究方向:医院药学。新疆维吾尔自治区自然科学基金(2017D01C019)。
更新日期/Last Update: 2023-04-15