[1]王永,陈萌.化瘀通便汤对慢传输型便秘患者血浆胃动素及结肠动力的影响[J].西部中医药,2023,36(05):94-97.[doi:10.12174/j.issn.2096-9600.2023.05.21]
　WANG Yong,CHEN Meng.Influence of Stagnation-resolving Bowel-relaxing Decoction on Plasma Gastrin and Colon Dynamics in Patients with Slow Transit Constipation[J].Western Journal of Traditional Chinese Medicine,2023,36(05):94-97.[doi:10.12174/j.issn.2096-9600.2023.05.21]
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化瘀通便汤对慢传输型便秘患者血浆胃动素及结肠动力的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年05期
页码:
94-97
栏目:
出版日期:
2023-05-15

文章信息/Info

Title:
Influence of Stagnation-resolving Bowel-relaxing Decoction on Plasma Gastrin and Colon Dynamics in Patients with Slow Transit Constipation
作者:
王永, 陈萌
辽宁中医药大学附属第三医院，辽宁 沈阳 110000
Author(s):
WANG Yong, CHEN Meng
The Third Affiliated Hospital to Liaoning University of Traditional Chinese Medicine, Shenyang 110000, China
关键词:
慢传输型便秘; 胃动素; 结肠动力; 化瘀通便汤
Keywords:
slow transit constipation; gastrin; colon dynamics; stagnation-resolving bowel-relaxing decoction
分类号:
R256.35
DOI:
10.12174/j.issn.2096-9600.2023.05.21
文献标志码:
B
摘要:
目的探讨化瘀通便汤对慢传输型便秘（slow transit constipation，STC）患者血浆胃动素及结肠动力的影响。 方法将124例STC患者根据随机数字表法分为观察组60例和对照组64例，观察组采取化瘀通便汤治疗，对照组采取麻仁润肠丸治疗，治疗1个月后比较治疗前后两组患者便秘症状、中医证候积分、胃动素（motilin，MLT）水平、结肠传输试验标志物排出情况及临床疗效。 结果治疗后两组患者便秘症状积分、中医证候积分及72 h内结肠残留标志物均低于治疗前（P＜0.05），观察组低于对照组（P＜0.05）；两组MTL水平均高于治疗前（P＜0.05），观察组高于对照组（P＜0.05）；总有效率观察组高于对照组（P＜0.05）。 结论化瘀通便汤在改善STC患者临床症状，提高临床疗效方面优于麻仁润肠丸，其机制可能与提高患者MLT水平、改善结肠动力有关。
Abstract:
ObjectiveTo discuss the influence of stagnation-resolving bowel-relaxing decoction on plasma gastrin and colon dynamics in patients with slow transit constipation (STC). MethodsAll 124 STC patients were allocated to 60 cases in the observation group and 64 cases in the control group according to random number table method, the observation group was treated with stagnation-resolving bowel-relaxing decoction, and the control group with Maren Runchang pills, after one month of treatment, to compare the symptoms of constipation, TCM syndrome integrals, MTL levels, the discharge of colonic transit test markers and clinical effects before and after treatment between both groups. ResultsAfter the treatment, the scores of defecation, TCM syndrome integrals and colon residual markers within 72 h of the patients in both groups were lower than these before the treatment (P<0.05), the observation group was lower than the control group (P<0.05); the levels of MTL of both groups were higher than these before the treatment (P<0.05), the observation group was higher than the control group (P<0.05); total effective rate of the observation group was higher than that of the control group (P<0.05). ConclusionStagnation-resolving bowel-relaxing decoction could effectively improve clinical symptoms in STC patients, and raise clinical effects, its mechanism might be related to raising the levels of MLT and improving colon dynamics.

相似文献/References:

[1]郑仁省.半夏泻心汤治疗胃病188例[J].西部中医药,2016,29(02):103.
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[2]王栋良,马鑫文.腹部推拿对慢传输型便秘大鼠神经递质及5-HT受体表达的调节作用[J].西部中医药,2021,34(07):29.[doi:10.12174/j.issn.2096-9600.2021.07.07]
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备注/Memo

备注/Memo:
王永（1981—），男，硕士学位，副主任医师。研究方向：肛肠疾病的诊治。国家自然科学基金青年科学基金（81804094）。
更新日期/Last Update: 2023-05-15