[1]艾尼瓦尔·塔力甫,伊力范江·库尔班,热甫哈提·赛买提,等.维吾尔医成熟剂对大鼠肝脏能量代谢相关因子的影响[J].西部中医药,2023,36(07):82-86.[doi:10.12174/j.issn.2096-9600.2023.07.20]
　Aniwar· TALIP,Yilifanjiang· KUERBAN,Rapkat SAMAT,et al.Effects of Uyghur Medicine Maturing Agents on the Related Factors of Liver Energy Metabolism in Rats[J].Western Journal of Traditional Chinese Medicine,2023,36(07):82-86.[doi:10.12174/j.issn.2096-9600.2023.07.20]
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维吾尔医成熟剂对大鼠肝脏能量代谢相关因子的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年07期
页码:
82-86
栏目:
出版日期:
2023-07-15

文章信息/Info

Title:
Effects of Uyghur Medicine Maturing Agents on the Related Factors of Liver Energy Metabolism in Rats
作者:
艾尼瓦尔·塔力甫1, 伊力范江·库尔班2, 热甫哈提·赛买提1, 阿依努尔·吾买尔江1, 阿地拉·吾拉因1, 依帕尔克孜·艾尼瓦尔1
1.新疆维吾尔自治区维吾尔医医院/新疆维吾尔自治区第二人民医院，新疆 乌鲁木齐 830049
2.新疆维吾尔药业有限责任公司，新疆 乌鲁木齐 830026
Author(s):
Aniwar· TALIP1, Yilifanjiang· KUERBAN2, Rapkat SAMAT1, Ayinuer WUMAIERJIANG1, Adila WULAYIN1, Yipaerkezi AINIWAR1
1.Hospital of Uygur Medicine, Xinjiang Uygur Autonomous Region/ Xinjiang Uygur Autonomous Region Second People's Hospital, Urumqi 830049, China
2.Xinjiang Uygur Pharmaceutical CO., LTD, Urumqi 830026, China
关键词:
维吾尔医; 成熟剂; 能量代谢
Keywords:
Uyghur medicine; maturing agents; energy metabolism
分类号:
R965.1
DOI:
10.12174/j.issn.2096-9600.2023.07.20
文献标志码:
A
摘要:
目的探讨5种维吾尔医成熟剂对大鼠肝脏能量代谢相关因子的影响。 方法将清洁级SD雄性大鼠随机分为空白对照组、血液质调节剂组、黏液质成熟剂组、胆液质成熟剂组、脾液质成熟剂组和胆液质调节剂组，每组8只。空白对照组予等量蒸馏水，其余各组剂量均为《中华人民共和国药典》人用高限剂量等效剂量的5倍，连续灌胃30天后，观察大鼠体质量；采用酶联免疫吸附法（enzyme-linked immunosorbent assay，ELISA）检测大鼠肝组织Na+-K+ ATP酶、Ca2+-Mg2+ATP酶和琥珀酸脱氢酶（succinate dehydrogenase，SDH）活性、肝糖原（hepatic glycogen，HG）和肌糖原（muscle glycogen，MG）含量；检测血浆三碘甲状腺原氨酸（triiodothyronine，T3）、四碘甲状腺原氨酸（tetraiodothyronine，T4）、促甲状腺激素（thyroid stimulating hormone，TSH）含量。 结果血液质调节剂可减轻大鼠体质量，胆液质调节剂可增加大鼠体质量，脾液质成熟剂、黏液质成熟剂能增加大鼠Na+-K+ATP酶、Ca2+-Mg2+ATP酶及SDH活力，增加HG、MG、T3、T4和TSH含量，血液质调节剂组、胆液质成熟剂组、胆液质调节剂组对能量代谢相关因子影响不显著。 结论5种维药成熟剂对正常大鼠肝脏能量代谢相关因子影响显著，与升高血清甲状腺素水平有关，其中脾液质成熟剂、黏液质成熟剂组作用显著。
Abstract:
ObjectiveTo discuss the influences of five kinds of Uyghur medicine maturing agents on the related factors of liver energy metabolism in rats. MethodsClean-grade SD male rats were randomized into blank control group, blood quality regulator group, mucus maturating agent group, biliary fluid maturing agent group, sediment maturing agent group and biliary fluid regulator group, with eight rats in each group. Blank control group accepted equivalent amount of distilled water, and the dose in the remaining groups was five times the equivalent dose of the high limit dose for human use of the Pharmacopoeia of the People's Republic of China, to observe rats' body weights after intragastric administration for 30 days consecutively; ELISA method was used to detect the activity of Na+-K+ ATP enzyme, Ca2+-Mg2+ ATP enzyme and SDH in liver tissue, and the contents of HG and MG; to measure the contents of T3, T4 and TSH in the blood plasma. ResultsBlood quality regulators could reduce rats’ body weights, biliary fluid regulator could put on rats’ body weight, sediment maturing agent and mucus maturating agent could increase the activity of Na+-K+ ATP enzyme, Ca2+-Mg2+ ATP enzyme and SDH, add the contents of HG, MG, T3 and T4, while the influences of blood quality regulator, biliary fluid maturing agent and biliary fluid regulator were insignificant on the related factors of energy metabolism. ConclusionFive kinds of Uyghur medicine maturing agents presented significant influence on the related factors of liver energy metabolism in normal rats, involving raising the levels of serum thyroid hormone, among them, sediment maturing agent and mucus maturating agent show the significant effects.

相似文献/References:

[1]伊力范江·库尔班,阿提坎木·瓦合甫,买买提依力·努尔买提,等.慢性胃炎的维吾尔医证候分布规律研究[J].西部中医药,2023,36(09):83.[doi:10.12174/j.issn.2096-9600.2023.09.18]
　Yilifanjiang· KUERBAN,Atikanmu· WAHEFU,Maimaitiyili· NUERMAITI,et al.Study on the Distribution Rules of Uygur Syndrome of Chronic Gastritis[J].Western Journal of Traditional Chinese Medicine,2023,36(07):83.[doi:10.12174/j.issn.2096-9600.2023.09.18]

备注/Memo

备注/Memo:
艾尼瓦尔·塔力甫（1973—），男，博士学位，主任药师。研究方向：维药制剂的研制与开发。国家科技重大专项（2017ZX09301045）。
更新日期/Last Update: 2023-07-15