[1]陈秀芝,哈团结,杨真,等.糖肾灌肠方保留灌肠联合前列地尔治疗Ⅳ期糖尿病肾病临床观察[J].西部中医药,2023,36(08):90-93.[doi:10.12174/j.issn.2096-9600.2023.08.22]
　CHEN Xiuzhi,HA Tuanjie,YANG Zhen,et al.Clinical Observation on Tangshen Enema Prescription Retention Enema Combined with Alprostadil in the Treatment of Ⅳ Stage Diabetic Kidney Disease[J].Western Journal of Traditional Chinese Medicine,2023,36(08):90-93.[doi:10.12174/j.issn.2096-9600.2023.08.22]
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糖肾灌肠方保留灌肠联合前列地尔治疗Ⅳ期糖尿病肾病临床观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年08期
页码:
90-93
栏目:
出版日期:
2023-08-15

文章信息/Info

Title:
Clinical Observation on Tangshen Enema Prescription Retention Enema Combined with Alprostadil in the Treatment of Ⅳ Stage Diabetic Kidney Disease
作者:
陈秀芝, 哈团结, 杨真, 邹斌, 刘珊珊, 程方浩
太和县中医院，安徽 太和 236600
Author(s):
CHEN Xiuzhi, HA Tuanjie, YANG Zhen, ZOU Bin, LIU Shanshan, CHENG Fanghao
Taihe Hospital of Traditional Chinese Medicine, Taihe 236600, China
关键词:
糖尿病肾病; Ⅳ期; 前列地尔; 糖肾灌肠方; 保留灌肠; 临床疗效; 血肌酐; 尿微量白蛋白/尿肌酐比值; 胱抑素C
Keywords:
diabetic kidney disease; stage Ⅳ; alprostadil; enema prescription; retention enema; clinical effects; serum creatinine; ACRCys-C
分类号:
R587.2
DOI:
10.12174/j.issn.2096-9600.2023.08.22
文献标志码:
B
摘要:
目的探讨糖肾灌肠方保留灌肠联合前列地尔治疗Ⅳ期糖尿病肾病（diabetic kidney disease，DKD）的临床疗效及对血肌酐、尿微量白蛋白/尿肌酐比值（urinary albumin-to-creatinine ratio，ACR）、血清胱抑素C（cystatin C，Cys-C）水平的影响。 方法将122例Ⅳ期DKD患者采用随机数字表法分为对照组和观察组，每组各61例。两组均给予基础治疗，对照组给予前列地尔治疗，观察组在对照组的基础上加糖肾灌肠方保留灌肠治疗，两组共干预2周。观察两组中医证候积分，血肌酐、ACR、Cys-C、血尿素氮、空腹血糖、糖化血红蛋白、甘油三酯、总胆固醇水平，统计临床疗效。 结果观察组治疗有效率［80.33%（49/61）］高于对照组［62.71%（37/59）］（P＜0.05）。治疗后，两组中医证候积分、血肌酐、ACR、Cys-C、尿素氮、甘油三酯、总胆固醇、空腹血糖及糖化血化蛋白水平均低于治疗前（P＜0.05），且观察组治疗后上述指标均低于对照组（P＜0.05）。 结论糖肾灌肠方保留灌肠联合前列地尔治疗Ⅳ期DKD可降低血肌酐、ACR、Cys-C水平，改善肾脏功能，减轻中医证候积分，提高治疗效果。
Abstract:
ObjectiveTo discuss clinical effects of Tangshen enema prescription retention enema and alprostadil in treating stage Ⅳ diabetic kidney disease (DKD) and its influence on the levels of serum creatinine (SCr), ACR and Cys-C. MethodsAll 122 cases of stage Ⅳ DKD were divided into the control group and the observation group using random number table method, with 61 cases in each group. Both groups were given basic therapy, and the control group was treated by alprostadil, the observation group by Tangshen enema prescription retention enema based on alprostadil. To observe syndrome integrals, the levels of SCr, ACR, Cys-C, blood urea nitrogen (BUN), fasting blood glucose, glycosylated hemoglobin, triglyceride and total cholesterol (TC) in both groups, and to count clinical effects. ResultsThe effective rate of the observation group was [80.33%(49/61)], higher than [62.71%(37/59)] of the control group (P<0.05). After the treatment, syndrome integrals, the levels of SCr, ACR, Cys-C, BUN, triglyceride and TC, fasting blood glucose and glycosylated hemoglobin of both groups after treatment were lower than these before the treatment (P<0.05), and the observation group was lower than the control group in these indexes after the treatment (P<0.05). ConclusionTangshen enema prescription retention enema and alprostadil in treating stage Ⅳ DKD could lower the levels of SCr, ACR and Cys-C, improve renal function, reduce syndrome integrals and raise therapeutic effects.

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备注/Memo

备注/Memo:
陈秀芝（1984—），女，硕士学位，副主任医师。研究方向：内分泌及代谢性疾病的中西医诊治。阜阳市自筹经费科技计划项目（FK202081118）；2021年度安徽中医药大学临床科研项目（2021LCTH32）。
更新日期/Last Update: 2023-08-15