七十味珍珠丸抗阿尔兹海默病的临床应用、药理作用及其机制研究进展-《西部中医药》

文章信息/Info

Title:: Research Progress on Clinical Application, Pharmacological Effect and the Mechanism of Ratnasampil Against Alzheimer′s Disease

作者:: 张玉香¹, 顾志荣², 李钦¹, 吴国泰³, 李海龙³, 李芳³; 1.甘肃卫生职业学院，甘肃兰州 730207
2.甘肃省人民医院，甘肃兰州 730000
3.甘肃中医药大学，甘肃兰州 730000

Author(s):: ZHANG Yuxiang¹, GU Zhirong², LI Qin¹, WU Guotai³, LI Hailong³, LI Fang³; 1.Gansu Province Health School, Lanzhou 730207, China
2.Gansu Provincial Hospital, Lanzhou 730000, China
3.Gansu University of Chinese Medicine, Lanzhou 730000, China

Keywords:: Alzheimer's disease; Ratnasampil; clinical study; pharmacological study; mechanism

摘要:: 藏药七十味珍珠丸（Tibetan medicine ratnasampil，RNSP）是预防和治疗阿尔兹海默病（Alzheimer′s disease，AD）的前景药物，对防治轻、中度AD具有很好的临床应用价值。RNSP能显著改善轻、中度AD患者的认知功能和日常生活自理能力，具有改善记忆、修复大脑神经元、提高学习记忆能力、改善大脑氧化应激（oxidative stress，OS）水平等药理作用。RNSP抗AD的机制可能是通过保护神经，降低大脑中和AD相关的β淀粉样蛋白（amyloid，Aβ）水平，抵抗大脑慢性炎症，减少炎症因子激活及抗OS等产生的。建议开展较大规模的多中心随机对照双盲实验，进一步确定RNSP预防和治疗AD的临床价值，并在分子和基因水平加强其药理机制探讨。

Abstract:: Tibetan medicine Ratnasampil (RNSP) is a prospective drug for the prevention and treatment of Alzheimer's disease (AD), and it has good clinical application value for the prevention and treatment of mild to moderate AD. RNSP can significantly improve mild to moderate AD patients' cognitive function and self-care ability in daily life owing to its pharmacological effects of improving memory, repairing brain neurons, improving learning and memorization skills and the levels of cerebral oxidative stress. Its mechanism of anti-AD might be realized by protecting nerves, reducing the expressions of AD-related amyloid (Aβ) in the brain, resisting chronic inflammation of the brain, reducing inflammatory factors activation and anti-oxidative stress (OS). Therefore, larger scale multicenter randomized controlled double-blind trials should be recommended in order to further ensure its clinical value in the prevention and treatment of AD, and its pharmacological mechanism should be discussed at the molecular and genetic levels.