[1]吴芳,刘素珍,刘丽芳.舒乳解郁汤联合穴位贴敷治疗乳腺癌术后抑郁失眠临床疗效观察[J].西部中医药,2023,36(12):113-116.[doi:10.12174/j.issn.2096-9600.2023.12.25]
　WU Fang,LIU Suzhen,LIU Lifang.Clinical Observation on Shuru Jieyu Tang and Acupoint Application in the Treatment of Postoperative Depression and Insomnia of Breast Cancer[J].Western Journal of Traditional Chinese Medicine,2023,36(12):113-116.[doi:10.12174/j.issn.2096-9600.2023.12.25]
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舒乳解郁汤联合穴位贴敷治疗乳腺癌术后抑郁失眠临床疗效观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年12期
页码:
113-116
栏目:
衷中参西
出版日期:
2023-12-15

文章信息/Info

Title:
Clinical Observation on Shuru Jieyu Tang and Acupoint Application in the Treatment of Postoperative Depression and Insomnia of Breast Cancer
作者:
吴芳, 刘素珍, 刘丽芳
湖南中医药大学第一附属医院，湖南 长沙 410008
Author(s):
WU Fang, LIU Suzhen, LIU Lifang
The First Hospital of Hunan University of Chinese Medicine, Changsha 410008, China
关键词:
失眠; 抑郁; 乳腺癌术; 中医经络理论; 舒乳解郁汤; 中药穴位贴敷; 临床疗效
Keywords:
insomnia; depression; after breast cancer; TCM therapy of meridian and collateral; herbal acupoint application; clinical effects
分类号:
R737.9
DOI:
10.12174/j.issn.2096-9600.2023.12.25
文献标志码:
B
摘要:
目的对舒乳解郁汤联合中药穴位贴敷治疗乳腺癌术后抑郁失眠进行临床观察。 方法选取乳腺癌术后抑郁患者137例，分为观察组（68例）与对照组（69例）。对照组予常规西医治疗方案治疗，观察组在此基础上联合舒乳解郁汤及穴位贴敷治疗，连续干预6周。评价工具为匹兹堡睡眠质量指数（Pittsburgh sleep quality index，PSQI）量表、汉密尔顿抑郁量表（Hamilton Depression Scale，HAMD），同时比较两组临床疗效及血清P物质（Substance P，SP）、血清5羟色胺（5-hydroxytryptamine，5-HT）、神经肽Y（neuropeptide Y，NPY）水平，并进行安全性评价。 结果PSQI评分、HAMD评分治疗后两组均显著低于治疗前（P＜0.01），且观察组下降幅度大于对照组（P＜0.05）。治疗后血清SP水平观察组明显低于对照组（P＜0.01），5-HT、NPY水平观察组明显高于对照组（P＜0.01）。观察组总有效率［92.65%（63/68）］高于对照组［83.82%（57/68）］（P＜0.01）。观察组不良反应发生率［10.29%（7/68）］低于对照组［30.43%（21/69）］（P＜0.01）。 结论舒乳解郁汤联合穴位贴敷治疗乳腺癌术后抑郁失眠安全有效，能够显著提升患者的睡眠质量和生活质量。
Abstract:
ObjectiveTo observe clinical effects of Shuru Jieyu Tang and herbal acupoint application in the treatment of postoperative depression and insomnia of breast cancer. MethodsAll 137 patients were randomized into the observation group (68 cases) and the control group (69 cases). The control group was treated by routine therapeutic regimen of Western medicine, and the observation group Shuru Jieyu Tang and herbal acupoint application, for six weeks consecutively. The evaluation tools were Pittsburgh sleep quality index and Hamilton Depression Scale (HAMD), simultaneously to compare clinical effects, the levels of SP, 5-HT and NPY between both groups, and to carry out the safety assessment. ResultsAfter the treatment, PSQI and HAMD scores were noticeably lower than these before the treatment (P<0.01), and the decrease of the observation group was greater than that of the control group (P<0.05). After the treatment, the levels of serum SP in the observation group were remarkably lower than these of the control group (P<0.01), the observation group was obviously higher than the control group in the levels of 5-HT and NPY (P<0.01). Total effective rate of the observation group was [92.65%(63/68)], higher than [83.82%(57/68)] of the control group (P<0.01). The incidence of adverse reaction of the observation group was [10.29%(7/68)], lower than [30.43%(21/69)] of the control group (P<0.01). ConclusionShuru Jieyu Tang and herbal acupoint application is safe and effective in the treatment of postoperative depression and insomnia of breast cancer, which could noticeably improve the patients' sleep quality and quality of life.

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备注/Memo

备注/Memo:
吴芳（1974—），女，主管护师。研究方向：乳腺疾病的中医药综合治疗及护理。国家自然科学基金（81473680）；湖南省教育厅科研项目（20C1439）；湖南省卫生厅科研自筹基金（HKJ18ZC42）。
更新日期/Last Update: 2023-12-15