[1]高健,赵飞,张朵朵,等.参芪地黄汤联合二甲双胍治疗2型糖尿病疗效及对患者氧化应激的影响[J].西部中医药,2024,37(03):99-102.[doi:10.12174/j.issn.2096-9600.2024.03.19]
　GAO Jian,ZHAO Fei,ZHANG Duoduo,et al.Clinical Effects of Shenqi Dihuang Tang Combined with Metformin in the Treatment of Type Two Diabetes Mellitus and Its Influence on Oxidative Stress[J].Western Journal of Traditional Chinese Medicine,2024,37(03):99-102.[doi:10.12174/j.issn.2096-9600.2024.03.19]
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参芪地黄汤联合二甲双胍治疗2型糖尿病疗效及对患者氧化应激的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年03期
页码:
99-102
栏目:
临床研究
出版日期:
2024-03-15

文章信息/Info

Title:
Clinical Effects of Shenqi Dihuang Tang Combined with Metformin in the Treatment of Type Two Diabetes Mellitus and Its Influence on Oxidative Stress
作者:
高健1, 赵飞1, 张朵朵1, 夏长青2
1.河北省优抚医院，河北 石家庄 050051
2.石家庄市中医医院，河北 石家庄 050051
Author(s):
GAO Jian1, ZHAO Fei1, ZHANG Duoduo1, XIA Changqing2
1.Hebei Provincial Special Care Hospital, Shijiazhuang 050051, China
2.Shijiazhuang Hospital of Traditional Chinese Medicine, Shijiazhuang 050051, China
关键词:
2型糖尿病; 氧化应激; 参芪地黄汤; 二甲双胍; 临床疗效
Keywords:
type two diabetes mellitus; oxidative stress; metformin; clinical effect
分类号:
R259
DOI:
10.12174/j.issn.2096-9600.2024.03.19
文献标志码:
B
摘要:
目的观察参芪地黄汤联合二甲双胍治疗2型糖尿病（type 2 diabetes mellitus，T2DM）的临床疗效及对T2DM患者氧化应激的影响。 方法将94例T2DM患者按就诊顺序随机分为观察组与对照组各47例，对照组在基础治疗基础上口服二甲双胍，观察组在对照组基础上口服参芪地黄汤，15天为1个疗程，共治疗3个疗程。采用化学比色法检测治疗前后两组患者超氧化物歧化酶（superoxide dismutase，SOD）、丙二醛（malonaldehyde，MDA）水平；采用酶联免疫吸附法检测谷胱甘肽过氧化氢酶（glutathione catalase，GSH-PX）、活性氧（reactive oxygen species，ROS）水平；观察两组患者治疗前后血糖变化情况及临床疗效。 结果与治疗前相比，两组患者SOD、GSH-PX均升高（P＜0.05），MDA、ROS、空腹血糖、餐后2 h血糖、糖化血红蛋白均降低（P＜0.05），观察组改善更明显（P＜0.05）；总有效率观察组为93.62%（44/47），高于对照组的78.72%（37/47）。 结论参芪地黄汤联合二甲双胍能够改善T2DM患者血糖及氧化应激状态，疗效优于单用二甲双胍。
Abstract:
ObjectiveTo observe clinical effects of Shenqi Dihuang Tang and metformin in the treatment of type two diabetes mellitus (T2DM) and its influence on oxidative stress. MethodsAll 94 T2DM patients were separated into the observation group and the control group according to the visiting order, with 47 cases in each group, the control group orally took metformin, and the observation group accepted oral administration of Shenqi Dihuang Tang based on Western medicine, 15 days were one course of the treatment, and they were treated for three courses of the treatment. To detect the contents of SOD and MDA of the patients between both groups before and after the treatment using chemical colorimetric method, and to measure the contents of GSH-PX and ROS using ELISA; To observe the changes of blood glucose and clinical effects before and after the treatment between both groups. ResultsCompared with before the treatment, the levels of SOD and GSH-PX were increased in the two groups (P<0.05), the contents of MDA and ROS, fasting blood glucose, 2h postprandial plasma glucose and glycosylated hemoglobin were lowered (P<0.05), the improvements of the observation group were more noticeable (P<0.05); total effective rate of the observation group was 93.62%（44/47）, higher than 78.72%（37/47） of the control group. ConclusionShenqi Dihuang Tang in combination with metformin could improve the levels of blood glucose and oxidative stress in T2DM patients, and its clinical effects superior to these of metformin.

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　DAI Mei.Intervention of Comprehensive Nursing on Blood Glucose and Glycosylated Hemoglobin of Patients with Diabetes Mellitus Type Two[J].Western Journal of Traditional Chinese Medicine,2013,26(03):109.

备注/Memo

备注/Memo:
高健（1982—），男，硕士学位，主治医师。研究方向：心血管疾病的中西医结合研究。E-mail：489572580@qq.com。河北省卫生和计划生育委员会科研基金（20180893）。
更新日期/Last Update: 2024-03-15