[1]郁文恺,王凯,曹凯峰,等.血府逐瘀汤联合阿托伐他汀钙治疗高脂血症痰湿内阻证临床观察[J].西部中医药,2024,37(09):150-153.[doi:10.12174/j.issn.2096-9600.2024.09.34]
 YU Wenkai,WANG Kai,CAO Kaifeng,et al.Clinical Observation on Xuefu Zhuyu Tang Joined with Atorvastatin Calcium in the Treatment of Hyperlipidemia of Phlegm-dampness Internal Obstruction Pattern[J].Western Journal of Traditional Chinese Medicine,2024,37(09):150-153.[doi:10.12174/j.issn.2096-9600.2024.09.34]
点击复制

血府逐瘀汤联合阿托伐他汀钙治疗高脂血症痰湿内阻证临床观察
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年09期
页码:
150-153
栏目:
衷中参西
出版日期:
2024-09-15

文章信息/Info

Title:
Clinical Observation on Xuefu Zhuyu Tang Joined with Atorvastatin Calcium in the Treatment of Hyperlipidemia of Phlegm-dampness Internal Obstruction Pattern
作者:
郁文恺1, 王凯2, 曹凯峰3, 倪静1, 常琎文1
1.上海中医药大学附属静安区临汾路街道社区卫生服务中心,上海 200040
2.上海市松江区洞泾镇社区卫生服务中心,上海 201607
3.上海市第三康复医院,上海 200040
Author(s):
YU Wenkai1, WANG Kai2, CAO Kaifeng3, NI Jing1, CHANG Jinwen1
1.Linfen Road Street Community Health Service Center of Jing'an District Affiliated to Shanghai University of TCM, Shanghai 200040, China
2.Dongjing Community Health Service Center of Songjiang District, Shanghai 201607, China
3.Shanghai Third Rehabilitation Hospital, Shanghai 200040, China
关键词:
高脂血症痰湿内阻证血脂血管内皮功能阿托伐他汀钙血府逐瘀汤
Keywords:
hyperlipidemiaphlegm-dampness internal obstruction patternblood lipidvascular endothelial functionatorvastatin calcium
分类号:
R243
DOI:
10.12174/j.issn.2096-9600.2024.09.34
文献标志码:
B
摘要:
目的观察血府逐瘀汤加减联合阿托伐他汀钙治疗高脂血症痰湿内阻证的临床疗效。 方法将高脂血症痰湿内阻证患者74例按照随机数字表法分为对照组和观察组各37例,对照组口服阿托伐他汀钙治疗,观察组口服阿托伐他汀钙+血府逐瘀汤加减治疗,两组患者均以4周为1个疗程,共治疗2个疗程。比较两组患者血脂指标[总胆固醇(total cholesterol,TC)、甘油三酯(triglyceride,TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、高密度脂蛋白胆固醇(high-density lipoprotein-cholesterol,HDL-C)]、血管内皮功能指标[内皮素1(endothelins-1,ET-1)、一氧化氮(nitric oxide,NO)、6-酮-前列腺素F-1α(6-keto-PGF-1α)、血栓素B2(thromboxane B2,TXB2)]水平变化情况及临床疗效与不良反应发生情况。 结果治疗后两组患者LDL-C及TG、TC水平较治疗前降低(P<0.05),HDL-C较治疗前升高(P<0.05),组间比较差异有统计学意义(P<0.05);治疗后观察组患者6-keto-PGF-1α、NO水平较治疗前升高(P<0.05),TXB2、ET-1水平较治疗前降低(P<0.05),组间比较差异有统计学意义(P<0.05);观察组总有效率为94.6%(35/37),高于对照组的78.4%(29/37)(P<0.05);观察组不良反应发生率为27.0%(10/37),低于对照组的8.1%(3/37)(P<0.05)。 结论阿托伐他汀钙联合血府逐瘀汤可改善高脂血症痰湿内阻证患者血脂、血管内皮功能,提高临床疗效,降低不良反应发生率。
Abstract:
ObjectiveTo observe clinical effects of modified Xuefu Zhuyu Tang (Xuefu stasis-removing decoction) combined with atorvastatin calcium in the treatment of hyperlipidemia of phlegm-dampness internal obstruction pattern. MethodsAll 74 patients were allocated to the control group and the observation group according to random number table method with 37 cases in each group, the control group was treated by atorvastatin calcium tablets, and the observation group took atorvastatin calcium tablets and modified Xuefu Zhuyu Tang, four weeks were one course of the treatment, and both groups were treated for two courses of the treatment. To compare the levels of blood lipid indicators including TC, TG, LDL-C and HDL-C, the indexes of vascular endothelial function such as ET-1, NO, 6-keto-PGF-1α and TXB2, curative effects and the incidences of adverse reactions between the two groups. ResultsAfter the treatment, LDL-C, TG and TC levels in the two groups were lower than before the treatment (P<0.05), HDL-C levels elevated than pre-treatment levels (P<0.05), and the differences had statistical meaning between the groups (P<0.05), after the treatment, the levels of 6-keto-PGF-1α and NO went up than pre-treatment level in the observation group (P<0.05), TXB2 and ET-1 levels reduced than pre-treatment level (P<0.05), and the differences had statistical meaning between the groups (P<0.05), total effective rate of the observation group was 94.6% (35/37), higher than 78.4%(29/37) of the control group of the control group (P<0.05); the incidences of adverse reaction of the observation group was 27.0% (10/37), lower than 8.1% (3/37) of the control group (P<0.05). ConclusionAtorvastatin calcium and Xuefu Zhuyu Tang could improve blood lipid, vascular endothelial function, and clinical effects, and decrease the incidences of adverse reaction in treating phlegm-dampness internal obstruction type of hyperlipidemia.

相似文献/References:

[1]杨健,张红武△,杨如意.活血化浊胶囊治疗高脂血症的实验研究[J].西部中医药,2012,25(08):17.
 YANG Jian,ZHANG Hong-wu,YANG Ru-yi.Experimental Study on HuoXue HuaZhuo Capsule in Treating Hyperlipidemia[J].Western Journal of Traditional Chinese Medicine,2012,25(09):17.
[2]高艳琼,延华,金瑞瑞.泽泻汤治疗高脂血症的临床疗效观察[J].西部中医药,2015,28(09):88.
[3]高世东.从肝脾肾论治高脂血症[J].西部中医药,2013,26(06):18.
 GAO Shidong.On Hyperlipoidemia Treated from Liver, Spleen and Kidney[J].Western Journal of Traditional Chinese Medicine,2013,26(09):18.
[4]袁帆,张全华,冉子伯.降脂类中药组方治疗高脂血症临床观察[J].西部中医药,2014,27(05):85.
 YUAN Fan,ZHANG Quanhua,RAN Zibo.Clinical Observation on Lipid-lowering Herbs and Prescriptions in the Treatment for Hyperlipidemia[J].Western Journal of Traditional Chinese Medicine,2014,27(09):85.
[5]滕云.七味消脂饮治疗高脂血症临床观察[J].西部中医药,2013,26(05):77.
 TENG Yun.Clinical Observation on QiWei XiaoZhiYin in Treating Hyperlipoidemia[J].Western Journal of Traditional Chinese Medicine,2013,26(09):77.
[6]张和平,谈建新,王敬敏,等.心脑通配方对大鼠颈总动脉粥样硬化斑块中MMP-2的影响[J].西部中医药,2014,27(03):32.
 ZHANG Heping,TAN Jianxin,WANG Jingmin,et al.Effects of XinNaoTong Prescription on MMP-2 in Carotid Atherosclerotic Plaque of Rats[J].Western Journal of Traditional Chinese Medicine,2014,27(09):32.
[7]李龑,杨舒淳,吴芳,等.化脂丸对高脂血症患者血脂的影响*[J].西部中医药,2014,27(04):31.
 LI Yan,YANG Shuchun,WU Fang,et al.Effects of HuaZhi Pill on Blood Lipid of the Patients with Hyperlipemia[J].Western Journal of Traditional Chinese Medicine,2014,27(09):31.
[8]苏奋翔,张艳霞,安方玉,等.林氏降脂方对高脂血症大鼠血脂和血液流变学的影响[J].西部中医药,2015,28(10):12.
[9]苏奋翔,张艳霞,安方玉,等.林氏降脂方对高脂血症大鼠肾脏的影响[J].西部中医药,2016,29(04):22.
 SU Fenxiang,ZHANG Yanxia,AN Fangyu,et al.Effects of LinShiJiangZhi Prescription on the Kidney of the Rats with Hyperlipoidemia[J].Western Journal of Traditional Chinese Medicine,2016,29(09):22.
[10]李淑玲,刘凯△.李应东教授从脾气虚论治高脂血症[J].西部中医药,2017,30(03):53.
 LI Shuling,LIU Kai.Professor LI Yingdong′s Treatment for Hyperlipidemia from Spleen-Qi Deficiency[J].Western Journal of Traditional Chinese Medicine,2017,30(09):53.

备注/Memo

备注/Memo:
郁文恺(1989—),男,硕士学位,主治医师。研究方向:中医全科。2019年上海市“医苑新星”青年医学人才培养计划(沪卫人事〔2020〕87号)。
更新日期/Last Update: 2024-09-15