[1]杨浩,张康,谢凯,等.清金化痰汤加减辅助治疗重症肺炎有效性及安全性的Meta分析[J].西部中医药,2025,38(05):60-64.[doi:10.12174/j.issn.2096-9600.2025.05.12]
　YANG Hao,ZHANG Kang,XIE Kai,et al.Meta-analysis of the Effectiveness and Safety of Modified Qinjin Huatan Decoction as Adjuvant Therapy for Severe Pneumonia[J].Western Journal of Traditional Chinese Medicine,2025,38(05):60-64.[doi:10.12174/j.issn.2096-9600.2025.05.12]
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清金化痰汤加减辅助治疗重症肺炎有效性及安全性的Meta分析()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年05期
页码:
60-64
栏目:
二次研究
出版日期:
2025-05-15

文章信息/Info

Title:
Meta-analysis of the Effectiveness and Safety of Modified Qinjin Huatan Decoction as Adjuvant Therapy for Severe Pneumonia
作者:
杨浩1,2,3, 张康1,2,3, 谢凯1,2, 张庆1,2, 王海峰1,3
1.河南中医药大学第一附属医院，河南 郑州 450000
2.河南中医药大学，河南 郑州 450000
3.呼吸疾病中医药防治省部共建协同创新中心，河南 郑州 450000
Author(s):
YANG Hao1,2,3, ZHANG Kang1,2,3, XIE Kai1,2, ZHANG Qing1,2, WANG Haifeng1,3
1.The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
2.Henan University of Chinese Medicine, Zhengzhou 450000, China
3.Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases Co-constructed by Henan Province & Education Ministry of P.R. China, Zhengzhou 450000, China
关键词:
重症肺炎; 疗效; 安全性; Meta分析; 清金化痰汤
Keywords:
severe pneumonia; clinical efficacy; safety; Meta analysis; decoction
分类号:
R256.11
DOI:
10.12174/j.issn.2096-9600.2025.05.12
文献标志码:
A
摘要:
目的评价清金化痰汤加减辅助治疗重症肺炎的疗效及安全性。 方法系统检索CNKI、Wanfang DATA、VIP、SinoMed、EMbase、PubMed、Cochrane Library数据库，检索时间为建库至2021年8月20日，收集清金化痰汤加减辅助治疗重症肺炎的随机对照临床研究。采用NoteExpress软件进行文献筛选，RevMan 5.3软件进行数据分析。 结果纳入18项研究，共1412例患者，其中试验组706例，对照组706例。Meta分析结果显示：在临床疗效方面，清金化痰汤加减联合西医常规治疗优于西医常规治疗（RR=1.19，95%CI：1.12～1.28），P＜0.000 01）；在临床肺部感染评分（clinical pulmonary infection score，CPIS）方面，清金化痰汤加减联合西医常规治疗优于西医常规治疗（MD=-1.92，95%CI：-2.31～-1.53，P＜0.000 01）；在中医证候评分（traditional Chinese medicine syndrome score，TCMSS）方面，清金化痰汤加减联合西医常规治疗优于西医常规治疗（MD=-2.40，95%CI：-3.94～-0.86，P=0.002）；在住院时间方面，清金化痰汤加减联合西医常规治疗优于西医常规治疗（MD=-2.52，95%CI：-4.11～-0.93，P=0.002）；在机械通气时间方面，清金化痰汤加减联合西医常规治疗优于西医常规治疗（MD=-2.06，95%CI：-2.29～-1.83，P＜0.000 01）；在炎症指标CRP计数方面，清金化痰汤加减联合西医常规治疗优于西医常规治疗（MD=-9.43，95%CI：-12.76～-6.09，P＜0.000 01）。所纳入研究均未见严重不良反应。 结论清金化痰汤加减联合西医常规疗法治疗重症肺炎疗效优于单纯西医常规治疗，安全性较好，但纳入研究总体质量偏低，需要高质量的临床研究进一步验证清金化痰汤加减辅助治疗重症肺炎的有效性及安全性。
Abstract:
ObjectiveTo evaluate the efficacy and safety of modified Qingjin Huatan (lung-clearing phlegm-resolving) decoction as adjuvant treatment for severe pneumonia (SP). MethodsRandomized controlled clinical trials on modified Qingjin Huatan decoction as adjuvant treatment for SP were retrieved from CNKI, Wanfang data, VIP, SinoMed, EMbase, PubMed, Cochrane Library databases between the time of database establishment and August 20, 2021, NoteExpress software was applied for literature screening, and Revman 5.3 software was used for data analysis. ResultsAll 18 studies have been included, involving 1412 patients, among them, there were 706 cases in the experiment group and 706 cases in the control group. The results of Meta analysis showed that the combination of oral modified Qingjin Huatan decoction with conventional therapy of Western medicine was superior to only Western medicine in terms of the improvements of clinical effective rate (RR=1.19, 95%CI:1.12-1.28, P<0.000 01), the decrease of CPIS (MD=-1.92, 95%CI:-2.31 - -1.53, P<0.000 01), and the reduction of TCMSS (MD=-2.40, 95%CI:-3.94 - -0.86, P=0.002), as well as shortening the length of hospital stay (MD=-2.52, 95%CI:-4.11 - -0.93, P=0.002), reducing mechanical ventilation time (MD=-2.06, 95%CI:-2.29 - -1.83, P<0.000 01), and decreasing inflammatory marker CRP count (MD=-9.43, 95%CI:-12.76 - -6.09, P<0.000 01). No severe adverse reaction was found in the included studies. ConclusionOral modified Qingjin Huatan decoction combined with conventional therapy of Western medicine was superior to only Western medicine in the treatment of SP with better safety. But due to certain limitations existed in the study and lower overall quality of the included studies, high-quality clinical studies are needed to further verify the effectiveness and safety of the decoction as adjuvant therapy for SP.

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备注/Memo

备注/Memo:
杨浩（1994—），男，硕士学位。研究方向：中医药防治呼吸疾病。国家自然科学基金（81774222，82074411）；河南省中医药科学研究重大专项（20-21ZYZD04）；河南省中医药科学研究专项课题（拔尖人才）（2019ZYBJ05）；2022年度河南省高校科技创新团队支持计划（22IRTSTHN029）。
更新日期/Last Update: 2025-05-15