[1]唐伟丽,鲁毅,韩欣妍,等.基于网络药理学探讨玉屏风散治疗口腔扁平苔藓的作用机制[J].西部中医药,2025,38(05):88-93.[doi:10.12174/j.issn.2096-9600.2025.05.17]
　TANG Weili,LU Yi,HAN Xinyan,et al.Network Pharmacology-based Discussion on the Mechanism of Yupingfeng Powder in the Treatment of Oral Lichen Planus[J].Western Journal of Traditional Chinese Medicine,2025,38(05):88-93.[doi:10.12174/j.issn.2096-9600.2025.05.17]
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基于网络药理学探讨玉屏风散治疗口腔扁平苔藓的作用机制()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年05期
页码:
88-93
栏目:
二次研究
出版日期:
2025-05-15

文章信息/Info

Title:
Network Pharmacology-based Discussion on the Mechanism of Yupingfeng Powder in the Treatment of Oral Lichen Planus
作者:
唐伟丽1, 鲁毅1, 韩欣妍1, 李崇1, 赵芳2, 郭鹏琦3
1.西安交通大学口腔医院药剂科/陕西省颅颌面精准医学研究重点实验室，陕西 西安 710004
2.西北妇女儿童医院药剂科，陕西 西安 710061
3.西北大学化工学院，陕西 西安 710069
Author(s):
TANG Weili1, LU Yi1, HAN Xinyan1, LI Chong1, ZHAO Fang2, GUO Pengqi3
1.Department of Pharmacy,Hospital of Stomatology, Xi’an Jiaotong University/ Key laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, Xi’an 710004, China
2.Department of Pharmacy, Northwest Women’s and Children’s Hospital, Xi’an 710061, China
3.School of Chemical Engineering, Northwest University, Xi’an 710069, China
关键词:
口腔扁平苔藓; 网络药理学; 机制; 玉屏风散; 成分
Keywords:
oral lichen planus; network pharmacology; mechanism; powder; ingredients
分类号:
R276.8
DOI:
10.12174/j.issn.2096-9600.2025.05.17
文献标志码:
A
摘要:
目的利用网络药理学方法探讨玉屏风散治疗口腔扁平苔藓（oral lichen planus，OLP）的主要活性成分及作用机制。 方法利用中药系统药理学数据库与分析平台（traditional Chinese medicine systems pharmacology database and analysis platform，TCMSP）和人类基因数据库（the human gene database，GeneCards）获取玉屏风散的活性成分、作用靶点以及OLP疾病靶点；利用韦恩图分析获得药物与疾病共同靶点；利用STRING软件构建药物与疾病共同靶点蛋白-蛋白互作（protein-protein interactions，PPI）网络，并筛选关键靶点。通过基因功能注释数据库（the database for annotation visualization and integrated discovery，DAVID）对核心靶基因关键靶点进行基因本体论（gene ontology，GO）功能、京都基因与基因组百科全书（kyoto encyclopedia of genes and genomes，KEGG）通路富集分析。构建“药物-成分-靶点-通路”网络，获得主要活性成分，并将主要活性成分与关键靶点进行分子对接。 结果共筛选得到关键靶点11个，主要活性成分为槲皮素、汉黄芩素、山柰酚、芒柄花黄素、β-谷甾醇。富集分析发现正向调控RNA聚合酶Ⅱ启动子转录、促进一氧化氮生物合成、Toll样受体、MAPK及T细胞受体介导的信号通路等与OLP相关。分子对接结果表明主要活性成分与关键靶点有一定作用力。 结论玉屏风散治疗OLP具有多靶点、多通路等特点，其可能通过抑制机体炎性反应，改善免疫功能，抑制OLP癌变，发挥治疗OLP的作用。
Abstract:
ObjectiveTo discuss the main active ingredients and mechanism of Yupingfeng powder in the treatment of oral lichen planus (OLP) using network pharmacology. MethodsTCMSP and GeneCards were applied to obtain the active ingredients, targets of action of Yupingfeng powder and OLP - related targets, Venn diagram was utilized to analyze and gain shared targets between medicine and disease. STRING software was used to construct PPI of the shared targets between medicine and disease for the screening of key targets. Go and KEGG of the key targets and core target genes were conducted using DAVID. The network of "medicine-ingredient-target-pathway" was built to obtain the main active ingredients, and to perform molecular docking of the main active ingredients and key targets. ResultsAll 11 key targets were screened and obtained in the study, the main active ingredients were quercetin, baicalin, kaempferol, flavanthone and β-glucosinolide. The results of enrichment analysis showed that these factors including the transcription of positive regulation of RNA polymerase II promoter, promoting nitric oxide biosynthesis, toll-like receptor, MAPK and T cell receptor mediated signaling pathways, were closely related to OLP. The results of molecular docking demonstrated that there was a certain interaction between the main active ingredients and key targets. Conclusion Yupingfeng powder in treating OLP, possessing the characteristics of multiple targets and multiple pathways, could exert therapeutic effects of OLP possibly through inhibiting inflammatory reaction, improving immunologic function and restraining OLP carcinogenesis.

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备注/Memo

备注/Memo:
唐伟丽（1987—），女，硕士学位，药师。研究方向：口腔药学与临床药学。国家重点研发计划“中医药现代化研究”重点专项（2019YFC1710101）。 国家自然科学基金青年科学基金（82000284）；陕西省自然科学基金（2020JQ-609）；中国博士后科学基金（2020M683701XB）；西安交通大学口腔医院青年科研基金项目（201704）。
更新日期/Last Update: 2025-05-15