补肾益精中药防治糖尿病骨质疏松症的作用机制研究进展-《西部中医药》

文章信息/Info

Title:: Research Progress on the Mechanism of Preventing and Treating Diabetes Osteoporosis with Kidney-invigorating Essence-replenishing Herbs

作者:: 周小青¹, 马兰¹, 张亚静¹, 丁娟娟¹, 王晓晖^2,3; 1.甘肃中医药大学，甘肃兰州 730030
2.甘肃省中医药研究院，甘肃兰州 730050
3.甘肃省中医院，甘肃兰州 730050

Author(s):: ZHOU Xiaoqing¹, MA Lan¹, ZHANG Yajing¹, DING Juanjuan¹, WANG Xiaohui^2,3; 1.Gansu University of Chinese Medicine, Lanzhou 730030, China
2.Gansu Provincial Academy of Chinese Medicine,Lanzhou 730050,China
3.Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China

Keywords:: diabetes osteoporosis; kidney-invigorating essence-replenishing; bone metabolism; molecular mechanism

摘要:: 对糖尿病骨质疏松症（diabetes osteoporosis，DOP）的骨代谢相关信号通路及防治DOP的补肾益精中药做一综述，DOP的骨代谢相关信号通路主要包括Wnt/β-catenin、MAPK、NF-κB、Notch和OPG/RANKL/RANK信号通路，防治DOP的补肾益精中药主要有熟地黄、鹿角胶、菟丝子、山茱萸等。这些中药的有效成分能够通过调控Wnt/β-catenin、MAPK、NF-κB等信号通路稳定骨骼代谢平衡，从而发挥补肾益精、强筋健骨之效，达到治疗DOP的目的。

Abstract:: The paper summarized bone metabolism related signaling pathways in diabetes osteoporosis (DOP) and the herbs of kidney-invigorating essence-replenishing for the prevention and treatment of DOP, the signaling pathways related to bone metabolism in DOP mainly contained Wnt/β-catenin, MAPK, NF-κB, Notch and OPG/RANKL/RANK, and the herbs of kidney-invigorating essence-replenishing for the prevention and treatment of DOP primarily covered Shudihuang(Rehmanniae radix praeparata), Lujiaojiao (Cervi cornus colla), Tusizi (Cuscutae semen) and Shanzhuyu (Corni fructus). The active ingredients of the herbs could maintain bone metabolism balance by regulating the signaling pathways such as Wnt/β-catenin, MAPK, NF-κB and others, thereby invigorating kidney and replenishing the essence, strengthening the tendon and bone, achieving the aims of treating DOP.