[1]王君,谭烨,杨如意,等.降红方对高原地区慢性阻塞性肺疾病稳定期患者生活质量的影响[J].西部中医药,2025,38(05):134-138.[doi:10.12174/j.issn.2096-9600.2025.05.25]
　WANG Jun,TAN Ye,YANG Ruyi,et al.Influence of RBC/Hemoglobin-lowering Prescription on Quality of Life of Stable COPD Patients in the High-altitude Area[J].Western Journal of Traditional Chinese Medicine,2025,38(05):134-138.[doi:10.12174/j.issn.2096-9600.2025.05.25]
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降红方对高原地区慢性阻塞性肺疾病稳定期患者生活质量的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年05期
页码:
134-138
栏目:
临床研究
出版日期:
2025-05-15

文章信息/Info

Title:
Influence of RBC/Hemoglobin-lowering Prescription on Quality of Life of Stable COPD Patients in the High-altitude Area
作者:
王君1, 谭烨2, 杨如意1, 李玉红1, 李晓平1, 曹昌霞1, 徐海珍1
1.青海大学附属医院，青海 西宁 810000
2.青海省中医院，青海 西宁 810000
Author(s):
WANG Jun1, TAN Ye2, YANG Ruyi1, LI Yuhong1, LI Xiaoping1, CAO Changxia1, XU Haizhen1
1.Affiliated Hospital of Qinghai University, Xining 810000, China
2.Qinghai Provincial Hospital of Traditional Chinese Medicine, Xining 810000, China
关键词:
慢性阻塞性肺疾病; 高原; 气虚血瘀证; 生活质量; 降红方
Keywords:
COPD; high-altitude area; deficiency and blood stasis pattern; quality of life; RBC/hemoglobin-lowering prescription
分类号:
R256.14
DOI:
10.12174/j.issn.2096-9600.2025.05.25
文献标志码:
B
摘要:
目的探讨降红方对高原地区慢性阻塞性肺疾病（chronic obstructive pulmonary disease，COPD）稳定期气虚血瘀证患者血气指标、肺功能、改良英国医学研究委员会呼吸问卷（modified medical research council dyspnea scale，mMRC）评分、COPD评估测试表（COPD assessment test，CAT）中医证候积分和临床疗效的影响。 方法选取60例长期生活在高原地区，被诊断为COPD稳定期并辨证为气虚血瘀证的患者，随机分为治疗组和对照组，每组30例。两组患者均给予布地格福吸入气雾剂常规西医治疗，治疗组同时口服降红方治疗，两组均治疗8周。比较两组患者治疗前后血气指标、肺功能、mMRC评分、CAT评分、中医证候积分、临床疗效和不良反应发生情况。 结果治疗后治疗组患者PaO2、SPO2、氧合指数较对照组上升（P＜0.05），PaCO2较对照组下降（P＜0.05）；治疗组患者肺功能FEV1%Pred水平高于对照组（P＜0.05）；治疗组患者mMRC分级分布改善更明显（P＜0.05）；治疗组患者CAT评分下降幅度大于对照组（P＜0.05）。治疗组患者各项中医证候积分减少及总积分减少优于对照组（P＜0.01）；治疗组临床总有效率［93.3%（28/30）］高于对照组［73.3%（22/30）］（P＜0.05）。 结论降红方能改善高原地区COPD稳定期气虚血瘀证患者血气指标，提高肺通气功能，提高患者生活质量，有效改善临床中医证候和临床疗效。
Abstract:
ObjectiveTo survey the influence of RBC/hemoglobin-lowering prescription on blood gas indicators, lung function, mMRC scores, CAT, TCM syndrome integrals and clinical effects of patients with stable COPD of Qi deficiency and blood stasis pattern in the high-altitude area. MethodsSixty patients living in the high-altitude areas for a long time, diagnosed as stable COPD and differentiated into Qi deficiency and blood stasis pattern, were randomized into the treatment group and the control group with 30 cases in each group. Both groups were treated with budesonide, glycopyrronium bromide and formoterol fumarate inhalation aerosol, and the treatment group orally took RBC/hemoglobin-lowering prescription, both groups were treated for eight weeks. To compare blood gas indicators, lung function, mMRC scores, CAT scales, TCM syndrome integrals, clinical effects and the incidence of adverse reaction before and after the treatment between the two groups. ResultsAfter the treatment, PaO2, SPO2 and oxygenation indexes of the treatment group were higher than these of the control group (P<0.05), PaCO2 was lower than the control group (P<0.05); the level of FEV1%Pred of the treatment group was higher than that of the control group (P<0.05); the improvements of mMRC grade were more significant in the treatment group (P<0.05); the decrease of CAT scores in the treatment group was greater than that of the control group (P<0.05). The decrease in TCM syndrome integrals and total scores in the treatment group was better than that in the control group (P<0.01); clinical total effective rate of the treatment group was [93.3%(28/30)], higher than [73.3%(22/30)] of the control group (P<0.05). ConclusionRBC/hemoglobin-lowering prescription could improve blood gas indicators, pulmonary ventilation function and the patients’ quality of life, effectively improve clinical TCM syndrome and clinical effects.

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备注/Memo

备注/Memo:
王君（1980—），男，硕士学位，副主任医师。研究方向：中西医结合呼吸系统疾病的研究。Email：527943518@qq.com。青海省自然科学基金（2019-ZJ-983Qy）；青海省中藏医药科研创新项目（J2022005）。
更新日期/Last Update: 2025-05-15