[1]贺艳,何峰.涤痰清脑汤联合无创正压通气对肺性脑病的影响[J].西部中医药,2025,38(05):143-146.[doi:10.12174/j.issn.2096-9600.2025.05.27]
　HE Yan,HE Feng.Effects of Ditan Qingnao Tang Combined with Noninvasive Positive Pressure Ventilation on Pulmonary Encephalopathy[J].Western Journal of Traditional Chinese Medicine,2025,38(05):143-146.[doi:10.12174/j.issn.2096-9600.2025.05.27]
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涤痰清脑汤联合无创正压通气对肺性脑病的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年05期
页码:
143-146
栏目:
衷中参西
出版日期:
2025-05-15

文章信息/Info

Title:
Effects of Ditan Qingnao Tang Combined with Noninvasive Positive Pressure Ventilation on Pulmonary Encephalopathy
作者:
贺艳1, 何峰2
1.恩施土家族苗族自治州中心医院，湖北 恩施 445000
2.湖北民族大学附属民大医院，湖北 恩施 445000
Author(s):
HE Yan1, HE Feng2
1.The Central Hospital of Enshi Tujia and Miao Autonomous Perfecture/Enshi Clinical College of Wuhan University, Enshi 445000, China
2.Minda Hospital Affiliated to Hubei Minzu University, Enshi 445000, China
关键词:
肺性脑病; 免疫; 中枢神经递质; 肺功能; 涤痰清脑汤; 无创正压通气
Keywords:
pulmonary encephalopathy; immunity; central neurotransmitter; pulmonary function; noninvasive positive pressure ventilation
分类号:
R256.24
DOI:
10.12174/j.issn.2096-9600.2025.05.27
文献标志码:
B
摘要:
目的探讨涤痰清脑汤联合无创正压通气（noninvasive positive pressure ventilation，NPPV）对肺性脑病患者免疫球蛋白G（IgG）、Th17/Treg细胞比值、神经元特异性烯醇化酶（neuron-specific enolase，NSE）、脑特异性蛋白（S100β）及肺功能的影响。 方法将肺性脑病患者150例，采用随机数字表法分为观察组72例和对照组78例。对照组采用NPPV治疗，观察组采用涤痰清脑汤联合NPPV治疗，均治疗2周。比较两组患者治疗前后免疫指标（血清IgG、外周血Th17细胞百分比、Treg细胞百分比、Th17/Treg比值）、中枢神经递质指标（血清NSE、S100β蛋白）、肺功能［第一秒用力呼气容积占用力肺活量的百分比（first second forced expiratory volume，FEV1%）、动脉血氧分压（arterial partial pressure of oxygen，PaO2）、动脉血二氧化碳分压（partial pressure of carbon dioxide in arterial，PaCO2）］、死亡率及不良反应率。 结果治疗后观察组患者血清IgG水平和Treg细胞百分比高于对照组（P＜0.05）；外周血Th17细胞百分比和Th17/Treg比值低于对照组（P＜0.05）。观察组患者血清NSE、S100β蛋白水平均低于对照组（P＜0.05）。观察组患者FEV1%、PaO2高于对照组（P＜0.05），PaCO2小于对照组（P＜0.05）。观察组患者病死率［8.33%（6/72）］低于对照组［20.51%（16/78］（P＜0.05）。不良反应率观察组为6.94%（5/72），对照组为5.13%（4/78），两组比较差异无统计学意义（P＞0.05）。 结论涤痰清脑汤联合NPPV可纠正肺性脑病患者呼吸衰竭，改善免疫力，调节中枢神经递质代谢，促进脑细胞恢复，提高肺功能。
Abstract:
ObjectiveTo discuss the impacts of Ditan Qingnao Tang (Sputum-cleansing Brain-clearing Decoction) joined with noninvasive positive pressure ventilation (NPPV) on the levels of IgG, Th17/Treg ratio, NSE, S100β and pulmonary function in patients with pulmonary encephalopathy. MethodsAll 150 patients were allocated to 72 cases of the observation group and 78 cases of the control group using random number table method. The control group adopted NPPV, and the observation group was treated by the decoction and NPPV, for two weeks. To compare the immunologic indexes including serum IgG, the percentage of Th17 cells, the percentage of Treg cells and Th17/Treg ratio in peripheral blood), central neurotransmitter (NSE, S100β protein in the serum), lung function (FEV1%, PaO2 and PaCO2), mortality rate and the rate of adverse reaction before and after the treatment between the two groups. ResultsAfter the treatment, the levels of serum IgG and the percentage of Treg cells of the observation group were higher than these of the control group (P<0.05); the percentage of Th17 cells and Th17/Treg ratio in peripheral blood was lower than that of the control group (P<0.05). The levels of serum NSE and S100β protein of the observation group were lower than these of the control group (P<0.05). The observation group was higher than the control group in FEV1% and PaO2 (P<0.05), lower than the control group in PaCO2 (P<0.05). Mortality rate of the observation group was [8.33%(6/72)], lower than [20.51%(16/78)] of the control group (P<0.05). The rate of adverse reaction of the observation group was [6.94%(5/72)], higher than [5.13%(4/78)] of the control group, and the difference had no statistical meaning (P>0.05). Conclusion Ditan Qingnao Tang and NPPV could correct respiratory failure, improve immunity, and regulate the metabolism of central neurotransmitter, promote the recovery of brain cells and lift lung function.

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备注/Memo

备注/Memo:
贺艳（1987—），女，主治医师。研究方向：呼吸康复。湖北省自然科学基金（2019FCB309）。
更新日期/Last Update: 2025-05-15