[1]米尔扎提·麦麦提,秦华夏,刘宇彤,等.大蒜素联合用药治疗复发性口腔溃疡临床疗效Meta分析[J].西部中医药,2025,38(06):90-95.[doi:10.12174/j.issn.2096-9600.2025.06.17]
　Mierzhati·MAIMAITI,QIN Huaxia,LIU Yutong,et al.Meta-analysis of Curative Effects of Combined Therapy with Allicin in the Treatment of Recurrent Aphthous Ulcer[J].Western Journal of Traditional Chinese Medicine,2025,38(06):90-95.[doi:10.12174/j.issn.2096-9600.2025.06.17]
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大蒜素联合用药治疗复发性口腔溃疡临床疗效Meta分析()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年06期
页码:
90-95
栏目:
二次研究
出版日期:
2025-06-15

文章信息/Info

Title:
Meta-analysis of Curative Effects of Combined Therapy with Allicin in the Treatment of Recurrent Aphthous Ulcer
作者:
米尔扎提·麦麦提1, 秦华夏1, 刘宇彤2, 张玉君1, 马璇1,3
1.新疆奇沐医药研究院，新疆 乌鲁木齐 830011
2.新奇康药业股份有限公司，新疆 乌鲁木齐 830011
3.新疆医科大学，新疆 乌鲁木齐 830011
Author(s):
Mierzhati·MAIMAITI 1, QIN Huaxia1, LIU Yutong2, ZHANG Yujun1, MA Xuan1,3
关键词:
复发性口腔溃疡; 大蒜素; 疼痛指标; Meta分析
Keywords:
recurrent oral ulcer; allicin; pain indexes; Meta analysis
分类号:
R276.8
DOI:
10.12174/j.issn.2096-9600.2025.06.17
文献标志码:
A
摘要:
目的系统评价大蒜素联合用药治疗复发性口腔溃疡（Recurrent aphthous ulcer，RAU）的有效性及安全性。 方法检索中文科技期刊数据库（Chinese Science and Technology Journal Database，CCD）、国家知识基础设施数据库（China National Knowledge Infrastructure，CNKI）、中国生物医学文献数据库（Chinese Biomedical Literature Database，CBMdisc）、中国学术期刊数据库（China Scholarly Periodical Database，CSPD）及PubMed数据库自建库至2021年9月收录的关于大蒜素联合用药治疗RAU的临床随机对照试验，根据纳入及排除标准筛选文献，使用RevMan 5.4.1和Stata 15.0软件进行Meta分析。 结果共纳入文献12篇，患者1259例。Meta分析结果显示：观察组总有效率（RR=1.12，95%CI：1.02～1.22，P=0.015）优于对照组；观察组CD3（MD=1.23，95%CI：0.72～1.73，P＜0.001）、CD4（MD=1.65，95%CI：0.76～2.53，P＜0.001）、CD4/CD8（MD=0.76，95%CI：0.33～1.19，P＜0.001）水平高于对照组，CD8（MD=-1.40，95%CI：-2.24～-0.05，P＜0.001）水平低于对照组；观察组疼痛指标0度水平（RR=2.01，95%CI：1.47～2.74，P＜0.001）高于对照组，I度水平（RR=0.71，95%CI：0.44～1.14，P=0.161）两组之间无统计学差异；疼痛指标Ⅱ度和Ⅲ度水平（RR=0.50，95%CI：0.28～0.89，P=0.019），（RR=0.19，95%CI：0.08～0.49，P=0.001）低于对照组；观察组TNF-α水平（MD＝-1.33，95%CI：-1.51～-1.14，P＜0.001）低于对照组；观察组溃疡愈合时间（MD＝-1.77，95%CI：-2.04～-1.51，P＜0.00001）短于对照组。 结论大蒜素联合用药治疗RAU的疗效优于单独用药或西药治疗，能有效改善RAU患者免疫功能、疼痛情况和体内炎症因子水平，缩短溃疡愈合时间。
Abstract:
ObjectiveTo systematically evaluate the effectiveness and safety of the combined therapy with allicin in the treatment of recurrent oral ulcer (RAU). MethodsClinical randomized controlled trials (RCTs) on the combined therapy with allicin in the treatment of RAU were searched from CCD, CNKI, and CBMdisc, CSPD, and PubMed databases between the time of establishing the databases and September, 2021, Meta analysis was performed using RevMan 5.4.1 and Stata 15.0 after the literature was screened according to the inclusion and exclusion criteria. ResultsThe study has included 12 papers, involving 1259 patients. Results of Meta analysis displayed that total effective rate (RR=1.12, 95%CI: 1.02-1.22, P=0.015) of the observation group was superior to that of the control group; the levels of CD3 (MD=1.23, 95%CI: 0.72-1.73, P<0.001), CD4 (MD=1.65, 95%CI: 0.76-2.53, P<0.001), and CD4/CD8 (MD=0.76, 95%CI: 0.33-1.19, P<0.001) of the observation group were higher than these of the control group, while the levels of CD8 (MD=-1.40, 95%CI: -2.24 - -0.05, P<0.001) of the observation group were lower than these of the control group; the levels of pain indexes at zero degree (RR=2.01, 95%CI: 1.47-2.74, P<0.001) of the observation group were higher than these of the control group, the difference had no statistical meaning in the levels of pain indexes at one degree (RR=0.71, 95%CI: 0.44-1.14, P=0.161); the levels of pain indexes at two (RR=0.50, 95%CI: 0.28-0.89, P=0.019) and three degrees (RR=0.19, 95%CI: 0.08-0.49, P=0.001) of the observation group were lower than these of the control group; the observation group was lower than the control group in the levels of TNF-α (MD=-1.33, 95%CI: -1.51 - -1.14, P<0.001), shorter than the control group in the healing time of ulcerations (MD=-1.77, 95%CI: -2.04 - -1.51, P<0.00001). ConclusionThe combined therapy with allicin in the treatment of RAU is better than single therapy or only Western medicine, it could effectively improve RAU patients’ immunity, pain conditions and the levels of inflammatory factor, and shorten the healing time of ulcerations.

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备注/Memo

备注/Memo:
米尔扎提·麦麦提（1989—），男，硕士学位，工程师。研究方向：药物分析与统计学。新疆维吾尔自治区重大科技专项（2021A03002-2）。
更新日期/Last Update: 2025-06-15