[1]马芳芳,程培育,杨永,等.“五行针灸”联合艾司唑仑治疗肿瘤相关性失眠疗效观察[J].西部中医药,2025,38(06):148-153.[doi:10.12174/j.issn.2096-9600.2025.06.30]
　MA Fangfang,CHENG Peiyu,YANG Yong,et al.Clinical Observation on "Five-element Needling" Joined with Estazolam in Treating Cancer-related Insomnia[J].Western Journal of Traditional Chinese Medicine,2025,38(06):148-153.[doi:10.12174/j.issn.2096-9600.2025.06.30]
点击复制

“五行针灸”联合艾司唑仑治疗肿瘤相关性失眠疗效观察()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年06期
页码:
148-153
栏目:
特色医疗
出版日期:
2025-06-15

文章信息/Info

Title:
Clinical Observation on "Five-element Needling" Joined with Estazolam in Treating Cancer-related Insomnia
作者:
马芳芳1, 程培育2, 杨永2, 李冰雪3, 于明薇2, 王笑民2
1.昆山市中医医院，江苏 苏州 215300
2.首都医科大学附属北京中医医院，北京 100010
3.上海交通大学附属瑞金医院，上海 200025
Author(s):
MA Fangfang1, CHENG Peiyu2, YANG Yong2, LI Bingxue3, YU Mingwei2, WANG Xiaomin2
关键词:
肿瘤; 失眠; 五行针灸; 艾司唑仑; 随机对照
Keywords:
cancer; insomnia; five-element needling; estazolam; randomized control
分类号:
R256.23
DOI:
10.12174/j.issn.2096-9600.2025.06.30
文献标志码:
B
摘要:
目的观察“五行针灸”联合艾司唑仑治疗肿瘤相关性失眠的临床疗效。 方法将76例肿瘤相关性失眠（cancer-related insomnia，CRI）患者随机分为观察组和对照组各38例。对照组予肿瘤常规治疗并口服艾司唑仑，观察组在对照组基础上予“五行针灸”治疗。比较两组患者临床疗效、匹兹堡睡眠质量指数（Pittsburgh sleep quality index，PSQI）量表评分、平均总睡眠时间和平均深睡眠时间、汉密尔顿抑郁量表（Hamilton depression scale，HAMD）及健康调查简表-36（the MOS item short from health survey，SF-36）量表评分。 结果观察组总有效率及愈显率均高于对照组（P＜0.05）；治疗后两组患者睡眠质量、入睡时间、睡眠时间、睡眠效率、睡眠障碍、催眠药物、日间功能障碍评分及PSQI总分均降低（P＜0.05），且观察组睡眠质量、睡眠时间、催眠药物、日间功能障碍评分及PSQI总分降低程度优于对照组（P＜0.05）。两组患者平均总睡眠时间、平均深睡眠时间均增加（P＜0.05），且观察组优于对照组（P＜0.05）；两组患者HAMD评分均降低（P＜0.05），且观察组低于对照组（P＜0.05）；两组患者SF-36生活质量各评分及总分均升高（P＜0.05），观察组生理功能、生理职能、活力、情感职能及总分升高程度优于对照组（P＜0.05）。 结论“五行针灸”联合艾司唑仑治疗肿瘤相关性失眠综合疗效疗效确切，能提高患者睡眠质量及生活质量。
Abstract:
ObjectiveTo investigate clinical effects of "five-element needling" and estazolam in treating cancer-related insomnia (CRI). MethodsAll 76 CRI patients were randomized into the observation group and the control group with 38 cases in each group. The control group accepted conventional therapy of cancer and oral administration of estazolam, and the observation group was treated with "five-element needling" based on the therapy of the control group. To compare clinical effects, the scores of PSQI scale, average total sleep time and average deep sleep time, HAMD and the scores of SF-36 scale between both groups. ResultsTotal effective rate, and the cure and markedly effective rates of the observation group were higher than these of the control group (P<0.05); after the treatment, the scores of sleep quality, time to fall asleep, sleep time, sleep efficiency, sleep disorder, and hypnotic drugs, daytime functional dysfunction scores and total scores of PSQI reduced in the two groups (P<0.05), and the observation group was better than the control group in the scores of sleep quality, sleep time, hypnotic drugs, daytime functional dysfunction scores and total scores of PSQI (P<0.05). Average total sleep time and average deep sleep time were increased in the two groups (P<0.05), and the observtion group was superior to the control group (P<0.05); HAMD scores were lowered in the two groups (P<0.05), and the observation group was lower than the control group (P<0.05); the scores of SF-36 and total scores were elevated in the two groups (P<0.05), and the observtion group was better than the control group in the increase of physical function, physiological role, vitality, emotional role and total scores (P<0.05). Conclusion"Five-element needling" and estazolam could gain definited clinical effects in the treatment of CRI, which could improve sleep quality and quality of life.

相似文献/References:

[1]李耀龙,代凤英,周启才,等.交藤龙牡二仁汤联合艾司唑仑治疗失眠30例[J].西部中医药,2011,24(11):34.
[2]张艳.论半夏安神治失眠[J].西部中医药,2012,25(11):43.
　ZHANG Yan.On Tranquilizing of BanXia for Insomnia[J].Western Journal of Traditional Chinese Medicine,2012,25(06):43.
[3]关亚珍,指导：张洪涛.“矩阵针法”治疗失眠的理论与临床应用研究[J].西部中医药,2013,26(10):70.
　GUAN Yazhen,DirectorZHANG Hongtao.Study on Clinical Application and Theory of “Matrix Acupuncture” in Treating Insomnia[J].Western Journal of Traditional Chinese Medicine,2013,26(06):70.
[4]徐伟,王守东△.耳穴埋籽加放松疗法对肿瘤患者睡眠质量障碍的影响[J].西部中医药,2014,27(03):115.
　XU Wei,Wang Shoudong.Effects of Ear Acupoint Pressing Method and Relax Therapy on Sleep Disorder of Cancer Patients[J].Western Journal of Traditional Chinese Medicine,2014,27(06):115.
[5]王秋兰,朱建坤,韩涛,等.白花蛇舌草总黄酮对苯并(a)芘致实体瘤小鼠IL-2和IL-6的影响[J].西部中医药,2015,28(05):14.
[6]吴玮,郑慧,王天宝.某中医院429名肿瘤住院患者构成分析[J].西部中医药,2015,28(07):90.
[7]杨德富,曹理璞.柴胡疏肝散加味治疗肝郁型失眠临床观察[J].西部中医药,2015,28(11):82.
[8]冯润,唐翠霞.骨科手术患者睡眠障碍的产生及防治对策[J].西部中医药,2011,24(11):24.
[9]王海升.养血清脑颗粒治疗顽固性失眠的临床观察[J].西部中医药,2012,25(10):81.
　WANG Hai-sheng.Clinical Observation on YangXue QingNao Granules in the Treatment for Intractable Insomnia[J].Western Journal of Traditional Chinese Medicine,2012,25(06):81.
[10]朱建坤,王秋兰△.白花蛇舌草抗肿瘤机制研究*[J].西部中医药,2013,26(06):119.
　ZHU Jiankun,WANG Qiulan.Research on Anti-tumor Mechanism of BaiHua SheSheCao[J].Western Journal of Traditional Chinese Medicine,2013,26(06):119.

备注/Memo

备注/Memo:
马芳芳（1986—），女，博士学位，主治医师。研究方向：针药结合防治肿瘤相关性疾病。北京市科技计划课题（Z191100008319006）；北京市博士后课题基金项目（EE2019-22）；苏州市基础研究计划项目-医学应用基础研究（SKYD2023016）；昆山市科技专项（KS2328）。
更新日期/Last Update: 2025-06-15