[1]夏迪,席俊羽,吕健,等.金天格胶囊在骨质疏松性骨折非手术疗法中的有效性和安全性系统评价[J].西部中医药,2025,38(10):55-61.[doi:10.12174/j.issn.2096-9600.2025.10.11]
　XIA Di,XI Junyu,LYU Jian,et al.Systematic Evaluation of the Effectiveness and Safety of Jintiange Capsules in Non-surgical Therapy for Osteoporotic Fracture[J].Western Journal of Traditional Chinese Medicine,2025,38(10):55-61.[doi:10.12174/j.issn.2096-9600.2025.10.11]
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金天格胶囊在骨质疏松性骨折非手术疗法中的有效性和安全性系统评价()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年10期
页码:
55-61
栏目:
二次研究
出版日期:
2025-10-15

文章信息/Info

Title:
Systematic Evaluation of the Effectiveness and Safety of Jintiange Capsules in Non-surgical Therapy for Osteoporotic Fracture
作者:
夏迪1, 席俊羽1, 吕健2, 谢雁鸣1
1.中国中医科学院中医临床基础医学研究所，北京 100700
2.中国中医科学院西苑医院，北京 100091
Author(s):
XIA Di1, XI Junyu1, LYU Jian2, XIE Yanming1
1.Institute of Basic Research In Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China
2.Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China
关键词:
骨质疏松性骨折; 金天格胶囊; 非手术治疗; 系统评价; Meta分析
Keywords:
osteoporotic fracture; capsules; non-surgical therapy; systematic evaluation; Meta analysis
分类号:
R274.9
DOI:
10.12174/j.issn.2096-9600.2025.10.11
文献标志码:
A
摘要:
目的系统评价金天格胶囊治疗骨质疏松性骨折（osteoporotic fracture，OF）的有效性和安全性。 方法计算机检索万方、维普、中国知网和Sinomed中文数据库以及Embase、Cochrane Library、Pubmed和Web of Science英文数据库中金天格胶囊治疗OF的临床随机对照试验；检索时间为自建库至2021年11月；由两名研究者独立检索并筛选文献、提取数据并评价纳入研究的偏倚风险；通过Cochrane系统评价手册评价其方法学依据，使用Revman 5.4软件进行Meta分析。 结果共纳入9项随机对照试验，Meta分析结果显示：金天格胶囊联合常规疗法治疗OF总有效率（RR=1.21，95%CI：1.10～1.34，P=0.000 1）优于常规疗法，且在降低视觉模拟量表（visual analogue scale，VAS）评分（MD=-1.14，95%CI：-1.30～-0.97，P＜0.000 01）、提高腰椎骨密度（MD=0.14，95%CI：0.09～0.19，P＜0.000 01）和股骨颈骨密度（MD=0.14，95%CI：0.08～0.19），P＜0.000 01）、缩短骨折愈合时间（MD=-17.49，95%CI：-20.76～-14.22，P＜0.000 01）方面优于常规疗法；在治疗骨质疏松性桡骨远端骨折时，有助于改善腕关节活动度（MD=5.32，95%CI：4.33～6.32，P＜0.000 01）。 结论与常规治疗相比，金天格胶囊联合常规治疗能够提高OF疗效，减轻疼痛、提升骨密度、促进骨折愈合，改善腕关节活动度，且无明显不良反应，安全性较高。
Abstract:
ObjectiveTo systematically assess the safety and effectiveness of Jintiange capsules in the treatment of osteoporotic fracture. MethodsClinical randomized controlled trials (RCTs) on Jintian?ge capsules for treating osteoporotic fracture were retrieved from Wanfang, VIP, and CNKI, Sinomed, Embase, Cochrane Library, Pubmed and Web of Science; the retrieval time was between the time of establishing the database and November, 2021; two researchers independently search and screen the literature, extract the data and assess the risk of bias in the included studies; the methodological quality was assessed using the Cochrane Handbook for Systematic Reviews of Interventions, and Meta analysis was conducted using Revman 5.4. ResultsThe study has included nine randomized controlled trials, the results of Meta analysis demonstrated that Jintian?ge capsules combined with conventional therapy was better than conventional therapy in total effective rate (RR=1.21, 95%CI:1.10-1.34, P=0.000 1), and decreasing VAS scores (MD=-1.14, 95%CI:-1.30--0.97, P<0.000 01), increasing lumbar bone density (MD=0.14, 95%CI:0.09-0.19, P<0.000 01) and bone density in femoral neck (MD=0.14, 95%CI:0.08-0.19, P<0.000 01), as well as shortening fracture healing time (MD=-17.49, 95%CI:-20.76--14.22, P<0.000 01); the combined therapy could help improve wrist joint mobility (MD=5.32, 95%CI:4.33-6.32, P<0.000 01) in treating osteoporotic distal radius fractures. ConclusionCompared with the conventional therapy, Jintian?ge capsules combined with conventional therapy could improve clinical effects of osteoporotic fracture, reduce pain, improve bone mineral density and promote fracture healing, and improve wrist joint mobility, presenting no obvious adverse reaction and high safety.

相似文献/References:

[1]丁杰,乔旭霞△.仙灵骨葆胶囊联合金天格胶囊治疗股骨干骨折骨质疏松症疗效观察[J].西部中医药,2019,32(01):74.
　DING Jie,QIAO Xuxia.Observation on XianLing GuBao Capsules Combined with JinTianGe Capsules in the Treatment for Femoral Shaft Fracture Accompanying Osteoporosis[J].Western Journal of Traditional Chinese Medicine,2019,32(10):74.

备注/Memo

备注/Memo:
夏迪（1998—），男，在读博士研究生。研究方向：中西医结合治疗脊柱及相关疾病。国家重点研发计划“中医药现代化研究”项目（2018YFC1707400）。
更新日期/Last Update: 2025-10-15