[1]范向荣,刘永辉,武洪杨,等.启膈散治疗食管癌的基础及临床研究进展[J].西部中医药,2025,38(11):97-101.[doi:10.12174/j.issn.2096-9600.2025.11.16]
　FAN Xiangrong,LIU Yonghui,WU Hongyang,et al.Basic and Clinical Research Progress of Qige Powder in the Treatment of Esophageal Cancer[J].Western Journal of Traditional Chinese Medicine,2025,38(11):97-101.[doi:10.12174/j.issn.2096-9600.2025.11.16]
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启膈散治疗食管癌的基础及临床研究进展()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年11期
页码:
97-101
栏目:
研究进展
出版日期:
2025-11-15

文章信息/Info

Title:
Basic and Clinical Research Progress of Qige Powder in the Treatment of Esophageal Cancer
作者:
范向荣1,2, 刘永辉1, 武洪杨1, 赵行1, 范焕芳3
1.河北中医药大学，河北 石家庄 050091
2.河北省第八人民医院，河北 石家庄 050011
3.河北中医药大学第一附属医院，河北 石家庄 050013
Author(s):
FAN Xiangrong1,2, LIU Yonghui1, WU Hongyang1, ZHAO Hang1, FAN Huanfang3
1.Hebei University of Chinese Medicine, Shijiazhuang 050091, China
2.The 8th People’s Hospital of Hebei Province, Shijiazhuang 050011, China
3.First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050013, China
关键词:
食管癌; 启膈散; 基础研究; 临床应用; 中医理论; 抗肿瘤机制; 研究进展
Keywords:
esophageal cancer; powder; basic research; clinical application; TCM theory; anti-tumor mechanism; research progress
分类号:
R27
DOI:
10.12174/j.issn.2096-9600.2025.11.16
文献标志码:
A
摘要:
从基础研究与临床研究两方面，系统综述启膈散治疗食管癌的研究进展，并梳理其治疗食管癌的中医理论基础。基础研究表明，启膈散可通过调控生长因子、细胞周期、细胞凋亡及微小RNA相关通路，抑制食管癌细胞增殖、侵袭与转移，同时增强肿瘤细胞对化疗的敏感性，并调节肿瘤微环境以发挥抗食管癌作用；临床研究证实，启膈散对化疗具有减毒增效的作用、能减轻食管癌术后并发症，可治疗食管癌放疗后的放射性食管炎。以上结果可为临床应用中医药治疗肿瘤和中药抗癌新药的研发提供借鉴。
Abstract:
We systematically reviewed the research progress of Qige powder in the treatment of esophageal cancer from basic research and clinical study, and collected TCM theoretical foundation for the powder in the treatment of esophageal cancer. Basic research indicated that the powder could restrain the proliferation, invasion and metastasis of esophageal cancer cells through regulating growth factor, cell cycle, cellular apoptosis and microRNA-associated pathways, meanwhile enhance the sensitivity of tumor cells to chemotherapy, and adjust tumor microenvironment so as to exert anti-tumor effects; clinical study confirmed that the powder has the effects of reducing the toxicity and enhancing clinical efficacy of chemotherapy, mitigating the complications after the operation of esophageal cancer, and treating radiation esophagitis after chemotherapy. The results could provide the reference for clinical application of herbs in treating tumors and the development of new anti-cancer drugs.

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备注/Memo

备注/Memo:
河北省自然科学基金（H2021423030）。范向荣（1996—），女，硕士学位，主治医师。研究方向：消化系统肿瘤的临床诊治。
更新日期/Last Update: 2025-11-15