[1]胡建国,刘桃丽,陈洪达,等.从血细胞角度探讨中医禁食疗法治疗2型糖尿病的安全性[J].西部中医药,2025,38(11):117-121.[doi:10.12174/j.issn.2096-9600.2025.11.20]
　HU Jianguo,LIU Taoli,CHEN Hongda,et al.Clinical Safety of TCM Fasting Therapy in Treating Type 2 Diabetes Mellitus from the Angle of Blood Cells[J].Western Journal of Traditional Chinese Medicine,2025,38(11):117-121.[doi:10.12174/j.issn.2096-9600.2025.11.20]
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从血细胞角度探讨中医禁食疗法治疗2型糖尿病的安全性()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年11期
页码:
117-121
栏目:
临床研究
出版日期:
2025-11-15

文章信息/Info

Title:
Clinical Safety of TCM Fasting Therapy in Treating Type 2 Diabetes Mellitus from the Angle of Blood Cells
作者:
胡建国, 刘桃丽, 陈洪达, 张耿鹏, 张丽, 张汀滢, 秦鉴
中山大学附属第七医院，广东 深圳 518107
Author(s):
HU Jianguo, LIU Taoli, CHEN Hongda, ZHANG Gengpeng, ZHANG Li, ZHANG Tingying, QIN Jian
The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China
关键词:
糖尿病; 2型; 中医禁食疗法; 血细胞; 安全性
Keywords:
diabetes mellitus;  type 2; TCM fasting therapy; blood cells; safety
分类号:
R259
DOI:
10.12174/j.issn.2096-9600.2025.11.20
文献标志码:
B
摘要:
目的从血细胞指标变化角度，回顾性分析中医禁食疗法治疗2型糖尿病（type 2 Diabetes Mellitus，T2DM）的临床安全性。 方法筛选接受9天中医禁食疗法（1天缓冲期+5天禁食期+3天恢复期）的10例T2DM患者，比较治疗前后患者的血细胞指标（含红细胞相关指标、白细胞相关指标、血小板相关指标）、空腹血糖、体质量及体质指数（body mass index，BMI）的变化情况。 结果治疗后，10例患者空腹血糖、体质量及BMI较治疗前下降（P＜0.05）；血小板总数（platelet count，PLT）、血小板压积（platelet hematocrit，PCT）较治疗前呈上升趋势，差异有统计学意义（P＜0.05）；血红蛋白（hemoglobin，Hb）、红细胞计数（red blood cell count，RBC）、红细胞比积（hematocrit，Hct）、平均红细胞体积（mean corpuscular volume，MCV）、平均红细胞血红蛋白含量（mean corpuscular hemoglobin，MCH）、平均红细胞血红蛋白浓度（mean corpuscular hemoglobin concentration，MCHC）、红细胞分布宽度（red blood cell volume distribution width，RDW）、红细胞分布宽度标准偏差（red blood cell volume distribution width standard deviation，RDW-SD）、白细胞总数（white blood cell count，WBC）、中性粒细胞绝对值（neutrophil count，NEUT#）、中性粒细胞百分比（neutrophil percent，NEUT%）、嗜酸细胞绝对值（eosinophil count，EO#）、嗜酸细胞百分比（eosinophil percent，EO%）、嗜碱细胞绝对值（basophil count，BASO#）、嗜碱细胞百分比（basophil percent，BASO%）、淋巴细胞绝对值（lymphocyte count，LY#）、淋巴细胞百分比（lymphocyte percent，LY%）、单核细胞绝对值（monocyte count，MO#）、单核细胞百分比（monocyte percent，MO%）、平均血小板体积（mean platelet volume，MPV）、血小板体积分布宽度（platelet volume distribution width，PDW）、大血小板百分率（platelet large cell ratio，P-LCR）等指标较治疗前无显著性改变（P＞0.05）。治疗期间仅1例患者出现轻度低血糖（空腹血糖3.3 mmol/L），经干预后血糖恢复正常，未出现明显不良反应。 结论中医禁食疗法在有效降低T2DM患者血糖、体质量的同时，对血细胞指标影响较小，总体临床安全性良好。
Abstract:
ObjectiveTo retrospectively analyze clinical safety of TCM fasting therapy in the treatment of type 2 diabetes mellitus (T2DM) from the angle of blood cells. MethodsWe screened ten T2DM patients who received nine-day TCM fasting therapy (one-day buffer period+five-day fasting period+three-day rehabilitation period), to compare the indexes of blood cells (covering blood cells related indexes, white blood cells and platelet-related indicators), fasting blood-glucose and body weight, body mass index (BMI) of the patients before and after the treatment. ResultsAfter the treatment, fasting blood-glucose, body weight and BMI in ten patients were lowered compared with before the treatment (P<0.05); PLT and PCT were on the upward trend than before the treatment, and the difference had statistical meaning (P<0.05); compared with before the treatment, Hb, RBC, and Hct, MCV, and MCH, MCHC, RDW and RDW-SD, WBC, NEUT#, NEUT%, and EO#, EO%, BASO# and BASO%, LY# and LY%, MO# and MO%, MPV, PDW, and P-LCR showed no significant changes (P>0.05). During therapeutic period, only one patients suffered mild hypoglycemia (FBG 3.3mmol/L), blood glucose returned to normal after intervention without obvious adverse reaction. ConclusionTCM fasting therapy could effectively lower blood glucose in T2DM patients and body weight, demonstrating less impacts on the indexes of blood cells, and good overall clinical safety.

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备注/Memo

备注/Memo:
国家自然科学基金（81874498）；广州市科技计划项目（201903010044）；深圳市自然科学基金（JCYJ20220530144606015）；深圳市卫生系统科研项目（SZLY2018002）。胡建国（1976—），男，博士学位，主任医师。研究方向：糖尿病的临床诊治。
更新日期/Last Update: 2025-11-15