[1]张波涛,任进平,王丽娜.黄芪生脉饮联合尼可地尔治疗气阴两虚型稳定型冠心病效果观察[J].西部中医药,2026,39(09):160-164.[doi:10.12174/j.issn.2096-9600.2026.09.31]
　ZHANG Botao,REN Jinping,WANG Lina.Observation on the Efficacy of Huangqi Shengmai Oral Liquid Combined with Nicorandil in the Treatment of Stable Coronary Heart Disease with Qi-Yin Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2026,39(09):160-164.[doi:10.12174/j.issn.2096-9600.2026.09.31]
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黄芪生脉饮联合尼可地尔治疗气阴两虚型稳定型冠心病效果观察()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年09期
页码:
160-164
栏目:
临床研究
出版日期:
2026-09-07

文章信息/Info

Title:
Observation on the Efficacy of Huangqi Shengmai Oral Liquid Combined with Nicorandil in the Treatment of Stable Coronary Heart Disease with Qi-Yin Deficiency Pattern
作者:
张波涛, 任进平, 王丽娜
北京怀柔医院，北京 101400
Author(s):
ZHANG Botao, REN Jinping, WANG Lina
Beijing Huairou Hospital, Beijing 101400, China
关键词:
稳定型冠心病; 气阴两虚; 黄芪生脉饮; 尼可地尔; 血流变; 炎性因子; 氧化应激
Keywords:
stable coronary heart disease; - Deficiency; oral liquid; Nicorandil; hemorheology;  inflammatory factors; oxidative stress
分类号:
R256.22
DOI:
10.12174/j.issn.2096-9600.2026.09.31
文献标志码:
B
摘要:
目的探讨黄芪生脉饮联合尼可地尔治疗气阴两虚型稳定型冠心病（coronary heart disease，CHD）的临床效果及对患者血流变、炎性因子和氧化应激因子的影响。 方法将188例气阴两虚型CHD患者采用随机数字表法分为对照组（94例，最终纳入统计92例）和观察组（94例，最终纳入统计93例）。对照组在常规治疗的基础上给予尼可地尔治疗，观察组在对照组基础上给予黄芪生脉饮治疗。比较两组患者中医症状积分、临床有效率、血流变指标、炎症指标［白细胞介素6（interleukin-6，IL-6）、肿瘤坏死因子α（tumor necrosis factor α，TNF-α）、细胞间黏附分子1（intercellular adhesion molecule-1，ICAM-1）］及氧化应激因子［总超氧化物歧化酶（total superoxide dismutase，T-SOD）、谷胱甘肽过氧化物酶（glutathione peroxidase，GSH-Px）、丙二醛（malondialdehyde，MDA）］表达水平。 结果治疗后两组患者中医症状评分、全血高切黏度、全血低切黏度、血浆黏度、纤维蛋白、IL-6、TNF-α、ICAM-1、MDA水平均较治疗前降低（P＜0.05），观察组低于对照组（P＜0.05）。治疗后两组患者T-SOD、GSH-Px水平均高于治疗前（P＜0.05），观察组高于对照组（P＜0.05）。观察组临床有效率高于对照组（P＜0.05）。 结论黄芪生脉饮联合尼可地尔可降低稳定型CHD患者炎症因子水平，减轻氧化应激，改善血流变，减少中医症状积分，提高临床有效率。
Abstract:
ObjectiveTo investigate the clinical efficacy of Huangqi Shengmai oral liquid combined with Nicorandil in the treatment of stable coronary heart disease (CHD) with Qi-Yin Deficiency pattern, and to evaluate its effects on hemorheology, inflammatory factors, and oxidative stress factors in patients. MethodsA total of 188 patients with stable CHD of Qi-Yin Deficiency pattern were randomly divided into a control group (94 cases, with 92 cases finally included in the statistical analysis) and an observation group (94 cases, with 93 cases finally included in the statistical analysis) using a random number table method. The control group received Nicorandil on the basis of conventional treatment, while the observation group received Huangqi Shengmai oral liquid in addition to the treatment of the control group. The two groups were compared in terms of traditional Chinese medicine (TCM) symptom scores, clinical efficacy rates, hemorheological parameters, inflammatory markers [interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and intercellular adhesion molecule-1 (ICAM-1)], and oxidative stress markers [total superoxide dismutase (T-SOD), glutathione peroxidase (GSH-Px), and malondial-dehyde (MDA)] expression levels. ResultsAfter treatment, the levels of TCM symptom scores, whole-blood high-shear viscosity, whole-blood low-shear viscosity, plasma viscosity, fibrinogen, IL-6, TNF-α, ICAM-1, and MDA in both groups were significantly decreased compared with those before treatment (P<0.05), and the levels in the observation group were lower than those in the control group (P<0.05). The levels of T-SOD and GSH-Px in both groups were significantly increased after treatment compared with those before treatment (P<0.05), and the levels in the observation group were higher than those in the control group (P<0.05). The clinical efficacy rate in the observation group was higher than that in the control group (P<0.05). ConclusionThe combination of Huangqi Shengmai oral liquid and Nicorandil can reduce the levels of inflammatory cytokines, alleviate oxidative stress, improve hemorheological parameters, decrease TCM symptom scores, and enhance the clinical efficacy rate in patients with stable CHD.

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备注/Memo

备注/Memo:
北京中医药新时代125工程项目（京中医科字〔2025〕2号）。张波涛（1983—），男，硕士学位，副主任医师。研究方向：冠脉介入、冠心病、高血压、心律失常的中西医结合治疗。Email：tao5563742@163.com。
更新日期/Last Update: 2026-09-15