[1]赵道洲,郑恒恒△,李兴国.通络搽剂治疗软组织损伤的主要药效学研究*[J].西部中医药,2012,25(09):8-11.
　ZHAO Dao-zhou,ZHENG Heng-heng,LI Xing-guo.Pharmacodynamics of TongLuo ChaJi in Treating Soft Tissue Injury[J].Western Journal of Traditional Chinese Medicine,2012,25(09):8-11.
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通络搽剂治疗软组织损伤的主要药效学研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年09期
页码:
8-11
栏目:
出版日期:
2012-09-15

文章信息/Info

Title:
Pharmacodynamics of TongLuo ChaJi in Treating Soft Tissue Injury
文章编号:
1004-6852(2012)09-0008-04
作者:
赵道洲1，郑恒恒2△，李兴国2
1 甘肃省中医院，甘肃 兰州 730050； 2 甘肃中医学院
Author(s):
ZHAO Dao-zhou1, ZHENG Heng-heng2△, LI Xing-guo2
1 Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Gansu University of Traditional Chinese Medicine
关键词:
软组织损伤; 中药; 通络搽剂; 药效学
Keywords:
soft tissue injury;  Chinese herb;  TongLuo ChaJi;  pharmacodynamics
分类号:
R274.3
文献标志码:
A
摘要:
目的：通过建立动物损伤模型，采用通络搽剂作为治疗药物，从分子生物学、组织形态学、病理学角度研究通络搽剂对大鼠软组织损伤的修复作用，为该药临床治疗急性软组织损伤提供理论依据。方法：取50只健康、成年清洁级大鼠，随机分为3组，造模后按第1天、第3天、第5天3个时相，每组随机取5只大鼠，采集血液和损伤软组织，观察相关药物的药理作用。结果：白介素1(IL-1)和前列腺素PGE2浓度在第2到第3次测量时相点模型对照组与通络搽剂组比较差异显著(P＜0.05)；经过中药通络搽剂5天治疗后局部损伤软组织基本接近于正常组织；通络搽剂组和正骨水组均能促进损伤局部肿胀、皮下瘀斑和皮下出血的消散，与模型对照组相比有明显的差异(P＜0.05)。结论：中药通络搽剂对实验大鼠软组织损伤有明显的修复作用。
Abstract:
Objective: To verify the efficacy of TongLuo ChaJi in treating soft tissue injury from molecular biology, histomorphology and pathology by treating animal models with TongLuo ChaJi in order to provide theoretical evidence for clinical application. Method: All 50 rats were assigned randomly into three groups. Five rats were chosen from each group to collect blood and injured soft tissue. Pharmacological actions of associated drugs were observed on three time phases at the first day, third day and fifth day after successfully establishing the models. Result: Comparison between model group and TongLuo ChaJi group showed remarkable difference in concentrations of interleukin (IL-1) and prostaglandin (PGE2) at the second to the third survey (P＜0.05); local injured soft tissue nearly restored to normal tissue; TongLuo ChaJi and ZhengGuShui could promote the elimination of local swelling, ecchymosis and bruising, both groups indicated remarkable difference compared with model control group(P＜0.05). Conclusion: TongLuo ChaJi suggested notable rehabilitation for experimental rat with soft tissue injury.

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备注/Memo

备注/Memo:
收稿日期：2012-04-27 *基金项目：国家科技部技术创新基金项目(编号10C262162-05297) 作者简介：赵道洲(1962—)，男，硕士研究生导师，主任医师。研究方向：脊柱疾病的临床与理论研究。 △通讯作者：郑恒恒(1979—)，男，硕士研究生。研究方向：中医骨伤科外用药与外固定器械的研究。
更新日期/Last Update: 2012-09-15