[1]邴雅珺.通脑丸干预脑动脉硬化症慢性脑缺血损伤的作用机制研究*[J].西部中医药,2013,26(06):6-9.
　BING Yajun.Study on the Mechanism of TongNaoW an Intervening the Injury of Chronic Cerebral Ischemia Induced by Cerebral Arteriosclerosis[J].Western Journal of Traditional Chinese Medicine,2013,26(06):6-9.
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通脑丸干预脑动脉硬化症慢性脑缺血损伤的作用机制研究*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年06期
页码:
6-9
栏目:
出版日期:
2013-06-15

文章信息/Info

Title:
Study on the Mechanism of TongNaoW an Intervening the Injury of Chronic Cerebral Ischemia Induced by Cerebral Arteriosclerosis
文章编号:
1004-6852(2013)06-0006-04
作者:
邴雅珺
甘肃省中医院老年病科，甘肃 兰州 730050
Author(s):
BING Yajun
Geriatrics of Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
脑动脉硬化症; 通脑丸; 步长脑心通胶囊; 脑组织; 神经保护
Keywords:
cerebral arteriosclerosis;  TongNaoWan;  BuChang NaoXinTong capsule;  cerebral tissue; neural protection
分类号:
R285.5
文献标志码:
A
摘要:
目的：探讨通脑丸干预脑动脉硬化症慢性脑缺血损伤的作用机制。方法：以双肾双夹法复制肾性高血压进而建立脑动脉硬化症模型大鼠为研究对象，持续灌胃 14 周后，观察各组大鼠血脂、血清学相关指 标、脑组织血管内皮生长因子(VEGF)含量的变化。结果：治疗第 14 周末时，与模型组比较，步长脑心通组，通脑丸高、低剂量组总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)水平、血清丙二醛(MDA)含量均有显著降低，高密度脂蛋白胆固醇(HDL-C)、血清超氧化物歧化酶(SOD)含量、谷胱甘肽过氧化物酶(GSH-PX)活性、VEGF 的表达显著升高(P＜0.05)。与步长脑心通组比较，通脑丸高、低剂量组的 TC、TG、LDL-C 三项血脂指标降低显著，HDL-C、VEGF 的表达显著升高；通脑丸高、低剂量组 SOD 含量、MDA 含量、GSH-PX 活性无统计学意义(P＞0.05)。通脑丸高剂量组 TC、TG、LDL-C、VEGF 优于低剂量组，差异有显著性意义(P＜0.05)。结论：通脑丸可通过提高 SOD、GSH-PX 活性活力，上调脑动脉硬化症模型大鼠脑组织 VEGF 表达，降低 MDA 的含量，从而减轻动脉粥样硬化发展过程中的自由基损伤，发挥抗脑细胞损伤的作用，其效应与步长脑心通相似。
Abstract:
Objective: To explore the mechanism of TongNaoWan intervening the injury of chronic cerebral ischemia induced by cerebral arteriosclerosis. Method: Rat models were established through two-kidney two-clip method replicating renal hypertension. Changes of the related indexes of blood fat, serology and the content of VEGF in cerebral tissue of rats were observed in different groups after lavage for 14 consecutive weeks. Result: By the end of 14th week, compared with model group, the contents of TC, TG, LDL-C and MDA in the groups of BuChang NaoXinTong, high and low dosage of TongNaoW an were decreased signficantly, the contents of HDL-C and SOD, the activity of GSH-PX and the expression of VEGF were remarkably improved (P＜ 0.05). Compared with BuChang NaoXinTong group, the decrease of TC, TG and LDL-C was greater in the high and low dosage groups of TongNaoWan, the expressions of HDL-C and VEGF were raised significantly; it showed no statistical meaning in the contents of SOD, MDA and the activity of GSH-PX of the high and low dosage groups of TongNaoWan (P＞ 0.05). The contents of TC, TG, LDL-C and VEGF in the high dose group of TongNaoW an were superior to low dosage group among the groups of TongNaoWan, the difference was significant (P＜ 0.05). Conclusion:TongNaoW an could raise the activity of SOD and GSH-PX, improve the expression of VEGF in cerebral tissue of rat with cerebral arteriosclerosis and lower the content of MDA, therefore to relieve the damage of free radical during the development of cerebral arteriosclerosis and play the role of anti-injury cerebral cells, the function is similar to BuChang NaoXinTong.

相似文献/References:

[1]脱承德,李建省△,刘野,等.通脑丸对慢性脑缺血性大鼠血清GSH—Px、MDA含量的影响[J].西部中医药,2012,25(08):23.
　TUO Cheng-de,LI Jian-sheng,LIU Ye,et al.Effect of TongNaoWan on Contents of GSH-Px and MDA in Serum of Rat with Chronic Cerebral Ischemia[J].Western Journal of Traditional Chinese Medicine,2012,25(06):23.

备注/Memo

备注/Memo:
收稿日期：2012-12-04 * 基金项目：甘肃省科技厅科技支撑计划重点项目(编号0804NKCA089) 作者简介：邴雅珺(1965—)，女，主任医师，硕士研究生导师，甘肃省卫生厅领军人才，甘肃省中医院老年病科学科带头人；兼任甘肃省中医药学会老年病专业委员会副主任委员兼秘书长、甘肃省中医药学会理事、甘肃省中西医结合学会糖尿病专业委员会主任委员、甘肃省中西医结合学会络病委员会副主任委员、中国中西医结合学会虚证与老年病专业委员会青年委员、中国北方老年医学协会理事。研究方向：老年常见疾病的中西医防治。
更新日期/Last Update: 2013-06-15