[1]杨华,曾娟花.血清TNF与2型糖尿病肾病及其中医证型关系的临床研究[J].西部中医药,2014,27(01):11-13.
　YANG Hua,ZENG Juanhua.Clinical Study on the Relationship between Serum TNF and Type 2 Diabetic Nephropathy[J].Western Journal of Traditional Chinese Medicine,2014,27(01):11-13.
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血清TNF与2型糖尿病肾病及其中医证型关系的临床研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年01期
页码:
11-13
栏目:
出版日期:
2014-01-14

文章信息/Info

Title:
Clinical Study on the Relationship between Serum TNF and Type 2 Diabetic Nephropathy
文章编号:
1004-6852(2014)01-0011-03
作者:
杨华，曾娟花
上海中医药大学附属龙华医院内分泌科，上海 200032
Author(s):
YANG Hua, ZENG Juanhua
Department of Endocrinology in Longhua Hospital Shanghai University of TCM, Shanghai 200032, China
关键词:
糖尿病肾病; TNF; 血瘀证; 痰湿证
Keywords:
diabetic nephropathy;  TNF;  blood stasis pattern;  phlegm-dampness pattern
分类号:
R259
文献标志码:
A
摘要:
目的：分析血清TNF水平与2型糖尿病肾病(DN)的关系，并探讨TNF与血瘀证、痰湿证的相关性。方法：检测入选170例DN Ⅲ、Ⅳ及Ⅴ期患者的尿微量白蛋白(UAlb)及血清肌酐等指标，并采用MDRD计算公式计算血瘀证、痰湿证、血瘀兼痰湿证、无血瘀痰湿证患者的肾小球滤过率（GFR），比较各组TNF值变化情况。结果：①血清TNF随DN病情的加重而逐渐升高，Ⅴ期TNF高于Ⅲ期、Ⅳ期(P＜0.01，P＜0.05)，Ⅳ期高于Ⅲ期(P＜0.01)。②血清TNF与UAlb呈正相关(r=0.272，P=0.000)，与GRF呈负相关(r=-0.455，P=0.000)。③随着血瘀证、痰湿证的发生，TNF逐渐升高，血瘀兼痰湿证组最高。结论：血清TNF可能参与了DN的发生发展，与其肾脏损害程度一致；中医的痰湿、血瘀与TNF有关。
Abstract:
Objective: To analyze the relationship between the level of serum TNF and type 2 diabetic nephropathy(DN), meanwhile, to explore the relativity between TNF and blood stasis pattern, phlegm-dampness pattern. Methods: The indexes of 170 patients at Ⅲ, Ⅳ and Ⅴ stages including UAlb, serum creatinine and others were tested, glomerular filtration rates(GFR) of the patients with blood stasis pattern, phlegm-dampness pattern, blood stasis and phlegm-dampness pattern, without blood stasis and phlegm-dampness pattern were calculated with MDRD formula and the changes of TNF values in different groups were compared. Results: ① Serum TNF increased as DN aggravated, the value at Ⅴ stage was higher than those at Ⅲ and Ⅳ stages (P＜0.01, P＜0.05); TNF at Ⅳ stage was higher than that at Ⅲ stage (P＜0.01). ② Serum TNF was closely related to UAlb (r=0.272, P=0.000); it was negatively related to GRF (r=-0.455, P=0.000). ③TNF increased gradually as blood stasis pattern and phlegm-dampness pattern occurred, and the index in the group of blood stasis and phlegm-dampness was the highest. Conclusion: Serum TNF might be relevant to the development of DN, identical with the degree of renal impairment; phlegm-dampness and blood stasis are associated with TNF.

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备注/Memo

备注/Memo:
收稿日期：2013-03-27作者简介：杨华(1969—)，女，副主任医师。研究方向：糖尿病肾病的中西医结合诊治。
更新日期/Last Update: 2014-01-15